European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for digestive neuroendocrine carcinoma

Sorbye, HalfdanHaukeland Hosp, Dept Oncol, Bergen, Norway.;Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Oncol, N-5021 Bergen, Norway. (författare)

This ENETS guidance paper, developed by a multidisciplinary working group, provides up-to-date and practical advice on the diagnosis and management of digestive neuroendocrine carcinoma, based on recent developments and study results. These recommendations aim to pave the road for more standardized care for our patients resulting in improved outcomes. Prognosis is generally poor for digestive NEC, most are advanced at diagnosis and median survival in metastatic disease is 11-12 months. Surgery can be of benefit for localized disease after extensive preoperative imaging. Carboplatin in combination with etoposide is recommended as first-line treatment for metastatic disease. Irinotecan with fluoropyrimidines has the best evidence as second-line treatment. Immunotherapy plays a minor role in biomarker-unselected patients. Molecular profiling if available is encouraged to identify new targets. More prospective clinical trials are highly needed to fulfil the unmet needs in this field, especially on new predictive and prognostic biomarkers and to improve survival of patients with advanced disease.

Grande, EnriqueMD Anderson Canc Ctr Madrid, Dept Med Oncol, Madrid, Spain. (författare)
Pavel, MarianneFriedrich Alexander Univ Erlangen Nurnberg, Dept Med 1, Erlangen, Germany. (författare)
Tesselaar, MargotNetherlands Canc Inst, Dept Gastrointestinal Oncol, Amsterdam, Netherlands. (författare)
Fazio, NicolaEuropean Inst Oncol, Div Gastrointestinal Med Oncol & Neuroendocrine Tu, IEO, IRCCS, Milan, Italy. (författare)
Reed, Nicholas SimonBeatson Oncol Ctr, Dept Clin Oncol, Glasgow City, Scotland. (författare)
Knigge, UlrichCopenhagen Univ Hosp, Rigshospitalet, ENETS Ctr Excellence, Dept Surg & Clin Endocrinol, Copenhagen, Denmark. (författare)
Christ, EmanuelUniv Hosp Basel, ENETS Ctr Excellence, Dept Endocrinol Diabet & Metab, Basel, Switzerland. (författare)
Ambrosini, ValentinaUniv Bologna, Nucl Med, Alma Mater Studiorum, Bologna, Italy.;Azienda Osped Univ Bologna, IRCCS, Bologna, Italy. (författare)
Couvelard, AnneUniv Paris Cite, Bichat Hosp, AP HP, Dept Pathol, Paris, France. (författare)
Tiensuu Janson, EvaUppsala universitet,Onkologisk endokrinologi(Swepub:uu)evatieja (författare)
Haukeland Hosp, Dept Oncol, Bergen, Norway.;Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Oncol, N-5021 Bergen, Norway.MD Anderson Canc Ctr Madrid, Dept Med Oncol, Madrid, Spain. (creator_code:org_t)

Av författaren/redakt...: Sorbye, Halfdan; Grande, Enrique; Pavel, Marianne; Tesselaar, Margo ...; Fazio, Nicola; Reed, Nicholas S ...; visa fler...; Knigge, Ulrich; Christ, Emanuel; Ambrosini, Valen ...; Couvelard, Anne; Tiensuu Janson, ...; visa färre...

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