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Development of an E...
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Mak, Jonathan K. L.Karolinska Institutet
(författare)
Development of an Electronic Frailty Index for Hospitalized Older Adults in Sweden
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-03-18
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Oxford University Press,2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-502559
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-502559URI
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https://doi.org/10.1093/gerona/glac069DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149353767URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background Frailty assessment in the Swedish health system relies on the Clinical Frailty Scale (CFS), but it requires training, in-person evaluation, and is often missing in medical records. We aimed to develop an electronic frailty index (eFI) from routinely collected electronic health records (EHRs) and assess its association with adverse outcomes in hospitalized older adults. Methods EHRs were extracted for 18 225 patients with unplanned admissions between 1 March 2020 and 17 June 2021 from 9 geriatric clinics in Stockholm, Sweden. A 48-item eFI was constructed using diagnostic codes, functioning and other health indicators, and laboratory data. The CFS, Hospital Frailty Risk Score, and Charlson Comorbidity Index were used for comparative assessment of the eFI. We modeled in-hospital mortality and 30-day readmission using logistic regression; 30-day and 6-month mortality using Cox regression; and length of stay using linear regression. Results Thirteen thousand one hundred and eighty-eight patients were included in analyses (mean age 83.1 years). A 0.03 increment in the eFI was associated with higher risks of in-hospital (odds ratio: 1.65; 95% confidence interval: 1.54-1.78), 30-day (hazard ratio [HR]: 1.43; 1.38-1.48), and 6-month mortality (HR: 1.34; 1.31-1.37) adjusted for age and sex. Of the frailty and comorbidity measures, the eFI had the highest area under receiver operating characteristic curve for in-hospital mortality of 0.813. Higher eFI was associated with longer length of stay, but had a rather poor discrimination for 30-day readmission. Conclusions An EHR-based eFI has robust associations with adverse outcomes, suggesting that it can be used in risk stratification in hospitalized older adults.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hägg, SaraKarolinska Institutet
(författare)
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Eriksdotter, MariaKarolinska Institutet
(författare)
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Annetorp, MartinKarolinska Institutet
(författare)
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Kuja-Halkola, RalfKarolinska Institutet
(författare)
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Kananen, LauraKarolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden.;Univ Tampere, Fac Social Sci Hlth Sci, Tampere, Finland.;Univ Tampere, Gerontol Res Ctr GEREC, Tampere, Finland.
(författare)
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Boström, Anne-MarieKarolinska Univ Hosp, Theme Inflammat & Aging, Huddinge, Sweden.;Karolinska Inst, Div Nursing, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.;Stockholms Sjukhem, Res & Dev Unit, Stockholm, Sweden.
(författare)
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Kivipelto, MiiaKarolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Karolinska Univ Hosp, Theme Inflammat & Aging, Huddinge, Sweden.
(författare)
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Metzner, CarinaKarolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Karolinska Univ Hosp, Theme Inflammat & Aging, Huddinge, Sweden.
(författare)
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Jerlardtz, Viktoria BäckJakobsbergsgeriatriken, Dept Geriatr Med, Stockholm, Sweden.
(författare)
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Engström, MalinSabbatsbergsgeriatriken, Dept Geriatr Med, Stockholm, Sweden.
(författare)
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Johnson, PeterCapio Geriatr Nacka AB, Dept Geriatr Med, Nacka, Sweden.
(författare)
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Lundberg, Lars GöranDalengeriatriken Aleris Narsjukvard AB, Dept Geriatr Med, Stockholm, Sweden.
(författare)
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Åkesson, ElisabetKarolinska Institutet
(författare)
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Öberg, Carina SühlAleris Narsjukvard AB, Handengeriatriken, Dept Geriatr Med, Stockholm, Sweden.
(författare)
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Olsson, MariaCapio Geriatr Lowet, Dept Geriatr Med, Stockholm, Sweden.;Capio Geriatr Sollentuna, Dept Geriatr Med, Stockholm, Sweden.
(författare)
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Cederholm, TommyUppsala universitet,Klinisk nutrition och metabolism,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden.;Karolinska Univ Hosp, Theme Inflammat & Aging, Huddinge, Sweden.(Swepub:uu)tomce419
(författare)
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Jylhävä, JuuliaKarolinska Institutet
(författare)
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Religa, DorotaKarolinska Institutet
(författare)
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Karolinska InstitutetKarolinska Inst, Dept Med Epidemiol & Biostat, Nobels Vag 12A, S-17177 Stockholm, Sweden.;Univ Tampere, Fac Social Sci Hlth Sci, Tampere, Finland.;Univ Tampere, Gerontol Res Ctr GEREC, Tampere, Finland.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The journals of gerontology. Series A, Biological sciences and medical sciences: Oxford University Press77:11, s. 2311-23191079-50061758-535X
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Mak, Jonathan K. ...
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Hägg, Sara
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Eriksdotter, Mar ...
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Annetorp, Martin
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Kuja-Halkola, Ra ...
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Kananen, Laura
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Kivipelto, Miia
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Metzner, Carina
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Jerlardtz, Vikto ...
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Engström, Malin
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Johnson, Peter
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Lundberg, Lars G ...
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Åkesson, Elisabe ...
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Öberg, Carina Sü ...
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Olsson, Maria
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Cederholm, Tommy
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Jylhävä, Juulia
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Religa, Dorota
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