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Present and future ...
Present and future challenges for the investigation of transgenerational epigenetic inheritance
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- Fallet, Manon, 1992- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Biochemistry, Dorothy Crowfoot Hodgkin Building, University of Oxford, South Parks Rd, Oxford OX1 3QU, United Kingdom,Man-Technology-Environment Research Centre (MTM),Örebro Univ, Man Technol Environm Res Ctr MTM, Sch Sci & Technol, Fakultetsgatan 1, S-70182 Örebro, Sweden.;Univ Oxford, Dept Biochem, Dorothy Crowfoot Hodgkin Bldg,South Parks Rd, Oxford OX1 3QU, England.
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- Blanc, Mélanie (författare)
- Univ Montpellier, MARBEC, CNRS, Ifremer,IRD,INRAE, Palavas Les Flots, France.
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- Di Criscio, Michela (författare)
- Uppsala universitet,Fysiologi och miljötoxikologi,Department of Organismal Biology, Uppsala University, Norbyv. 18A, 75236 Uppsala, Sweden
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- Antczak, Philipp (författare)
- Univ Cologne, Fac Med, Cologne, Germany.;Cologne Univ Hosp, Ctr Mol Med Cologne, Cologne, Germany.;Univ Cologne, Excellence Cluster Cellular Stress Responses Aging, Cologne, Germany.,University of Cologne, Faculty of Medicine and Cologne University Hospital, Center for Molecular Medicine Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases, University of Cologne, Cologne, Germany
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- Engwall, Magnus, 1965- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Centre (MTM),Örebro Univ, Man Technol Environm Res Ctr MTM, Sch Sci & Technol, Fakultetsgatan 1, S-70182 Örebro, Sweden.
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- Guerrero-Bosagna, Carlos, 1975- (författare)
- Uppsala universitet,Fysiologi och miljötoxikologi,Department of Organismal Biology, Uppsala University, Norbyv. 18A, 75236 Uppsala, Sweden
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- Rüegg, Joëlle (författare)
- Uppsala universitet,Fysiologi och miljötoxikologi,Department of Organismal Biology, Uppsala University, Norbyv. 18A, 75236 Uppsala, Sweden
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- Keiter, Steffen, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Centre (MTM),Örebro Univ, Man Technol Environm Res Ctr MTM, Sch Sci & Technol, Fakultetsgatan 1, S-70182 Örebro, Sweden.
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 172
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Epigenetic pathways are essential in different biological processes and in phenotype-environment interactions in response to different stressors and they can induce phenotypic plasticity. They encompass several processes that are mitotically and, in some cases, meiotically heritable, so they can be transferred to subsequent generations via the germline. Transgenerational Epigenetic Inheritance (TEI) describes the phenomenon that phenotypic traits, such as changes in fertility, metabolic function, or behavior, induced by environmental factors (e.g., parental care, pathogens, pollutants, climate change), can be transferred to offspring generations via epigenetic mecha-nisms. Investigations on TEI contribute to deciphering the role of epigenetic mechanisms in adaptation, adver-sity, and evolution. However, molecular mechanisms underlying the transmission of epigenetic changes between generations, and the downstream chain of events leading to persistent phenotypic changes, remain unclear. Therefore, inter-, (transmission of information between parental and offspring generation via direct exposure) and transgenerational (transmission of information through several generations with disappearance of the triggering factor) consequences of epigenetic modifications remain major issues in the field of modern biology.In this article, we review and describe the major gaps and issues still encountered in the TEI field: the general challenges faced in epigenetic research; deciphering the key epigenetic mechanisms in inheritance processes; identifying the relevant drivers for TEI and implement a collaborative and multi-disciplinary approach to study TEI. Finally, we provide suggestions on how to overcome these challenges and ultimately be able to identify the specific contribution of epigenetics in transgenerational inheritance and use the correct tools for environmental science investigation and biomarkers identification.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Nyckelord
- Evolution
- DNA methylation
- Post-translational histone modifications
- Non-coding RNAs
- Phenotypic plasticity
- Adaptation
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Fallet, Manon, 1 ...
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Blanc, Mélanie
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Di Criscio, Mich ...
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Antczak, Philipp
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Engwall, Magnus, ...
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Guerrero-Bosagna ...
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Rüegg, Joëlle
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Keiter, Steffen, ...
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Environment Inte ...
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Uppsala universitet
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