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  • Baldanzi, GabrielUppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab (author)

OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Elsevier,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-498595
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-498595URI
  • https://doi.org/10.1016/j.chest.2023.03.010DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:du-45692URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154241169URI
  • https://lup.lub.lu.se/record/a13068b8-cb2b-4789-808b-e6d647b6ca0fURI
  • https://gup.ub.gu.se/publication/324656URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Obstructive sleep apnea (OSA) is a common sleep-breathing disorder linked to increased risk of cardiovascular disease. Intermittent hypoxia and intermittent airway obstruction, hallmarks of OSA, have been shown in animal models to induce substantial changes to the gut microbiota composition and subsequent transplantation of fecal matter to other animals induced changes in blood pressure and glucose metabolism.RESEARCH QUESTION: Does obstructive sleep apnea in adults associate with the composition and metabolic potential of the human gut microbiota?STUDY DESIGN AND METHODS: We used respiratory polygraphy data from up to 3,570 individuals aged 50-64 from the population-based Swedish CardioPulmonary bioImage Study combined with deep shotgun metagenomics of fecal samples to identify cross-sectional associations between three OSA parameters covering apneas and hypopneas, cumulative sleep time in hypoxia and number of oxygen desaturation events with gut microbiota composition. Data collection about potential confounders was based on questionnaires, on-site anthropometric measurements, plasma metabolomics, and linkage with the Swedish Prescribed Drug Register.RESULTS: We found that all three OSA parameters were associated with lower diversity of species in the gut. Further, the OSA-related hypoxia parameters were in multivariable-adjusted analysis associated with the relative abundance of 128 gut bacterial species, including higher abundance of Blautia obeum and Collinsela aerofaciens. The latter species was also independently associated with increased systolic blood pressure. Further, the cumulative time in hypoxia during sleep was associated with the abundance of genes involved in nine gut microbiota metabolic pathways, including propionate production from lactate. Lastly, we observed two heterogeneous sets of plasma metabolites with opposite association with species positively and negatively associated with hypoxia parameters, respectively.INTERPRETATION: OSA-related hypoxia, but not the number of apneas/hypopneas, is associated with specific gut microbiota species and functions. Our findings lay the foundation for future research on the gut microbiota-mediated health effects of OSA.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sayols-Baixeras, SergiUppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,CIBER Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain,Carlos III Health Institute(Swepub:uu)sersa467 (author)
  • Theorell-Haglöw, JennyUppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Lung- allergi- och sömnforskning(Swepub:uu)jethe020 (author)
  • Dekkers, Koen F.Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)koede543 (author)
  • Hammar, UlfUppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ulfha881 (author)
  • Nguyen, Diem,PhDUppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi(Swepub:uu)dieng296 (author)
  • Lin, Yi-Ting,1981-Uppsala University,Karolinska Institute,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Division of Family Medicine and Primary Care, Department of Neurobiology, Care Science and Society, Karolinska Institute, Huddinge, Sweden; Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan,Kaohsiung Medical University Chung-Ho Memorial Hospital(Swepub:uu)yitli615 (author)
  • Ahmad, ShafqatUppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Preventive Medicine Division, Harvard Medical School, Brigham and Women’s Hospital, Boston, MA(Swepub:uu)shaah996 (author)
  • Bak Holm, JacobClinical Microbiomics (author)
  • Nielsen, Henrik BjørnClinical Microbiomics (author)
  • Brunkwall, LouiseLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-lbw (author)
  • Benedict, Christian,Docent,1976-Uppsala University,Uppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)chrbe136 (author)
  • Cedernaes, Jonathan,Docent,1985-Uppsala University,Uppsala universitet,Transplantation och regenerativ medicin,Institutionen för medicinsk cellbiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)jonce840 (author)
  • Koskiniemi, Sanna,1980-Uppsala University,Uppsala universitet,Mikrobiologi och immunologi(Swepub:uu)sakos168 (author)
  • Phillipson, Mia,1973-Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Integrativ Fysiologi(Swepub:uu)mjo07958 (author)
  • Lind, LarsUppsala University,Uppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind (author)
  • Sundström, Johan,Professor,1971-Uppsala University,Uppsala universitet,Klinisk epidemiologi,The George Institute for Global Health, University of New South Wales, Sydney, NSW, Australia(Swepub:uu)johasund (author)
  • Bergström, Göran,1964Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xbgort (author)
  • Engström, GunnarLund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups(Swepub:lu)smi-gen (author)
  • Smith, J. GustavGothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Heart Failure and Mechanical Support,Forskargrupper vid Lunds universitet,Molecular Epidemiology and Cardiology,Cardiovascular Epigenetics,WCMM- Wallenberg center för molekylär medicinsk forskning,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xsmigu (author)
  • Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor (author)
  • Ärnlöv, Johan,1970-Karolinska Institute,Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet, Huddinge(Swepub:du)jan (author)
  • Kennedy, Beatrice,1982-Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)beake215 (author)
  • Lindberg, EvaUppsala University,Uppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)evalb (author)
  • Fall, Tove,1979-Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi(Swepub:uu)tovfa878 (author)
  • Uppsala universitetMolekylär epidemiologi (creator_code:org_t)

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  • In:Chest: Elsevier164:2, s. 503-5160012-36921931-3543

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