Sökning: WFRF:(Jonasson My) >
Acute nicotine expo...
Acute nicotine exposure blocks aromatase in the limbic brain of healthy women : A [11C]cetrozole PET study
-
- Dubol, Manon (författare)
- Uppsala universitet,Neuropsykofarmakologi,Science for Life Laboratory, SciLifeLab
-
- Immenschuh, Jana (författare)
- Uppsala universitet,Neuropsykofarmakologi,Science for Life Laboratory, SciLifeLab
-
- Jonasson, My (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
-
visa fler...
-
- Takahashi, Kayo (författare)
- RIKEN Ctr Biosyst Dynam Res, Kobe, Japan.
-
- Niwa, Takashi (författare)
- RIKEN Ctr Biosyst Dynam Res, Kobe, Japan.;Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Tokyo, Japan.
-
- Hosoya, Takamitsu (författare)
- RIKEN Ctr Biosyst Dynam Res, Kobe, Japan.;Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Tokyo, Japan.
-
- Roslin, Sara (författare)
- Uppsala universitet,Preparativ läkemedelskemi
-
- Wikström, Johan, Professor, 1964- (författare)
- Uppsala universitet,Radiologi
-
- Antoni, Gunnar (författare)
- Uppsala universitet,Preparativ läkemedelskemi
-
- Watanabe, Yasuyoshi (författare)
- RIKEN Ctr Biosyst Dynam Res, Kobe, Japan.
-
- Lubberink, Mark (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
-
- Biegon, Anat (författare)
- SUNY Stony Brook, Dept Radiol & Neurol, Sch Med, Stony Brook, NY USA.
-
- Sundström Poromaa, Inger, 1964- (författare)
- Uppsala universitet,Reproduktiv hälsa
-
- Comasco, Erika, 1982- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuropsykofarmakologi
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
-
Ingår i: Comprehensive Psychiatry. - : Elsevier. - 0010-440X .- 1532-8384. ; 123
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Of interest to women's mental health, a wealth of studies suggests sex differences in nicotine addiction and treatment response, but their psychoneuroendocrine underpinnings remain largely unknown. A pathway involving sex steroids could indeed be involved in the behavioural effects of nicotine, as it was found to inhibit aromatase in vitro and in vivo in rodents and non-human primates, respectively. Aromatase regulates the synthesis of oestrogens and, of relevance to addiction, is highly expressed in the limbic brain.Methods: The present study sought to investigate in vivo aromatase availability in relation to exposure to nicotine in healthy women. Structural magnetic resonance imaging and two [11C]cetrozole positron emission tomography (PET) scans were performed to assess the availability of aromatase before and after administration of nicotine. Gonadal hormones and cotinine levels were measured. Given the region-specific expression of aromatase, a ROI -based approach was employed to assess changes in [11C]cetrozole non-displaceable binding potential.Results: The highest availability of aromatase was found in the right and left thalamus. Upon nicotine exposure, [11C]cetrozole binding in the thalamus was acutely decreased bilaterally (Cohen's d =-0.99). In line, cotinine levels were negatively associated with aromatase availability in the thalamus, although as non-significant trend.Conclusions: These findings indicate acute blocking of aromatase availability by nicotine in the thalamic area. This suggests a new putative mechanism mediating the effects of nicotine on human behaviour, particularly relevant to sex differences in nicotine addiction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Addiction
- Aromatase
- Brain
- Nicotine
- PET
- Women
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Dubol, Manon
-
Immenschuh, Jana
-
Jonasson, My
-
Takahashi, Kayo
-
Niwa, Takashi
-
Hosoya, Takamits ...
-
visa fler...
-
Roslin, Sara
-
Wikström, Johan, ...
-
Antoni, Gunnar
-
Watanabe, Yasuyo ...
-
Lubberink, Mark
-
Biegon, Anat
-
Sundström Poroma ...
-
Comasco, Erika, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Psykiatri
- Artiklar i publikationen
-
Comprehensive Ps ...
- Av lärosätet
-
Uppsala universitet