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Type I interferon p...
Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases : a systematic literature review informing EULAR points to consider
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- Burska, Agata (författare)
- Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England.;NIHR Leeds Biomed Res Ctr, Leeds, England.
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- Rodriguez-Carrio, Javier (författare)
- Univ Oviedo, Area Immunol, Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain.
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- Biesen, Robert (författare)
- Charite Univ Med Berlin, Dept Rheumatol, Berlin, Germany.
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- Dik, Willem A. (författare)
- Univ Med Ctr Rotterdam, Erasmus MC, Dept Immunol, Lab Med Immunol,Netherlands Immunol, Rotterdam, Netherlands.
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- Eloranta, Maija-Leena (författare)
- Uppsala universitet,Reumatologi
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- Cavalli, Giulio (författare)
- Univ Vita Salute San Raffaele, Unit Immunol Rheumatol Allergy & Rare Dis, Milan, Italy.;EULAR, PARE Patient Res Partners, Amsterdam, Netherlands.
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- Visser, Marianne (författare)
- Univ Crete, Med Sch, Dept Internal Med, Iraklion, Greece.
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- Boumpas, Dimitrios T. (författare)
- Univ Crete, Med Sch, Dept Rheumatol Clin Immunol, Iraklion, Greece.
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- Bertsias, George (författare)
- Univ Crete, Med Sch, Dept Rheumatol Clin Immunol, Iraklion, Greece.
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- Wahren-Herlenius, Marie (författare)
- Karolinska Institutet
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- Rehwinkel, Jan (författare)
- Univ Oxford, Med Res Council Weatherall Inst Mol Med, Med Res Council Human Immunol Unit, Radcliffe Dept Med, Oxford, England.
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Fremond, Marie-Louise (författare)
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- Crow, Mary K. (författare)
- Hosp Special Surg, Weill Cornell Med Coll, Mary Kirkland Ctr Lupus Res, New York, NY USA.
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- Rönnblom, Lars (författare)
- Uppsala universitet,Reumatologi
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- Conaghan, P. G. (författare)
- Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England.;NIHR Leeds Biomed Res Ctr, Leeds, England.
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- Versnel, Marjan (författare)
- Erasmus MC, Dept Immunol, Rotterdam, Netherlands.
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- Vital, Ed (författare)
- Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England.;NIHR Leeds Biomed Res Ctr, Leeds, England.
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Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England;NIHR Leeds Biomed Res Ctr, Leeds, England. Univ Oviedo, Area Immunol, Inst Invest Sanitaria Principado Asturias ISPA, Oviedo, Spain. (creator_code:org_t)
- 2023-03-02
- 2023
- Engelska.
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Ingår i: RMD Open. - : BMJ Publishing Group Ltd. - 2056-5933. ; 9:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- ObjectivesTo systematically review the literature for assay methods that aim to evaluate type I interferon (IFN-I) pathway activation and to harmonise-related terminology.MethodsThree databases were searched for reports of IFN-I and rheumatic musculoskeletal diseases. Information about the performance metrics of assays measuring IFN-I and measures of truth were extracted and summarised. A EULAR task force panel assessed feasibility and developed consensus terminology.ResultsOf 10 037 abstracts, 276 fulfilled eligibility criteria for data extraction. Some reported more than one technique to measure IFN-I pathway activation. Hence, 276 papers generated data on 412 methods. IFN-I pathway activation was measured using: qPCR (n=121), immunoassays (n=101), microarray (n=69), reporter cell assay (n=38), DNA methylation (n=14), flow cytometry (n=14), cytopathic effect assay (n=11), RNA sequencing (n=9), plaque reduction assay (n=8), Nanostring (n=5), bisulphite sequencing (n=3). Principles of each assay are summarised for content validity. Concurrent validity (correlation with other IFN assays) was presented for n=150/412 assays. Reliability data were variable and provided for 13 assays. Gene expression and immunoassays were considered most feasible. Consensus terminology to define different aspects of IFN-I research and practice was produced.ConclusionsDiverse methods have been reported as IFN-I assays and these differ in what elements or aspects of IFN-I pathway activation they measure and how. No 'gold standard' represents the entirety of the IFN pathway, some may not be specific for IFN-I. Data on reliability or comparing assays were limited, and feasibility is a challenge for many assays. Consensus terminology should improve consistency of reporting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Arthritis
- Rheumatoid
- Cytokines
- Inflammation
- Lupus Erythematosus
- Systemic
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Burska, Agata
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Rodriguez-Carrio ...
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Biesen, Robert
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Dik, Willem A.
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Eloranta, Maija- ...
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Cavalli, Giulio
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Visser, Marianne
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Boumpas, Dimitri ...
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Bertsias, George
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Wahren-Herlenius ...
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Rehwinkel, Jan
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Fremond, Marie-L ...
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Crow, Mary K.
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Rönnblom, Lars
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Conaghan, P. G.
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Versnel, Marjan
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Vital, Ed
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