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Cerebellar and subc...
Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia
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- Bussy, Aurélie (författare)
- McGill University
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- Levy, Jake P. (författare)
- McConnell Brain Imaging Centre,McGill University
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- Best, Tristin (författare)
- McGill University
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- Patel, Raihaan (författare)
- McGill University
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- Cupo, Lani (författare)
- McGill University
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- Van Langenhove, Tim (författare)
- Ghent University Hospital
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- Nielsen, Jørgen E. (författare)
- Copenhagen University Hospital
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- Pijnenburg, Yolande (författare)
- Vrije Universiteit Amsterdam
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- Waldö, Maria Landqvist (författare)
- Lund University,Lunds universitet,Kliniska Vetenskaper, Helsingborg,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Clinical Sciences, Helsingborg,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Remes, Anne M. (författare)
- Oulu University Hospital,University of Oulu,University of Toronto
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- Schroeter, Matthias L. (författare)
- University Hospital Leipzig
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- Santana, Isabel (författare)
- University Hospital of Coimbra,University of Coimbra
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- Pasquier, Florence (författare)
- Institut Gustave Roussy,University of Lille,Lille University Hospital
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- Otto, Markus (författare)
- University of Ulm
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- Danek, Adrian (författare)
- Ludwig-Maximilian University of Munich
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- Levin, Johannes (författare)
- Ludwig-Maximilian University of Munich,University of Tübingen
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- Le Ber, Isabelle (författare)
- Pitié-Salpêtrière University Hospital,Paris-Sorbonne University
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- Vandenberghe, Rik (författare)
- University Hospitals Leuven
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- Synofzik, Matthis (författare)
- University of Tübingen
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- Moreno, Fermin (författare)
- Biodonostia Health Research Institute,Hospital Universitario Donostia
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- de Mendonça, Alexandre (författare)
- Portuguese National Programme for Respiratory Diseases (PNDR)
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- Sanchez-Valle, Raquel (författare)
- University of Barcelona
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- Laforce, Robert (författare)
- Centre hospitalier universitaire de Québec
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- Langheinrich, Tobias (författare)
- University of Manchester,Salford Royal NHS FoundationTrust
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- Gerhard, Alexander (författare)
- University of Duisburg-Essen,University of Manchester
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- Graff, Caroline (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Butler, Chris R. (författare)
- Imperial College London,University of Oxford
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- Sorbi, Sandro (författare)
- University of Florence,IRCCS Don Gnocchi Foundation
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- Jiskoot, Lize (författare)
- Erasmus University Medical Center
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- Seelaar, Harro (författare)
- Erasmus University Medical Center
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- van Swieten, John C. (författare)
- Erasmus University Medical Center
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- Finger, Elizabeth (författare)
- University of Western Ontario
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Tartaglia, Maria Carmela (författare)
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- Masellis, Mario (författare)
- University of Toronto,McGill University
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- Tiraboschi, Pietro (författare)
- Carlo Besta Neurological Institute, IRCCS
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- Galimberti, Daniela (författare)
- Maggiore Hospital Policlinico,University of Milan
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- Borroni, Barbara (författare)
- University of Brescia,Cambridge University Hospitals NHS Foundation Trust
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- Rowe, James B. (författare)
- Cambridge University Hospitals NHS Foundation Trust
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- Bocchetta, Martina (författare)
- University College London,Brunel University London
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- Rohrer, Jonathan D. (författare)
- Munich Cluster for Systems Neurology
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- Devenyi, Gabriel A. (författare)
- McGill University
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- Chakravarty, M. Mallar (författare)
- McGill University
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- Ducharme, Simon (författare)
- McGill University
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(creator_code:org_t)
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- 2023-03-09
- 2023
- Engelska 17 s.
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Ingår i: Human Brain Mapping. - : Wiley. - 1065-9471 .- 1097-0193. ; 44:7, s. 2684-2700
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Recent studies have reported early cerebellar and subcortical impact in the disease progression of genetic frontotemporal dementia (FTD) due to microtubule-associated protein tau (MAPT), progranulin (GRN) and chromosome 9 open reading frame 72 (C9orf72). However, the cerebello-subcortical circuitry in FTD has been understudied despite its essential role in cognition and behaviors related to FTD symptomatology. The present study aims to investigate the association between cerebellar and subcortical atrophy, and neuropsychiatric symptoms across genetic mutations. Our study included 983 participants from the Genetic Frontotemporal dementia Initiative including mutation carriers and noncarrier first-degree relatives of known symptomatic carriers. Voxel-wise analysis of the thalamus, striatum, globus pallidus, amygdala, and the cerebellum was performed, and partial least squares analyses (PLS) were used to link morphometry and behavior. In presymptomatic C9orf72 expansion carriers, thalamic atrophy was found compared to noncarriers, suggesting the importance of this structure in FTD prodromes. PLS analyses demonstrated that the cerebello-subcortical circuitry is related to neuropsychiatric symptoms, with significant overlap in brain/behavior patterns, but also specificity for each genetic mutation group. The largest differences were in the cerebellar atrophy (larger extent in C9orf72 expansion group) and more prominent amygdalar volume reduction in the MAPT group. Brain scores in the C9orf72 expansion carriers and MAPT carriers demonstrated covariation patterns concordant with atrophy patterns detectable up to 20 years before expected symptom onset. Overall, these results demonstrated the important role of the subcortical structures in genetic FTD symptom expression, particularly the cerebellum in C9orf72 and the amygdala in MAPT carriers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- frontotemporal dementia
- genetics
- magnetic resonance imaging
- neuropsychiatry
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- art (ämneskategori)
- ref (ämneskategori)
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Bussy, Aurélie
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Levy, Jake P.
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Best, Tristin
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Patel, Raihaan
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Cupo, Lani
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Van Langenhove, ...
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visa fler...
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Nielsen, Jørgen ...
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Pijnenburg, Yola ...
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Waldö, Maria Lan ...
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Remes, Anne M.
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Schroeter, Matth ...
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Santana, Isabel
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Pasquier, Floren ...
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Otto, Markus
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Danek, Adrian
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Levin, Johannes
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Le Ber, Isabelle
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Vandenberghe, Ri ...
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Synofzik, Matthi ...
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Moreno, Fermin
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de Mendonça, Ale ...
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Sanchez-Valle, R ...
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Laforce, Robert
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Langheinrich, To ...
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Gerhard, Alexand ...
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Graff, Caroline
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Butler, Chris R.
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Sorbi, Sandro
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Jiskoot, Lize
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Seelaar, Harro
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van Swieten, Joh ...
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Finger, Elizabet ...
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Tartaglia, Maria ...
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Masellis, Mario
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Tiraboschi, Piet ...
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Galimberti, Dani ...
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Borroni, Barbara
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Rowe, James B.
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Bocchetta, Marti ...
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Rohrer, Jonathan ...
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Devenyi, Gabriel ...
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Chakravarty, M. ...
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Ducharme, Simon
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Neurovetenskaper
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Lunds universitet
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Karolinska Institutet