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Diabetes mellitus i...
Diabetes mellitus in dog - : No evidence for a type-1-like phenotype
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- Ahlgren, Kerstin. M (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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Fall, Tove (author)
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Landegren, Nils (author)
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von Euler, Henrik (author)
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Sundberg, Katarina (author)
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Lindblad-Toh, Kerstin (author)
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Lobell, Anna (author)
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Hedhammar, Åke (author)
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Andersson, Göran (author)
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Hansson-Hamlin, Helene (author)
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Lernmark, Åke (author)
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Kämpe, Olle (author)
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(creator_code:org_t)
- English.
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Aims/hypothesis Diabetes mellitus (DM) is one of the most common endocrine disorders in dogs, and is commonly proposed to be of autoimmune origin. Although the clinical symptoms of human type 1 diabetes (T1D) and canine DM are similar, the aetiologies may differ. The aim of this study was to investigate if autoimmune aetiology resembling human T1D is as prevalent in dogs as previously reported. Methods Sera from 121 diabetic dogs representing 38 different breeds were tested for islet cell antibodies (ICA) and GAD65 autoantibodies (GADA) and compared with sera from 133 healthy dogs from 40 breeds. ICA was detected by indirect immunofluorescence using both canine and human frozen sections. GADA was detected by in vitro transcription and translation (ITT) of human and canine GAD65, followed by immunoprecipitation. Results None of the canine sera analyzed tested positive for ICA on sections of frozen canine or human ICA pancreas. However, serum from one diabetic dog was weakly positive in the canine GADA assay and serum from one healthy dog was weakly positive in the human GADA assay. Conclusions/interpretations Based on sera from 121 diabetic dogs from 38 different breeds were tested for humoral autoreactivity using four different assays, contrary to previous observations, we find no support for an autoimmune aetiology in canine diabetes.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- Autoimmunity
- autoantibodies
- canine
- diabetes mellitus
- GAD65
- ICA
- Medicin
- Medicine
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database
- By the author/editor
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Ahlgren, Kerstin ...
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Fall, Tove
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Landegren, Nils
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von Euler, Henri ...
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Sundberg, Katari ...
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Lindblad-Toh, Ke ...
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show more...
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Lobell, Anna
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Hedhammar, Åke
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Andersson, Göran
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Hansson-Hamlin, ...
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Lernmark, Åke
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Kämpe, Olle
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
- By the university
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Uppsala University