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Is styrene competit...
Is styrene competitive for dopamine receptor binding?
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- De Santis, Emiliano, PhD (författare)
- Uppsala universitet,Biokemi,Institutionen för fysik och astronomi
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- Minicozzi, Velia (författare)
- Department of Physics, University of Rome Tor Vergata and Istituto di Fisica Nucleare (INFN), Via della Ricerca Scientifica 1 , 00133 Roma , Italy
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- Rossi, Giancarlo (författare)
- Hystorical Museum for Physics and Enrico Fermi Studies and Research Center, Department of Physics, University of Rome Tor Vergata and Istituto di Fisica Nucleare (INFN), Via della Ricerca Scientifica 1 , 00133 Roma , Italy;Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Via Panisperna 89a , 00184 Roma , Italy
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- Stellato, Francesco (författare)
- Department of Physics, University of Rome Tor Vergata and Istituto di Fisica Nucleare (INFN), Via della Ricerca Scientifica 1 , 00133 Roma , Italy
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- Morante, Silvia (författare)
- Department of Physics, University of Rome Tor Vergata and Istituto di Fisica Nucleare (INFN), Via della Ricerca Scientifica 1 , 00133 Roma , Italy
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(creator_code:org_t)
- 2022-04-08
- 2022
- Engelska.
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Ingår i: Biomolecular Concepts. - : Walter de Gruyter. - 1868-503X. ; 13:1, s. 200-206
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The potential role of styrene oxide in altering the dopaminergic pathway in the ear is investigated by means of molecular docking and molecular dynamics simulations. We estimate the binding affinity of both styrene oxide and dopamine to the dopaminergic receptor DrD2 by computing the free-energy difference, ∆G, between the configuration where the ligand is bound to the receptor and the situation in which it is “infinitely” far away from it. The results show that the styrene oxide has a somewhat lower affinity for binding with respect to dopamine, which, however, may not be enough to prevent exogenous high concentration styrene oxide to compete with endogenous dopamine for DrD2 binding.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
Nyckelord
- umbrella sampling
- dopamine
- styrene oxide
- binding affinity
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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