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Plasma protein changes reflect colorectal cancer development and associated inflammation

Urbiola-Salvador, Victor (author)
Univ Gdansk, Intercollegiate Fac Biotechnol, Gdansk, Poland.;Univ Gdansk, Med Univ Gdansk, Gdansk, Poland.
Jablonska, Agnieszka (author)
Univ Gdansk, Intercollegiate Fac Biotechnol, Gdansk, Poland.;Univ Gdansk, Med Univ Gdansk, Gdansk, Poland.
Miroszewska, Dominika (author)
Univ Gdansk, Intercollegiate Fac Biotechnol, Gdansk, Poland.;Univ Gdansk, Med Univ Gdansk, Gdansk, Poland.
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Huang, Qianru (author)
Shanghai Jiao Tong Univ, Sch Med, Ctr Immune Related Dis, Shanghai Inst Immunol,Dept Resp & Crit Care Med,Ru, Shanghai, Peoples R China.
Duzowska, Katarzyna (author)
Med Univ Gdansk, 3P Med Lab, Gdansk, Poland.
Drezek-Chyla, Kinga (author)
Med Univ Gdansk, 3P Med Lab, Gdansk, Poland.
Zdrenka, Marek (author)
Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Poland.
Srutek, Ewa (author)
Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Poland.
Szylberg, Lukasz (author)
Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Tumor Pathol & Pathomorphol, Bydgoszcz, Poland.;Nicolaus Copernicus Univ Torun, Dept Obstet Gynaecol & Oncol, Coll Med Bydgoszcz, Bydgoszcz, Poland.
Jankowski, Michal (author)
Nicolaus Copernicus Univ Torun, Ludwik Rydygiers Coll Med Bydgoszcz, Surg Oncol, Ludwik Rydygiers Coll Med Bydgoszcz,Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Poland.
Bala, Dariusz (author)
Nicolaus Copernicus Univ Torun, Ludwik Rydygiers Coll Med Bydgoszcz, Surg Oncol, Ludwik Rydygiers Coll Med Bydgoszcz,Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Poland.
Zegarski, Wojciech (author)
Nicolaus Copernicus Univ Torun, Ludwik Rydygiers Coll Med Bydgoszcz, Surg Oncol, Ludwik Rydygiers Coll Med Bydgoszcz,Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Surg Oncol, Bydgoszcz, Poland.
Nowikiewicz, Tomasz (author)
Nicolaus Copernicus Univ Torun, Ludwik Rydygiers Coll Med Bydgoszcz, Surg Oncol, Ludwik Rydygiers Coll Med Bydgoszcz,Surg Oncol, Torun, Poland.;Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Dept Breast Canc & Reconstruct Surg, Bydgoszcz, Poland.
Makarewicz, Wojciech (author)
Specialist Hosp Koscierzyna, Clin Gen & Oncol Surg, Koscierzyna, Poland. Maria Sklodowska Curie Natl Res Inst Oncol, Dept Tumor Pathol, Krakow, Poland.
Adamczyk, Agnieszka (author)
Ambicka, Aleksandra (author)
Przewoznik, Marcin (author)
Harazin-Lechowicz, Agnieszka (author)
Rys, Janusz (author)
Filipowicz, Natalia (author)
Med Univ Gdansk, 3P Med Lab, Gdansk, Poland.
Piotrowski, Arkadiusz (author)
Med Univ Gdansk, 3P Med Lab, Gdansk, Poland.
Dumanski, Jan P. (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi,Med Univ Gdansk, 3P Med Lab, Gdansk, Poland.;Med Univ Gdansk, Dept Biol & Pharmaceut Bot, Gdansk, Poland.
Li, Bin (author)
Shanghai Jiao Tong Univ, Sch Med, Ctr Immune Related Dis, Shanghai Inst Immunol,Dept Resp & Crit Care Med,Ru, Shanghai, Peoples R China.
Chen, Zhi (author)
Univ Gdansk, Intercollegiate Fac Biotechnol, Gdansk, Poland.;Univ Gdansk, Med Univ Gdansk, Gdansk, Poland.;Univ Oulu, Fac Biochem & Mol Med, Oulu, Finland.
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Univ Gdansk, Intercollegiate Fac Biotechnol, Gdansk, Poland;Univ Gdansk, Med Univ Gdansk, Gdansk, Poland. Shanghai Jiao Tong Univ, Sch Med, Ctr Immune Related Dis, Shanghai Inst Immunol,Dept Resp & Crit Care Med,Ru, Shanghai, Peoples R China. (creator_code:org_t)
Frontiers Media S.A. 2023
2023
English.
In: Frontiers in Oncology. - : Frontiers Media S.A.. - 2234-943X. ; 13
Related links:
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Introduction: Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of death worldwide. Efficient non-invasive blood-based biomarkers for CRC early detection and prognosis are urgently needed.Methods: To identify novel potential plasma biomarkers, we applied a proximity extension assay (PEA), an antibody-based proteomics strategy to quantify the abundance of plasma proteins in CRC development and cancer-associated inflammation from few mu L of plasma sample.Results: Among the 690 quantified proteins, levels of 202 plasma proteins were significantly changed in CRC patients compared to age-and-sex-matched healthy subjects. We identified novel protein changes involved in Th17 activity, oncogenic pathways, and cancer-related inflammation with potential implications in the CRC diagnosis. Moreover, the interferon gamma (IFNG), interleukin (IL) 32, and IL17C were identified as associated with the early stages of CRC, whereas lysophosphatidic acid phosphatase type 6 (ACP6), Fms-related tyrosine kinase 4 (FLT4), and MANSC domain-containing protein 1 (MANSC1) were correlated with the late-stages of CRC.Discussion: Further study to characterize the newly identified plasma protein changes from larger cohorts will facilitate the identification of potential novel diagnostic, prognostic biomarkers for CRC.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

biomarker
colorectal cancer
plasma proteomics
proximity extension assay
inflammation
early detection
cytokines
prognosis

Publication and Content Type

ref (subject category)
art (subject category)

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