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Allergic sensitisat...
Allergic sensitisation and type-2 inflammation is associated with new-onset and persistent allergic disease
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- Blöndal, Viiu (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Sundbom, Fredrik (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Zhou, Xingwu (författare)
- Uppsala universitet,Klinisk fysiologi,Lung- allergi- och sömnforskning
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- Movérare, Robert (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,Thermo Fischer Sci, Uppsala, Sweden.
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- Borres, Magnus P, 1956- (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa,Thermo Fischer Sci, Uppsala, Sweden.
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- Högman, Marieann (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Alving, Kjell, 1959- (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- Malinovschi, Andrei, 1978- (författare)
- Uppsala universitet,Klinisk fysiologi,Lung- allergi- och sömnforskning
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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(creator_code:org_t)
- Wiley-Blackwell, 2023
- 2023
- Engelska.
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Ingår i: Clinical and Translational Allergy. - : Wiley-Blackwell. - 2045-7022. ; 13:4
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Allergic disease is common. The aim of this study was to look at the change in asthma and rhinitis over time and to characterise factors contributing to remission and persistence of disease.Methods: This cohort study included 255 individuals with or without asthma and or rhinitis that participated in a population survey and a follow-up 10 years later. The participants were tested for allergic sensitisation, total IgE, multiplex allergen component analysis and type-2 inflammatory markers: exhaled nitric oxide (FENO), eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN).Results: Of the 132 healthy individuals, 112 remained healthy, 16 developed rhinitis, 4 asthma and rhinitis over the 10 years. Out of 82 subjects with rhinitis, 26 went into remission, 53 remained unchanged and 3 developed asthma in addition to rhinitis. None of the 41 participants with asthma and rhinitis went into remission. Subjects with persistent rhinitis and asthma had higher levels of total IgE (odds ratio [OR] 95% confidence interval [CI]: 6.16 [3.05-12.5]) at baseline and after 10 years, and FENO and ECP at baseline (OR per log unit increase, 95% CI 5.21 [1.20-22.7] and 6.32 [1.52-26.4], respectively), compared with those that remained healthy. Subjects with persistent rhinitis were more likely to be sensitised to grass pollen and had higher total IgE levels than those that went into remission. Individuals with persistent asthma were more likely to be sensitised to tree pollen and furry animals than those with only persistent rhinitis (OR 95% CI: 3.50 [1.29-9.49] and 6.73 [2.00-22.6], respectively).Conclusion: IgE sensitisation and total IgE levels are associated with the persistence of rhinitis and asthma. Participants with persistent allergic disease had higher levels of allergen sensitisation and type 2 inflammation markers at baseline than those who remained healthy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- asthma
- ENT
- epidemiology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Blöndal, Viiu
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Sundbom, Fredrik
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Zhou, Xingwu
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Movérare, Robert
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Borres, Magnus P ...
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Högman, Marieann
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visa fler...
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Alving, Kjell, 1 ...
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Malinovschi, And ...
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Janson, Christer
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Lungmedicin och ...
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Clinical and Tra ...
- Av lärosätet
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Uppsala universitet