Micro Germline-Restricted Chromosome in Blue Tits: Evidence for Meiotic Functions

Mueller, Jakob C.Max Planck Inst Biol Intelligence, Dept Behav Ecol & Evolutionary Genet, Seewiesen, Germany. (författare)

Micro Germline-Restricted Chromosome in Blue Tits : Evidence for Meiotic Functions

The germline-restricted chromosome (GRC) is likely present in all songbird species but differs widely in size and gene content. This extra chromosome has been described as either a microchromosome with only limited basic gene content or a macrochromosome with enriched gene functions related to female gonad and embryo development. Here, we assembled, annotated, and characterized the first micro-GRC in the blue tit (Cyanistes caeruleus) using high-fidelity long-read sequencing data. Although some genes on the blue tit GRC show signals of pseudogenization, others potentially have important functions, either currently or in the past. We highlight the GRC gene paralog BMP15, which is among the highest expressed GRC genes both in blue tits and in zebra finches (Taeniopygia guttata) and is known to play a role in oocyte and follicular maturation in other vertebrates. The GRC genes of the blue tit are further enriched for functions related to the synaptonemal complex. We found a similar functional enrichment when analyzing published data on GRC genes from two nightingale species (Luscinia spp.). We hypothesize that these genes play a role in maintaining standard maternal inheritance or in recombining maternal and paternal GRCs during potential episodes of biparental inheritance.

Schlebusch, Stephen A.Charles Univ Prague, Dept Zool, Prague, Czech Republic. (författare)
Pei, YifanMax Planck Inst Biol Intelligence, Dept Behav Ecol & Evolutionary Genet, Seewiesen, Germany. (författare)
Poignet, ManonCharles Univ Prague, Dept Zool, Prague, Czech Republic. (författare)
Vontzou, NikiUniv East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich, England. (författare)
Ruiz-Ruano, Francisco J.Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich, England. (författare)
Albrecht, TomasCharles Univ Prague, Dept Zool, Prague, Czech Republic.;Acad Sci, Inst Vertebrate Biol, Brno, Czech Republic. (författare)
Reifova, RadkaCharles Univ Prague, Dept Zool, Prague, Czech Republic. (författare)
Forstmeier, WolfgangMax Planck Inst Biol Intelligence, Dept Behav Ecol & Evolutionary Genet, Seewiesen, Germany. (författare)
Suh, AlexanderUppsala universitet,Science for Life Laboratory, SciLifeLab,Systematisk biologi,Univ East Anglia, Sch Biol Sci, Norwich Res Pk, Norwich, England.(Swepub:uu)alesu519 (författare)
Kempenaers, BartMax Planck Inst Biol Intelligence, Dept Behav Ecol & Evolutionary Genet, Seewiesen, Germany. (författare)
Max Planck Inst Biol Intelligence, Dept Behav Ecol & Evolutionary Genet, Seewiesen, Germany.Charles Univ Prague, Dept Zool, Prague, Czech Republic. (creator_code:org_t)

Ingår i:Molecular biology and evolution: Oxford University Press40:50737-40381537-1719

Av författaren/redakt...: Mueller, Jakob C ...; Schlebusch, Step ...; Pei, Yifan; Poignet, Manon; Vontzou, Niki; Ruiz-Ruano, Fran ...; visa fler...; Albrecht, Tomas; Reifova, Radka; Forstmeier, Wolf ...; Suh, Alexander; Kempenaers, Bart; visa färre...

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