Sökning: WFRF:(Löhr J Matthias)
> (2023) >
Chemoselective bicy...
Chemoselective bicyclobutane-based mass spectrometric detection of biological thiols uncovers human and bacterial metabolites
-
- Kaur, Amanpreet (författare)
- Uppsala universitet,Institutionen för kemi - BMC,Science for Life Laboratory, SciLifeLab
-
- Lin, Weifeng (författare)
- Uppsala universitet,Analytisk kemi,Kemisk biologi för biomarkörer,Science for Life Laboratory, SciLifeLab
-
- Dovhalyuk, Vladyslav (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för kemi - BMC
-
visa fler...
-
- Driutti, Léna (författare)
- Uppsala universitet,Institutionen för kemi - BMC,Science for Life Laboratory, SciLifeLab
-
- Di Martino, Maria Letizia (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
-
- Vujasinovic, Miroslav (författare)
- Department for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden
-
- Löhr, J.-Matthias (författare)
- Karolinska Institutet,Department for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden;Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institute, Stockholm, Sweden
-
- Sellin, Mikael E. (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi
-
- Globisch, Daniel (författare)
- Uppsala universitet,Kemisk biologi för biomarkörer,Science for Life Laboratory, SciLifeLab,Analytisk kemi
-
visa färre...
-
(creator_code:org_t)
- Royal Society of Chemistry, 2023
- 2023
- Engelska.
-
Ingår i: Chemical Science. - : Royal Society of Chemistry. - 2041-6520 .- 2041-6539. ; 14:20, s. 5291-5301
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Sulfur is an essential element of life. Thiol-containing metabolites in all organisms are involved in the regulation of diverse biological processes. Especially, the microbiome produces bioactive metabolites or biological intermediates of this compound class. The analysis of thiol-containing metabolites is challenging due to the lack of specific tools, making these compounds difficult to investigate selectively. We have now developed a new methodology comprising bicyclobutane for chemoselective and irreversible capturing of this metabolite class. We utilized this new chemical biology tool immobilized onto magnetic beads for the investigation of human plasma, fecal samples, and bacterial cultures. Our mass spectrometric investigation detected a broad range of human, dietary and bacterial thiol-containing metabolites and we even captured the reactive sulfur species cysteine persulfide in both fecal and bacterial samples. The described comprehensive methodology represents a new mass spectrometric strategy for the discovery of bioactive thiol-containing metabolites in humans and the microbiome.
Ämnesord
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi -- Annan kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Other Chemistry Topics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
- kfu (ämneskategori)
Hitta via bibliotek
Till lärosätets databas