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Iodine and other fa...
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Mathews, Divya M.Univ Auckland, Liggins Inst, Auckland, New Zealand.;Starship Childrens Hosp, Hlth New Zealand Te Whatu Ora, Auckland, New Zealand.
(author)
Iodine and other factors associated with fertility outcome following oil-soluble contrast medium hysterosalpingography : a prospective cohort study
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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Frontiers Media S.A.2024
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-535796
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-535796URI
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https://doi.org/10.3389/fendo.2024.1257888DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Objective: To examine factors associated with fertility following hysterosalpingography (HSG) using an oil-soluble contrast medium (OSCM).Design: In a prospective cohort study on 196 women undergoing OSCM HSG, we showed that iodine excess was almost universal (98%) and mild subclinical hypothyroidism was frequent (38%). Here, we report the analyses of secondary outcomes examining factors associated with the likelihood of pregnancy following the HSG.Setting: Auckland, New Zealand (2019-2021).Sample: 196 women with primary or secondary infertility who underwent OSCM HSG.Methods: Baseline and serial urine iodine concentrations (UIC) and thyroid function tests were measured over six months following the HSG. Pregnancy and treatment with levothyroxine during the study period were documented.Results: Following OSCM HSG, pregnancy rates were 49% in women aged <40 years (77/158) but considerably lower (16%) among those >= 40 years (6/38). Similarly, live birth rates were markedly lower in women >= 40 years (17%; 1/6) versus <40 years (73%; 56/77). 29% of participants were iodine deficient at baseline despite advice recommending iodine fortification. Following HSG, the likelihood of pregnancy in women with moderate iodine deficiency was 64% higher than in women with normal iodine levels (p=0.048). Among women aged <40 years who had subclinical hypothyroidism (n=75), levothyroxine treatment was associated with higher pregnancy rates compared to untreated women [63% (26/48) vs 37% (10/27), respectively; p=0.047].Conclusion: OSCM HSG was associated with higher pregnancy rates in women <= 40 than in those aged >40 years. Iodine deficiency was relatively common in this cohort, and increased iodine levels from OSCM exposure may contribute to the improved fertility observed with this procedure.
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Peart, Jane M.Auckland Radiol Grp, Auckland, New Zealand.
(author)
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Sim, Robert G.Auckland Radiol Grp, Auckland, New Zealand.
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Johnson, Neil P.Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.;Univ Auckland, Fac Med & Hlth Sci, Dept Obstet & Gynaecol, Auckland, New Zealand.;Repromed Auckland, Auckland, New Zealand.
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O'Sullivan, SusannahAuckland Dist Hlth Board, Endocrinol Greenlane Clin Ctr, Auckland, New Zealand.
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Derraik, José G. B.Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning,Univ Auckland, Fac Med & Hlth Sci, Dept Paediatrics: Child & Youth Hlth, Auckland, New Zealand.;Chiang Mai Univ, Res Inst Hlth Sci, Environm Occupat Hlth Sci & Noncommunicable Dis Re, Chiang Mai, Thailand.(Swepub:uu)josde820
(author)
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Hofman, Paul L.Univ Auckland, Liggins Inst, Auckland, New Zealand.;Starship Childrens Hosp, Hlth New Zealand Te Whatu Ora, Auckland, New Zealand.
(author)
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Univ Auckland, Liggins Inst, Auckland, New Zealand.;Starship Childrens Hosp, Hlth New Zealand Te Whatu Ora, Auckland, New Zealand.Auckland Radiol Grp, Auckland, New Zealand.
(creator_code:org_t)
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In:Frontiers in Endocrinology: Frontiers Media S.A.151664-2392
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