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Acute nicotine expo...
Acute nicotine exposure blocks aromatase in the limbic brain of healthy women : A [11C]cetrozole PET study
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- Dubol, Manon (author)
- Uppsala universitet,Neuropsykofarmakologi,Science for Life Laboratory, SciLifeLab
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- Immenschuh, Jana (author)
- Uppsala universitet,Neuropsykofarmakologi,Science for Life Laboratory, SciLifeLab
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- Jonasson, My (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Takahashi, Kayo (author)
- RIKEN Ctr Biosyst Dynam Res, Kobe, Japan.
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- Niwa, Takashi (author)
- RIKEN Ctr Biosyst Dynam Res, Kobe, Japan.;Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Tokyo, Japan.
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- Hosoya, Takamitsu (author)
- RIKEN Ctr Biosyst Dynam Res, Kobe, Japan.;Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Tokyo, Japan.
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- Roslin, Sara (author)
- Uppsala universitet,Preparativ läkemedelskemi
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- Wikström, Johan, Professor, 1964- (author)
- Uppsala universitet,Radiologi
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- Antoni, Gunnar (author)
- Uppsala universitet,Preparativ läkemedelskemi
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- Watanabe, Yasuyoshi (author)
- RIKEN Ctr Biosyst Dynam Res, Kobe, Japan.
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- Lubberink, Mark (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Biegon, Anat (author)
- SUNY Stony Brook, Dept Radiol & Neurol, Sch Med, Stony Brook, NY USA.
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- Sundström Poromaa, Inger, 1964- (author)
- Uppsala universitet,Reproduktiv hälsa
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- Comasco, Erika, 1982- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuropsykofarmakologi
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
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In: Comprehensive Psychiatry. - : Elsevier. - 0010-440X .- 1532-8384. ; 123
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https://uu.diva-port... (primary) (Raw object)
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Abstract
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- Background: Of interest to women's mental health, a wealth of studies suggests sex differences in nicotine addiction and treatment response, but their psychoneuroendocrine underpinnings remain largely unknown. A pathway involving sex steroids could indeed be involved in the behavioural effects of nicotine, as it was found to inhibit aromatase in vitro and in vivo in rodents and non-human primates, respectively. Aromatase regulates the synthesis of oestrogens and, of relevance to addiction, is highly expressed in the limbic brain.Methods: The present study sought to investigate in vivo aromatase availability in relation to exposure to nicotine in healthy women. Structural magnetic resonance imaging and two [11C]cetrozole positron emission tomography (PET) scans were performed to assess the availability of aromatase before and after administration of nicotine. Gonadal hormones and cotinine levels were measured. Given the region-specific expression of aromatase, a ROI -based approach was employed to assess changes in [11C]cetrozole non-displaceable binding potential.Results: The highest availability of aromatase was found in the right and left thalamus. Upon nicotine exposure, [11C]cetrozole binding in the thalamus was acutely decreased bilaterally (Cohen's d =-0.99). In line, cotinine levels were negatively associated with aromatase availability in the thalamus, although as non-significant trend.Conclusions: These findings indicate acute blocking of aromatase availability by nicotine in the thalamic area. This suggests a new putative mechanism mediating the effects of nicotine on human behaviour, particularly relevant to sex differences in nicotine addiction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Addiction
- Aromatase
- Brain
- Nicotine
- PET
- Women
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Dubol, Manon
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Immenschuh, Jana
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Jonasson, My
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Takahashi, Kayo
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Niwa, Takashi
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Hosoya, Takamits ...
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show more...
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Roslin, Sara
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Wikström, Johan, ...
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Antoni, Gunnar
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Watanabe, Yasuyo ...
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Lubberink, Mark
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Biegon, Anat
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Sundström Poroma ...
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Comasco, Erika, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Comprehensive Ps ...
- By the university
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Uppsala University