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  • Boccalini, CeciliaUniv Geneva, Geneva Univ, Neuroctr, Lab Neuroimaging & Innovat Mol Tracers NIMTlab, Geneva, Switzerland.;Univ Geneva, Fac Med, Geneva, Switzerland.;Univ Vita Salute San Raffaele, Milan, Italy.;IRCCS, San Raffaele Sci Inst, Div Neurosci, In Vivo Human Mol & Struct Neuroimaging Unit, Milan, Italy. (författare)

Early-Phase 18F-Florbetapir and 18F-Flutemetamol Images as Proxies of Brain Metabolism in a Memory Clinic Setting

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2022-07-21
  • The Society of Nuclear Medicine and Molecular Imaging,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-503657
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-503657URI
  • https://doi.org/10.2967/jnumed.122.264256DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Alzheimer disease (AD) neuropathologic changes are 6-amyloid (A6) deposition, pathologic tau, and neurodegeneration. Dual-phase amy-loid PET might be able to evaluate A6 deposition and neurodegenera-tion with a single tracer injection. Early-phase amyloid PET scans provide a proxy for cerebral perfusion, which has shown good correla-tions with neural dysfunction measured through metabolic consump-tion, whereas the late frames depict amyloid distribution. Our study aimed to assess the comparability between early-phase amyloid PET scans and 18F-FDG PET brain topography at the individual level and their ability to discriminate patients. Methods: One hundred sixty-six subjects evaluated at the Geneva Memory Center, ranging from no cognitive impairment to mild cognitive impairment and dementia, underwent early-phase amyloid PET-using either 18F-florbetapir (eFBP) (n = 94) or 18F-flutemetamol (eFMM) (n = 72)-and 18F-FDG PET. A6 status was assessed. SUV ratios (SUVRs) were extracted to evaluate the correlation of eFBP/eFMM and their respective 18F-FDG PET scans. The single-subject procedure was applied to investigate hypometabolism and hypoperfusion maps and their spatial overlap by the Dice coefficient. Receiver-operating-characteristic analyses were performed to compare the discriminative power of eFBP/eFMM and 18F-FDG PET SUVR in AD-related meta-regions of interest between A6-negative healthy controls and cases in the AD continuum. Results: Positive correlations were found between eFBP/eFMM and 18F-FDG PET SUVR independently of A6 status and A6 radiotracer (R> 0.72, P< 0.001). eFBP/eFMM single-subject analysis revealed clusters of significant hypoperfusion with good correspondence to hypometabo-lism topographies, independently of the underlying neurodegenerative patterns. Both eFBP/eFMM and 18F-FDG PET SUVR significantly dis-criminated AD patients from controls in the AD-related meta-regions of interest (eFBP area under the curve [AUC], 0.888; eFMM AUC, 0.801), with 18F-FDG PET performing slightly better, although not sig-nificantly (all P values higher than 0.05), than others (18F-FDG AUC, 0.915 and 0.832 for subjects evaluated with eFBP and eFMM, respec-tively). Conclusion: The distribution of perfusion was comparable to that of metabolism at the single-subject level by parametric analysis, particularly in the presence of a high neurodegeneration burden. Our findings indicate that eFBP and eFMM imaging can replace 18F-FDG PET imaging, as they reveal typical neurodegenerative patterns or allow exclusion of the presence of neurodegeneration. The findings show cost-saving capacities of amyloid PET and support routine use of the modality for individual classification in clinical practice.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Peretti, Debora ElisaUniv Geneva, Geneva Univ, Neuroctr, Lab Neuroimaging & Innovat Mol Tracers NIMTlab, Geneva, Switzerland.;Univ Geneva, Fac Med, Geneva, Switzerland. (författare)
  • Ribaldi, FedericaUniv Geneva, Lab Neuroimaging Aging LANVIE, Geneva, Switzerland.;Geneva Univ Hosp, Memory Clin, Geneva, Switzerland. (författare)
  • Scheffler, MaxGeneva Univ Hosp, Diagnost Dept, Div Radiol, Geneva, Switzerland. (författare)
  • Stampacchia, SaraUniv Geneva, Geneva Univ, Neuroctr, Lab Neuroimaging & Innovat Mol Tracers NIMTlab, Geneva, Switzerland.;Univ Geneva, Fac Med, Geneva, Switzerland. (författare)
  • Tomczyk, SzymonUniv Geneva, Lab Neuroimaging Aging LANVIE, Geneva, Switzerland. (författare)
  • Rodriguez, CristelleUniv Hosp Geneva, Div Inst Measures, Med Direct, Geneva, Switzerland.;Univ Geneva, Fac Med, Dept Psychiat, Geneva, Switzerland. (författare)
  • Montandon, Marie-LouiseUniv Geneva, Fac Med, Dept Psychiat, Geneva, Switzerland.;Geneva Univ Hosp, Dept Rehabil & Geriatr, Geneva, Switzerland.;Univ Geneva, Geneva, Switzerland. (författare)
  • Haller, SvenUppsala universitet,Radiologi,CIMC Ctr Imagerie Med Cornavin, Geneva, Switzerland.;Univ Geneva, Fac Med, Geneva, Switzerland.;Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing, Peoples R China.(Swepub:uu)sveha228 (författare)
  • Giannakopoulos, PanteleimonUniv Hosp Geneva, Div Inst Measures, Med Direct, Geneva, Switzerland.;Univ Geneva, Fac Med, Dept Psychiat, Geneva, Switzerland. (författare)
  • Frisoni, Giovanni B.Univ Geneva, Lab Neuroimaging Aging LANVIE, Geneva, Switzerland.;Geneva Univ Hosp, Memory Clin, Geneva, Switzerland. (författare)
  • Perani, DanielaUniv Vita Salute San Raffaele, Milan, Italy.;IRCCS, San Raffaele Sci Inst, Div Neurosci, In Vivo Human Mol & Struct Neuroimaging Unit, Milan, Italy.;Osped San Raffaele, Nucl Med Unit, Milan, Italy. (författare)
  • Garibotto, ValentinaUniv Geneva, Geneva Univ, Neuroctr, Lab Neuroimaging & Innovat Mol Tracers NIMTlab, Geneva, Switzerland.;Univ Geneva, Fac Med, Geneva, Switzerland.;Geneva Univ Hosp, Div Nucl Med & Mol Imaging, Geneva, Switzerland.;CIBM Ctr Biomed Imaging, Geneva, Switzerland. (författare)
  • Univ Geneva, Geneva Univ, Neuroctr, Lab Neuroimaging & Innovat Mol Tracers NIMTlab, Geneva, Switzerland.;Univ Geneva, Fac Med, Geneva, Switzerland.;Univ Vita Salute San Raffaele, Milan, Italy.;IRCCS, San Raffaele Sci Inst, Div Neurosci, In Vivo Human Mol & Struct Neuroimaging Unit, Milan, Italy.Univ Geneva, Geneva Univ, Neuroctr, Lab Neuroimaging & Innovat Mol Tracers NIMTlab, Geneva, Switzerland.;Univ Geneva, Fac Med, Geneva, Switzerland. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Nuclear Medicine: The Society of Nuclear Medicine and Molecular Imaging64:2, s. 266-2730161-55051535-56672159-662X

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