Selective laser sintering additive manufacturing of dosage forms: Effect of powder formulation and process parameters on the physical properties of printed tablets

Tikhomirov, EvgeniiUppsala universitet,Nanoteknologi och funktionella material (författare)

Selective laser sintering additive manufacturing of dosage forms : Effect of powder formulation and process parameters on the physical properties of printed tablets

Large batches of placebo and drug-loaded solid dosage forms were successfully fabricated using selective laser sintering (SLS) 3D printing in this study. The tablet batches were prepared using either copovidone (N-vinyl-2-pyrrolidone and vinyl acetate, PVP/VA) or polyvinyl alcohol (PVA) and activated carbon (AC) as radiation absorbent, which was added to improve the sintering of the polymer. The physical properties of the dosage forms were evaluated at different pigment concentrations (i.e., 0.5 and 1.0 wt%) and at different laser energy inputs. The mass, hardness, and friability of the tablets were found to be tunable and structures with greater mass and mechanical strength were obtained with increasing carbon concentration and energy input. Amorphization of the active pharmaceutical ingredient in the drug-loaded batches, containing 10 wt% naproxen and 1 wt% AC, was achieved in-situ during printing. Thus, amorphous solid dispersions were prepared in a single-step process and produced tablets with mass losses below 1 wt%. These findings show how the properties of dosage forms can be tuned by careful selection of the process parameters and the powder formulation. SLS 3D printing can therefore be considered to be an interesting and promising technique for the fabrication of personalized medicines.

TEKNIK OCH TEKNOLOGIER Nanoteknik hsv//swe
ENGINEERING AND TECHNOLOGY Nano-technology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
Additive manufacturing
Drug manufacturing
Personalized medicines
Selective laser sintering
Three-dimensional printing
Teknisk fysik med inriktning mot nanoteknologi och funktionella material
Engineering Science with specialization in Nanotechnology and Functional Materials

Åhlén, MichelleUppsala universitet,Nanoteknologi och funktionella material(Swepub:uu)micah729 (författare)
Di Gallo, Nicole (författare)
Strømme, Maria,1970-Uppsala universitet,Nanoteknologi och funktionella material(Swepub:uu)mst26208 (författare)
Kipping, Thomas (författare)
Quodbach, Julian (författare)
Lindh, Jonas,1977-Uppsala universitet,Nanoteknologi och funktionella material(Swepub:uu)jolin193 (författare)
Uppsala universitetNanoteknologi och funktionella material (creator_code:org_t)

Av författaren/redakt...: Tikhomirov, Evge ...; Åhlén, Michelle; Di Gallo, Nicole; Strømme, Maria, ...; Kipping, Thomas; Quodbach, Julian; visa fler...; Lindh, Jonas, 19 ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Farmaceutiska ve ...

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