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Prognostic value of...
Prognostic value of baseline functional status measures and geriatric screening in vulnerable older patients with metastatic colorectal cancer receiving palliative chemotherapy : The randomized NORDIC9-study
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- Liposits, Gabor (författare)
- Odense Univ Hosp, Dept Oncol, Odense, Denmark.;Univ Southern Denmark, Dept Clin Res, Odense, Denmark.;Acad Geriatr Canc Res AgeCare, Odense, Denmark.
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- Ryg, Jesper (författare)
- Univ Southern Denmark, Dept Clin Res, Odense, Denmark.;Acad Geriatr Canc Res AgeCare, Odense, Denmark.;Odense Univ Hosp, Dept Geriatr Med, Odense, Denmark.
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- Skuladottir, Halla (författare)
- Reg Hosp Godstrup, Dept Oncol, Herning, Denmark.
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- Winther, Stine B. (författare)
- Odense Univ Hosp, Dept Oncol, Odense, Denmark.;Acad Geriatr Canc Res AgeCare, Odense, Denmark.
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- Moller, Soren (författare)
- Univ Southern Denmark, Dept Clin Res, Odense, Denmark.;Odense Univ Hosp, OPEN Open Patient data Explorat Network, Odense, Denmark.
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- Hofsli, Eva (författare)
- Trondheim Reg & Univ Hosp, Dept Oncol, Trondheim, Norway.;Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
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- Shah, Carl-Henrik (författare)
- Karolinska Univ Hosp, Theme Canc, Stockholm, Sweden.
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- Poulsen, Laurids ostergaard (författare)
- Aalborg Univ Hosp, Dept Oncol, Aalborg, Denmark.
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Berglund, Åke (författare)
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- Qvortrup, Camilla (författare)
- Acad Geriatr Canc Res AgeCare, Odense, Denmark.
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- Osterlund, Pia (författare)
- Karolinska Institutet,Tampere Univ Hosp, Dept Oncol, Tampere, Finland.;Tampere Univ, Tampere, Finland.;Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Karolinska Inst, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.
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- Glimelius, Bengt (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin
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- Sorbye, Halfdan (författare)
- Haukeland Hosp, Dept Oncol, Bergen, Norway.;Univ Bergen, Dept Clin Sci, Bergen, Norway.
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- Pfeiffer, Per (författare)
- Odense Univ Hosp, Dept Oncol, Odense, Denmark.;Univ Southern Denmark, Dept Clin Res, Odense, Denmark.;Acad Geriatr Canc Res AgeCare, Odense, Denmark.
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Odense Univ Hosp, Dept Oncol, Odense, Denmark;Univ Southern Denmark, Dept Clin Res, Odense, Denmark.;Acad Geriatr Canc Res AgeCare, Odense, Denmark. Univ Southern Denmark, Dept Clin Res, Odense, Denmark.;Acad Geriatr Canc Res AgeCare, Odense, Denmark.;Odense Univ Hosp, Dept Geriatr Med, Odense, Denmark. (creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Journal of Geriatric Oncology. - : Elsevier. - 1879-4068 .- 1879-4076. ; 14:1
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Introduction: Appropriate patient selection based on functional status is crucial when considering older adults for palliative chemotherapy. This pre-planned analysis of the randomized NORDIC9-study explored the prognostic value of four functional status measures regarding progression-free survival (PFS) and overall survival (OS) in vulnerable older patients with metastatic colorectal cancer (mCRC) receiving first-line palliative chemotherapy.Materials and methods: Patients >= 70 years of age with mCRC not candidates for standard full-dose combination chemotherapy were randomized to receive full-dose S1 or reduced-dose S1 + oxaliplatin. At baseline, functional status was assessed using ECOG performance status (ECOG PS), frailty phenotype, Geriatric 8 (G8), and Vulnerable Elderly Survey-13 (VES-13). Multivariable regression models were applied and C-statistics were estimated.Results: In total, 160 patients with a median age of 78 years (IQR: 76-81) were included. While in univariate analyses, ECOG PS, frailty phenotype, and VES-13 were statistically significantly associated with differences in OS between subgroups, G8 was not (HR = 1.55, 95%CI: 0.99-2.41, p = 0.050). In multivariable analyses adjusted for age, sex, body mass index, and treatment allocation, we found significant differences between subgroups for all applied tools and with C-statistics in the moderate range for ECOG PS and VES-13. Concerning PFS, statistically significant differences were observed between subgroups of ECOG PS, G8, and VES-13 both in uni-and multivariable analyses, but not for frailty phenotype.Discussion: In this Nordic cohort of vulnerable older patients with mCRC, baseline ECOG PS, frailty phenotype, G8, and VES-13 showed prognostic value regarding overall survival, and moderate predictive value of models based on ECOG PS and VES-13 was demonstrated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- Survival
- Functional status
- ECOG performance status
- Frailty phenotype
- Geriatric 8
- Vulnerable Elderly Survey-13
- Prognosis
- Colorectal cancer
- Older adults
- Chemotherapy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Liposits, Gabor
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Ryg, Jesper
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Skuladottir, Hal ...
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Winther, Stine B ...
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Moller, Soren
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Hofsli, Eva
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visa fler...
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Shah, Carl-Henri ...
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Poulsen, Laurids ...
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Berglund, Åke
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Qvortrup, Camill ...
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Osterlund, Pia
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Glimelius, Bengt
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Sorbye, Halfdan
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Pfeiffer, Per
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Uppsala universitet
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Karolinska Institutet