Increased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma

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Hidman, JosefinUppsala universitet,Institutionen för medicinska vetenskaper,Centrum för klinisk forskning, Västerås (author)

Increased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma

Article/chapterEnglish2023

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Upsala Medical Society,2023
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LIBRIS-ID:oai:DiVA.org:uu-502484
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502484URI
https://doi.org/10.48101/ujms.v128.9392DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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BACKGROUND: Increased microvascular density correlates with more advanced disease and unfavorable overall survival in non-Hodgkin lymphoma (NHL), suggesting that angiogenesis is important for disease progression. However, studies of anti-angiogenic agents in NHL patients, have generally not shown favorable outcomes. The aim of this study was to investigate whether plasma levels of a subset of angiogenesis-associated proteins are increased in indolent B-cell derived NHL (B-NHL) and to investigate whether the levels differ between patients with asymptomatic versus symptomatic disease.METHODS: Plasma levels of growth differentiation factor 15 (GDF15), endostatin, matrix metalloproteinase 9 (MMP9), neutrophil gelatinase-associated lipocalin (NGAL), long pentraxin 3 (PTX3), and galectin 3 (GAL-3) were measured by ELISA in 35 patients with symptomatic indolent B-NHL, 41 patients with asymptomatic disease, and 62 healthy controls. Bootstrap t-tests were used to assess the relative differences in biomarker levels between groups. Group differences were visualized using a principal component plot.RESULTS: Mean plasma endostatin and GDF15 levels were significantly higher in symptomatic and asymptomatic lymphoma patients than in controls. Symptomatic patients had higher mean MMP9 and NGAL than controls.CONCLUSIONS: The finding of increased plasma endostatin and GDF15 in patients with asymptomatic indolent B-NHL suggests that increased angiogenic activity is an early event in indolent B-NHL disease progression.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Hematologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Hematology hsv//eng
Growth differentiation factor 15
angiogenesis
endostatin
matrix metalloproteinase 9
neutrophil gelatinase-associated lipocalin
non-Hodgkin lymphoma

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Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andlarss (author)
Thulin, Måns,1986-Uppsala universitet,Matematiska institutionen(Swepub:uu)maner971 (author)
Karlsson, TorbjörnUppsala universitet,Hematologi(Swepub:uu)tokar839 (author)
Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

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In:Upsala Journal of Medical Sciences: Upsala Medical Society1280300-97342000-1967

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