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Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases : a systematic literature review informing EULAR points to consider
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- Rodriguez-Carrio, Javier (författare)
- Univ Oviedo, Area Immunol, Inst Invest Sanitaria Principado Asturias ISPA, Asturias, Spain.
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- Burska, Agata (författare)
- Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England.;NIHR Leeds Biomed Res Ctr, Leeds, England.
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- Conaghan, P. G. (författare)
- Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England.;NIHR Leeds Biomed Res Ctr, Leeds, England.
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- Dik, Willem A. (författare)
- Univ Med Ctr Rotterdam, Dept Immunol, Lab Med Immunol, Erasmus MC, Rotterdam, Netherlands.
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- Biesen, Robert (författare)
- Charite Univ Med Berlin, Dept Rheumatol, Berlin, Germany.
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- Eloranta, Maija-Leena (författare)
- Uppsala universitet,Reumatologi
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- Cavalli, Giulio (författare)
- Univ Vita Salute San Raffaele, Unit Immunol Rheumatol Allergy & Rare Dis, Milan, Italy.
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- Visser, Marianne (författare)
- EULAR, PARE Patient Res Partners, Amsterdam, Netherlands.
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- Boumpas, Dimitrios T. (författare)
- Univ Crete, Med Sch, Dept Internal Med, Iraklion, Greece.
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- Bertsias, George (författare)
- Univ Crete, Med Sch, Dept Rheumatol Clin Immunol, Iraklion, Greece.
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- Wahren-Herlenius, Marie (författare)
- Karolinska Institutet,Karolinska Inst, Div Rheumatol, Stockholm, Sweden.;Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.
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- Rehwinkel, Jan (författare)
- Univ Oxford, Med Res Council Weatherall Inst Mol Med, Radcliffe Dept Med, Med Res Council Human Immunol Unit, Oxford, England.
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- Fremond, Marie-Louise (författare)
- Univ Paris Cite, Hop Necker Enfants Malad, Immuno Hematol & Rhumatol Pediat, Paris, France.
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- Crow, Mary K. (författare)
- Weill Cornell Med Coll, Hosp Special Surg, Mary Kirkland Ctr Lupus Res, New York, NY USA.
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- Rönnblom, Lars (författare)
- Uppsala universitet,Reumatologi
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- Vital, Ed (författare)
- Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England.;NIHR Leeds Biomed Res Ctr, Leeds, England.
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- Versnel, Marjan (författare)
- Univ Med Ctr Rotterdam, Dept Immunol, Erasmus MC, Rotterdam, Netherlands.
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Univ Oviedo, Area Immunol, Inst Invest Sanitaria Principado Asturias ISPA, Asturias, Spain Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England.;NIHR Leeds Biomed Res Ctr, Leeds, England. (creator_code:org_t)
- 2023-03-07
- 2023
- Engelska.
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Ingår i: RMD Open. - : BMJ Publishing Group Ltd. - 2056-5933. ; 9:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BackgroundType I interferons (IFN-I) contribute to a broad range of rheumatic and musculoskeletal diseases (RMDs). Compelling evidence suggests that the measurement of IFN-I pathway activation may have clinical value. Although several IFN-I pathway assays have been proposed, the exact clinical applications are unclear. We summarise the evidence on the potential clinical utility of assays measuring IFN-I pathway activation.MethodsA systematic literature review was conducted across three databases to evaluate the use of IFN-I assays in diagnosis and monitor disease activity, prognosis, response to treatment and responsiveness to change in several RMDs.ResultsOf 366 screened, 276 studies were selected that reported the use of assays reflecting IFN-I pathway activation for disease diagnosis (n=188), assessment of disease activity (n=122), prognosis (n=20), response to treatment (n=23) and assay responsiveness (n=59). Immunoassays, quantitative PCR (qPCR) and microarrays were reported most frequently, while systemic lupus erythematosus (SLE), rheumatoid arthritis, myositis, systemic sclerosis and primary Sjogren's syndrome were the most studied RMDs. The literature demonstrated significant heterogeneity in techniques, analytical conditions, risk of bias and application in diseases. Inadequate study designs and technical heterogeneity were the main limitations. IFN-I pathway activation was associated with disease activity and flare occurrence in SLE, but their incremental value was uncertain. IFN-I pathway activation may predict response to IFN-I targeting therapies and may predict response to different treatments.ConclusionsEvidence indicates potential clinical value of assays measuring IFN-I pathway activation in several RMDs, but assay harmonisation and clinical validation are urged. This review informs the EULAR points to consider for the measurement and reporting of IFN-I pathway assays.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- cytokines
- arthritis
- rheumatoid
- autoimmunity
- immune system diseases
- lupus erythematosus
- systemic
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Rodriguez-Carrio ...
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Burska, Agata
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Conaghan, P. G.
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Dik, Willem A.
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Biesen, Robert
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Eloranta, Maija- ...
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Cavalli, Giulio
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Visser, Marianne
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Boumpas, Dimitri ...
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Bertsias, George
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Wahren-Herlenius ...
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Rehwinkel, Jan
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Fremond, Marie-L ...
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Crow, Mary K.
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Rönnblom, Lars
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Vital, Ed
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Versnel, Marjan
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