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Ghrelin proteolysis increases in plasma of men, but not women, with obesity

Fittipaldi, Antonela S. (författare)
Univ Nacl La Plata UNLP, Consejo Nacl Invest Cient & Tecn CONICET, Grp Neurofisiol, Inst Multidisciplinario Biol Celular IMBICE, La Plata, Argentina.;Comis Invest Cient Prov Buenos Aires CIC PBA, La Plata, Argentina.
Castrogiovanni, Daniel (författare)
Univ Nacl La Plata UNLP, Consejo Nacl Invest Cient & Tecn CONICET, Grp Neurofisiol, Inst Multidisciplinario Biol Celular IMBICE, La Plata, Argentina.;Comis Invest Cient Prov Buenos Aires CIC PBA, La Plata, Argentina.
Lufrano, Daniela (författare)
Univ Nacl La Plata UNLP, Consejo Nacl Invest Cient & Tecn CONICET, Grp Neurofisiol, Inst Multidisciplinario Biol Celular IMBICE, La Plata, Argentina.;Comis Invest Cient Prov Buenos Aires CIC PBA, La Plata, Argentina.
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Saenz, Camila (författare)
Univ Nacl La Plata UNLP, Consejo Nacl Invest Cient & Tecn CONICET, Grp Neurofisiol, Inst Multidisciplinario Biol Celular IMBICE, La Plata, Argentina.;Comis Invest Cient Prov Buenos Aires CIC PBA, La Plata, Argentina.
De Francesco, Pablo N. (författare)
Univ Nacl La Plata UNLP, Consejo Nacl Invest Cient & Tecn CONICET, Grp Neurofisiol, Inst Multidisciplinario Biol Celular IMBICE, La Plata, Argentina.;Comis Invest Cient Prov Buenos Aires CIC PBA, La Plata, Argentina.
Lalonde, Tyler (författare)
Univ Western Ontario, Dept Chem, London, ON, Canada.
Luyt, Leonard G. (författare)
Univ Western Ontario, Dept Chem, London, ON, Canada.
Cantel, Sonia (författare)
Univ Montpellier, Inst Biomol Max Mousseron IBMM, CNRS, ENSCM, Montpellier, France.
Fehrentz, Jean -Alain (författare)
Univ Montpellier, Inst Biomol Max Mousseron IBMM, CNRS, ENSCM, Montpellier, France.
Andreoli, Maria F. (författare)
CIC PBA, Inst Desarrollo Invest Pediat IDIP, HIAEP Sor Maria Ludovica La Plata, La Plata, Argentina.;Consejo Nacl Invest Cient & Tecn CONICET, La Plata, Argentina.
Perello, Mario (författare)
Uppsala universitet,Funktionell farmakologi och neurovetenskap,Univ Nacl La Plata UNLP, Consejo Nacl Invest Cient & Tecn CONICET, Grp Neurofisiol, Inst Multidisciplinario Biol Celular IMBICE, La Plata, Argentina.;Comis Invest Cient Prov Buenos Aires CIC PBA, La Plata, Argentina.
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Univ Nacl La Plata UNLP, Consejo Nacl Invest Cient & Tecn CONICET, Grp Neurofisiol, Inst Multidisciplinario Biol Celular IMBICE, La Plata, Argentina;Comis Invest Cient Prov Buenos Aires CIC PBA, La Plata, Argentina. Univ Western Ontario, Dept Chem, London, ON, Canada. (creator_code:org_t)
Elsevier, 2023
2023
Engelska.
Ingår i: Life Sciences. - : Elsevier. - 0024-3205 .- 1879-0631. ; 313
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Aims: Since plasma ghrelin can undergo des-acylation and proteolysis, the aim of this study was to investigate the extent to which an enhancement of these reactions is associated to the decrease of ghrelin in plasma after food intake or in individuals with obesity.Main methods: we performed an intervention cross-sectional study, in which levels of ghrelin, desacyl-ghrelin (DAG), glucose, insulin, ghrelin des-acylation and ghrelin proteolysis were assessed in plasma before and after a test meal in 40 people (n = 21 males) with normal weight (NW, n = 20) or overweight/obesity (OW/OB, n = 20).Key findings: Preprandial ghrelin and DAG levels were lower, whereas preprandial ghrelin proteolysis was -4.6-fold higher in plasma of males with OW/OB. In males, ghrelin proteolysis positively correlated with glycemia. Ghrelin and DAG levels were also lower in females with OW/OB, but preprandial ghrelin proteolysis was not different between females with NW or OW/OB. Ghrelin and DAG levels decreased postprandially in males and females, independently of BMI, and ghrelin proteolysis increased postprandially-2 folds only in individuals with NW. Ghrelin des-acylation remained unaffected by BMI or feeding status in both sexes.Significance: Current study shows that ghrelin proteolysis increases in males with obesity as well as after meal in lean individuals. Therefore, ghrelin proteolysis may be an important checkpoint and, consequently, a putative pharmacological target to control circulating ghrelin levels in humans.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Ghrelin proteolysis
Ghrelin des-acylation
Obesity

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