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Increased plasma en...
Increased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma
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- Hidman, Josefin (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Centrum för klinisk forskning, Västerås
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Thulin, Måns, 1986- (författare)
- Uppsala universitet,Matematiska institutionen
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- Karlsson, Torbjörn (författare)
- Uppsala universitet,Hematologi
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(creator_code:org_t)
- Upsala Medical Society, 2023
- 2023
- Engelska.
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Ingår i: Upsala Journal of Medical Sciences. - : Upsala Medical Society. - 0300-9734 .- 2000-1967. ; 128
- Relaterad länk:
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https://doi.org/10.4...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Increased microvascular density correlates with more advanced disease and unfavorable overall survival in non-Hodgkin lymphoma (NHL), suggesting that angiogenesis is important for disease progression. However, studies of anti-angiogenic agents in NHL patients, have generally not shown favorable outcomes. The aim of this study was to investigate whether plasma levels of a subset of angiogenesis-associated proteins are increased in indolent B-cell derived NHL (B-NHL) and to investigate whether the levels differ between patients with asymptomatic versus symptomatic disease.METHODS: Plasma levels of growth differentiation factor 15 (GDF15), endostatin, matrix metalloproteinase 9 (MMP9), neutrophil gelatinase-associated lipocalin (NGAL), long pentraxin 3 (PTX3), and galectin 3 (GAL-3) were measured by ELISA in 35 patients with symptomatic indolent B-NHL, 41 patients with asymptomatic disease, and 62 healthy controls. Bootstrap t-tests were used to assess the relative differences in biomarker levels between groups. Group differences were visualized using a principal component plot.RESULTS: Mean plasma endostatin and GDF15 levels were significantly higher in symptomatic and asymptomatic lymphoma patients than in controls. Symptomatic patients had higher mean MMP9 and NGAL than controls.CONCLUSIONS: The finding of increased plasma endostatin and GDF15 in patients with asymptomatic indolent B-NHL suggests that increased angiogenic activity is an early event in indolent B-NHL disease progression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Growth differentiation factor 15
- angiogenesis
- endostatin
- matrix metalloproteinase 9
- neutrophil gelatinase-associated lipocalin
- non-Hodgkin lymphoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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