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Obesity Is Associat...
Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue
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- Meen, Astri J. (författare)
- UIT Arctic Univ Norway, Dept Med Biol, N-9019 Tromso, Norway.
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- Doncheva, Atanaska I. (författare)
- Univ Oslo, Dept Nutr, N-0316 Oslo, Norway.
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- Boettcher, Yvonne (författare)
- Akershus Univ, Med Div, EpiGen, Hosp, N-1474 Nordbyhagen, Norway.;Akershus Univ Hosp, Dept Endocrinol, Div Med, N-1478 Lorenskog, Norway.
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- Dankel, Simon N. (författare)
- Univ Bergen, Dept Clin Sci, Mohn Nutr Res Lab, N-5020 Bergen, Norway.;Haukeland Hosp, Dept Med Biochem & Pharmacol, Hormone Lab, N-5020 Bergen, Norway.
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- Hoffmann, Anne (författare)
- Univ Leipzig, Helmholtz Inst Metab Obes & Vasc Res HI MAG, Helmholtz Zent Munchen, D-04103 Leipzig, Germany.;Univ Hosp Leipzig, D-04103 Leipzig, Germany.
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- Blueher, Matthias (författare)
- Univ Leipzig, Helmholtz Inst Metab Obes & Vasc Res HI MAG, Helmholtz Zent Munchen, D-04103 Leipzig, Germany.;Univ Hosp Leipzig, D-04103 Leipzig, Germany.;Univ Leipzig Med Ctr, Med Dept III Endocrinol Nephrol Rheumatol, D-04103 Leipzig, Germany.
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- Ferno, Johan (författare)
- Univ Bergen, Dept Clin Sci, Mohn Nutr Res Lab, N-5020 Bergen, Norway.;Haukeland Hosp, Dept Med Biochem & Pharmacol, Hormone Lab, N-5020 Bergen, Norway.
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- Mellgren, Gunnar (författare)
- Univ Bergen, Dept Clin Sci, Mohn Nutr Res Lab, N-5020 Bergen, Norway.;Haukeland Hosp, Dept Med Biochem & Pharmacol, Hormone Lab, N-5020 Bergen, Norway.
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- Ghosh, Adhideb (författare)
- Univ Leipzig Med Ctr, Med Dept III Endocrinol Nephrol Rheumatol, D-04103 Leipzig, Germany.
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- Sun, Wenfei (författare)
- Swiss Fed Inst Technol, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland.
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- Dong, Hua (författare)
- Swiss Fed Inst Technol, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland.
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- Noe, Falko (författare)
- Swiss Fed Inst Technol, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland.
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- Wolfrum, Christian (författare)
- Swiss Fed Inst Technol, Inst Food Nutr & Hlth, CH-8092 Zurich, Switzerland.
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- Pejler, Gunnar (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Dalen, Knut Tomas (författare)
- Univ Oslo, Dept Nutr, N-0316 Oslo, Norway.
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- Kolset, Svein O. (författare)
- Univ Oslo, Dept Nutr, N-0316 Oslo, Norway.
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UIT Arctic Univ Norway, Dept Med Biol, N-9019 Tromso, Norway Univ Oslo, Dept Nutr, N-0316 Oslo, Norway. (creator_code:org_t)
- MDPI, 2023
- 2023
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 24:8
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Proteoglycans are central components of the extracellular matrix (ECM) and binding partners for inflammatory chemokines. Morphological differences in the ECM and increased inflammation are prominent features of the white adipose tissues in patients with obesity. The impact of obesity and weight loss on the expression of specific proteoglycans in adipose tissue is not well known. This study aimed to investigate the relationship between adiposity and proteoglycan expression. We analyzed transcriptomic data from two human bariatric surgery cohorts. In addition, RT-qPCR was performed on adipose tissues from female and male mice fed a high-fat diet. Both visceral and subcutaneous adipose tissue depots were analyzed. Adipose mRNA expression of specific proteoglycans, proteoglycan biosynthetic enzymes, proteoglycan partner molecules, and other ECM-related proteins were altered in both human cohorts. We consistently observed more profound alterations in gene expression of ECM targets in the visceral adipose tissues after surgery (among others VCAN (p = 0.000309), OGN (p = 0.000976), GPC4 (p = 0.00525), COL1A1 (p = 0.00221)). Further, gene analyses in mice revealed sex differences in these two tissue compartments in obese mice. We suggest that adipose tissue repair is still in progress long after surgery, which may reflect challenges in remodeling increased adipose tissues. This study can provide the basis for more mechanistic studies on the role of proteoglycans in adipose tissues in obesity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- extracellular matrix
- proteoglycans
- obesity
- inflammation
- adipose tissue
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Meen, Astri J.
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Doncheva, Atanas ...
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Boettcher, Yvonn ...
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Dankel, Simon N.
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Hoffmann, Anne
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Blueher, Matthia ...
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visa fler...
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Ferno, Johan
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Mellgren, Gunnar
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Ghosh, Adhideb
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Sun, Wenfei
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Dong, Hua
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Noe, Falko
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Wolfrum, Christi ...
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Pejler, Gunnar
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Dalen, Knut Toma ...
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Kolset, Svein O.
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visa färre...
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