The next wave of interactomics: Mapping the SLiM-based interactions of the intrinsically disordered proteome

Davey, Norman E.Inst Canc Res, Div Canc Biol, 237 Fulham Rd, London SW3 6JB, England. (author)

The next wave of interactomics : Mapping the SLiM-based interactions of the intrinsically disordered proteome

Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules that perform key regulatory functions and drive dynamic complex formation. For decades, interactions mediated by SLiMs have accumulated through detailed low-throughput experiments. Recent methodological advances have opened this previously underexplored area of the human interactome to high-throughput protein-protein interaction discovery. In this article, we discuss that SLiM-based interactions represent a significant blind spot in the current interactomics data, introduce the key methods that are illuminating the elusive SLiM-mediated interactome of the human cell on a large scale, and discuss the implications for the field.

NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
Short linear motifs (SLiMs)
Protein-protein interactions
Interactomics
High-throughput methods
Protein-peptide interactions

Simonetti, LeandroUppsala universitet,Biokemi(Swepub:uu)leasi418 (author)
Ivarsson, YlvaUppsala universitet,Biokemi(Swepub:uu)yliva676 (author)
Inst Canc Res, Div Canc Biol, 237 Fulham Rd, London SW3 6JB, England.Biokemi (creator_code:org_t)

By the author/editor: Davey, Norman E.; Simonetti, Leand ...; Ivarsson, Ylva

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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