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Association between...
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Liang, Yannis YanGuangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, 102 Zhongshan Rd, Guangzhou, Guangdong, Peoples R China
(author)
Association between sleep duration and metabolic syndrome : linear and nonlinear Mendelian randomization analyses
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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2023-02-07
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BioMed Central (BMC),2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-498983
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-498983URI
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https://doi.org/10.1186/s12967-023-03920-2DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:151876754URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background Observational studies have found that both short and long sleep duration are associated with increased risk of metabolic syndrome (MetS). This study aimed to examine the associations of genetically determined sleep durations with MetS and its five components (i.e., central obesity, high blood pressure, dyslipidemia, hypertriglyceridemia, and hyperglycemia) among a group of elderly population.Methods In 335,727 participants of White British from the UK Biobank, linear Mendelian randomization (MR) methods were first employed to examine the causal association of genetically predicted continuous sleep duration with MetS and its each component. Nonlinear MR analyses were performed to determine the nonlinearity of these associations. The causal associations of short and long sleep duration with MetS and its components were further assessed by using genetic variants that associated with short (<= 6 h) and long sleep (>= 9 h) durations.Results Linear MR analyses demonstrated that genetically predicted 1-h longer sleep duration was associated with a 13% lower risk of MetS, a 30% lower risk of central obesity, and a 26% lower risk of hyperglycemia. Non-linear MR analyses provided evidence for non-linear associations of genetically predicted sleep duration with MetS and its five components (all P values < 0.008). Genetically predicted short sleep duration was moderately associated with MetS and its four components, including central obesity, dyslipidemia, hypertriglyceridemia, and hyperglycemia (all P values < 0.002), whereas genetically long sleep duration was not associated with MetS and any of its components.Conclusions Genetically predicted short sleep duration, but not genetically predicted long sleep duration, is a potentially causal risk factor for MetS.
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Chen, JieChinese Univ Hong Kong, Fac Med, Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit,Shatin, Hong Kong, Peoples R China
(author)
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Peng, MiaoguanGuangzhou Med Univ, Affiliated Hosp 3, Dept Endocrinol, Guangzhou, Guangdong, Peoples R China
(author)
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Zhou, JiajinKunming Univ Sci & Technol, Affiliated Hosp, Peoples Hosp Yunnan Prov 1, Kunming, Yunnan, Peoples R China
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Chen, XinruSouthern Med Univ, Sch Clin Med 1, Guangzhou, Peoples R China
(author)
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Tan, XiaoKarolinska Institutet,Uppsala universitet,Institutionen för medicinska vetenskaper,Zhejiang Univ, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Peoples R China.;Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Psychiat, Hangzhou, Peoples R China(Swepub:uu)xzata683
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Wang, NingjianShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai, Peoples R China
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Ma, HuanGuangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Guangzhou, Guangdong, Peoples R China
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Guo, LanGuangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Prov Key Lab Coronary Heart Dis Prevent, Guangzhou, Guangdong, Peoples R China
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Zhang, JihuiGuangzhou Med Univ, Affiliated Brain Hosp, Ctr Sleep & Circadian Med, 36 Mingxin Rd, Guangzhou, Guangdong, Peoples R China
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Wing, Yun-KwokChinese Univ Hong Kong, Fac Med, Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit,Shatin, Hong Kong, Peoples R China
(author)
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Geng, QingshanGuangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, 102 Zhongshan Rd, Guangzhou, Guangdong, Peoples R China.;Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Geriatr, Shenzhen, Guangdong, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Dept Geriatr, Shenzhen, Guangdong, Peoples R China
(author)
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Ai, SizhiGuangzhou Med Univ, Affiliated Brain Hosp, Ctr Sleep & Circadian Med, 36 Mingxin Rd, Guangzhou, Guangdong, Peoples R China.;Xinxiang Med Univ, Affiliated Hosp 1, Life Sci Ctr, Dept Cardiol,Heart Ctr, Weihui, Henan, Peoples R China
(author)
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Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, 102 Zhongshan Rd, Guangzhou, Guangdong, Peoples R ChinaChinese Univ Hong Kong, Fac Med, Dept Psychiat, Li Chiu Kong Family Sleep Assessment Unit,Shatin, Hong Kong, Peoples R China
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In:Journal of Translational Medicine: BioMed Central (BMC)21:11479-5876
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Liang, Yannis Ya ...
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Chen, Jie
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Peng, Miaoguan
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Zhou, Jiajin
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Chen, Xinru
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Tan, Xiao
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Wang, Ningjian
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Ma, Huan
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Guo, Lan
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Zhang, Jihui
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Wing, Yun-Kwok
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Geng, Qingshan
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Ai, Sizhi
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