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Amelioration of lip...
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Kumari, KhushbuKIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.
(författare)
Amelioration of lipopeptide biosurfactants for enhanced antibacterial and biocompatibility through molecular antioxidant property by methoxy and carboxyl moieties
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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Elsevier,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-500301
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-500301URI
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https://doi.org/10.1016/j.biopha.2023.114493DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Biosurfactants having surface-active biomolecules have been the cynosure in environment research due to their vast application. However, the lack of information about their low-cost production and detailed mechanistic biocompatibility limits the applicability. The study explores techniques for the production and design of lowcost, biodegradable, and non-toxic biosurfactants from Brevibacterium casei strain LS14 and excavates the mechanistic details of their biomedical properties like antibacterial effects and biocompatibility. Taguchi's design of experiment was used to optimize for enhancing biosurfactant production by optimal factor combinations like Waste glycerol (1%v/v), peptone (1%w/v), NaCl 0.4% (w/v), and pH 6. Under optimal conditions, the purified biosurfactant reduced the surface tension to 35 mN/m from 72.8 mN/m (MSM) and a critical micelle concentration of 25 mg/ml was achieved. Spectroscopic analyses of the purified biosurfactant using Nuclear Magnetic Resonance suggested it as a lipopeptide biosurfactant. The evaluation of mechanistic antibacterial, antiradical, antiproliferative, and cellular effects indicated the efficient antibacterial activity (against Pseudomonas aeruginosa) of biosurfactants due to free radical scavenging activity and oxidative stress. Moreover, the cellular cytotoxicity was estimated by MTT and other cellular assays revealing the phenomenon as the dosedependent induction of apoptosis due to free radical scavenging with an LC50 of 55.6 +/- 2.3 mg/ml.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Behera, Himadri TanayaKIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.
(författare)
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Nayak, Priyadarshini PratikshyaKIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.
(författare)
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Sinha, AdrijaKIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.
(författare)
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Nandi, AdityaKIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.
(författare)
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Ghosh, AisheeKIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.
(författare)
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Saha, UtsaKIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.
(författare)
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Suar, MrutyunjayKIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.
(författare)
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Panda, Pritam Kumar,PhD Student,1991-Uppsala universitet,Materialteori(Swepub:uu)pripa793
(författare)
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Verma, Suresh K.KIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.
(författare)
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Raina, VishakhaKIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.
(författare)
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KIIT DU, Sch Biotechnol, Bhubaneswar 751024, India.Materialteori
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Biomedicine and Pharmacotherapy: Elsevier1610753-33221950-6007
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Kumari, Khushbu
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Behera, Himadri ...
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Nayak, Priyadars ...
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Sinha, Adrija
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Nandi, Aditya
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Ghosh, Aishee
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Saha, Utsa
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Suar, Mrutyunjay
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Panda, Pritam Ku ...
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Verma, Suresh K.
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Raina, Vishakha
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