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Pennisetum glaucum ...
Pennisetum glaucum Protein Extract Protects RBC, Liver, Kidney, Small Intestine from Oxidative Damage and Exhibits Anticoagulant, Antiplatelet Activity
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- Shivaiah, Ashwini (författare)
- Tumkur Univ, Dept Studies & Res Biochem, Tumkur, India.;Tumkur Univ, Ctr Biosci & Innovat, Tumkur, India.
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- Srinivsa, Chandramma (författare)
- Tumkur Univ, Dept Studies & Res Biochem, Tumkur, India.;Tumkur Univ, Ctr Biosci & Innovat, Tumkur, India.
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- Hanumegowda, Sujatha M. (författare)
- Kuvempu Univ, Dept Biochem Jnansahydri, Shivamogga, India. Uppsala Biomed Ctr, Dept Med Biochem & Microbiol IMBM, Uppsala, Sweden. Liveon Biolabs Pvt Ltd, Tumkur, India.
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- Kengaiah, Jayanna (författare)
- Tumkur Univ, Dept Studies & Res Biochem, Tumkur, India.;Tumkur Univ, Ctr Biosci & Innovat, Tumkur, India.
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- Nandish, Sharath Kumar M. (författare)
- Tumkur Univ, Dept Studies & Res Biochem, Tumkur, India.;Tumkur Univ, Ctr Biosci & Innovat, Tumkur, India.
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- Ramachandraiah, Chethana (författare)
- Tumkur Univ, Dept Studies & Res Biochem, Tumkur, India.;Tumkur Univ, Ctr Biosci & Innovat, Tumkur, India.
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- Santosh, M. Sebastin (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Gowda, Thippeswamy Thippande (författare)
- Tumkur Univ, Ctr Biosci & Innovat, Tumkur, India.
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Rajesh, R. (författare)
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- Shinde, Manohar (författare)
- Tumkur Univ, Dept Studies & Res Biochem, Tumkur, India.;Tumkur Univ, Ctr Biosci & Innovat, Tumkur, India.;Tumkur Univ, Dept Studies & Res Biochem, B H Rd, Tumkur 572103, India.
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- Sannaningaiah, Devaraja (författare)
- Tumkur Univ, Dept Studies & Res Biochem, Tumkur, India.;Tumkur Univ, Ctr Biosci & Innovat, Tumkur, India.;Tumkur Univ, Dept Studies & Res Biochem, B H Rd, Tumkur 572103, India.
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Tumkur Univ, Dept Studies & Res Biochem, Tumkur, India;Tumkur Univ, Ctr Biosci & Innovat, Tumkur, India. Kuvempu Univ, Dept Biochem Jnansahydri, Shivamogga, India. Uppsala Biomed Ctr, Dept Med Biochem & Microbiol IMBM, Uppsala, Sweden. Liveon Biolabs Pvt Ltd, Tumkur, India. (creator_code:org_t)
- 2022-12-09
- 2023
- Engelska.
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Ingår i: JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION. - : Taylor & Francis. - 2769-7061 .- 2769-707X. ; 42:3, s. 211-223
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: High level of exogenous ROS in the circulation affects RBC membrane integrity which facilitates the generation of endogenous RBC ROS, implicated in series of physiological changes primarily associated with thrombosis and vital tissue damage. Although, Pennisetum glaucum (pearl millet) stores abundance of proteins, their therapeutic potential is least explored. Thus, the purpose of this study is to examine the role of Pennisetum Glaucum Protein Extract (PGE) on oxidative stress induced cell/tissue damage and thrombosis.Method: In this investigation, protein characterization was done by using SDS-PAGE, Native-PAGE, PAS-staining and HPLC. In-vitro oxidative stress was induced in RBC using sodium nitrite. While, in-vivo oxidative stress was induced in experimental rats using diclofenac. Stress markers and biochemical parameters were evaluated. Role of PGE on thrombosis was assessed by using, in-vitro plasma recalcification time, activated partial thromboplastin time, prothrombin time, mouse tail bleeding time (In-vivo) and platelet aggregation.Results: PGE revealed varied range of molecular weight proteins on SDS-PAGE. PGE normalized the sodium nitrite induced oxidative damage of RBC and diclofenac induced oxidative damage in liver, kidney and small intestine. PGE exhibited anticoagulant effect by increasing the coagulation time of both PRP and PPP and mouse tail bleeding time. Furthermore, PGE prolonged the clotting time of only APTT but did not affect PT. PGE inhibited agonists ADP and epinephrine induced platelet aggregation.Conclusion: Our findings suggest, PGE could be a better contender in the management of oxidative stress and its associated diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Oxidative stress
- thrombosis
- pearl millet proteins
- anticoagulant
- antiplatelet
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Shivaiah, Ashwin ...
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Srinivsa, Chandr ...
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Hanumegowda, Suj ...
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Kengaiah, Jayann ...
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Nandish, Sharath ...
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Ramachandraiah, ...
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Santosh, M. Seba ...
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Gowda, Thippeswa ...
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Rajesh, R.
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Shinde, Manohar
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Sannaningaiah, D ...
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Uppsala universitet