The Role of Macula Densa Nitric Oxide Synthase 1 Beta Splice Variant in Modulating Tubuloglomerular Feedback

Liu, RuishengUniv S Florida, Morsani Coll Med, Dept Mol Pharmacol & Physiol, Tampa, FL 33620 USA.;Univ S Florida, Morsani Coll Med, Hypertens & Kidney Res Ctr, Tampa, FL 33620 USA. (författare)

Abnormalities in renal electrolyte and water excretion may result in inappropriate salt and water retention, which facilitates the development and maintenance of hypertension, as well as acid-base and electrolyte disorders. A key mechanism by which the kidney regulates renal hemodynamics and electrolyte excretion is via tubuloglomerular feedback (TGF), an intrarenal negative feedback between tubules and arterioles. TGF is initiated by an increase of NaCl delivery at the macula densa cells. The increased NaCl activates luminal Na-K-2Cl cotransporter (NKCC2) of the macula densa cells, which leads to activation of several intracellular processes followed by the production of paracrine signals that ultimately result in a constriction of the afferent arteriole and a tonic inhibition of single nephron glomerular filtration rate. Neuronal nitric oxide (NOS1) is highly expressed in the macula densa. NOS1 beta is the major splice variant and accounts for most of NO generation by the macula densa, which inhibits TGF response. Macula densa NOS1 beta-mediated modulation of TGF responses plays an essential role in control of sodium excretion, volume and electrolyte hemostasis, and blood pressure. In this article, we describe the mechanisms that regulate macula densa-derived NO and their effect on TGF response in physiologic and pathologic conditions. (c) 2023 American Physiological Society.

Juncos, Luis A.Cent Arkansas Vet Healthcare Syst, Dept Internal Med, Little Rock, AR USA. (författare)
Lu, YanUniv Alabama Birmingham, Div Nephrol, Birmingham, AL USA. (författare)
Wei, JinUniv S Florida, Morsani Coll Med, Dept Mol Pharmacol & Physiol, Tampa, FL 33620 USA. (författare)
Zhang, JieUniv S Florida, Morsani Coll Med, Dept Mol Pharmacol & Physiol, Tampa, FL 33620 USA. (författare)
Wang, LeiUniv S Florida, Morsani Coll Med, Dept Mol Pharmacol & Physiol, Tampa, FL 33620 USA. (författare)
Lai, En Y.Zhejiang Univ, Sch Basic Med Sci, Sch Med, Dept Physiol, Hangzhou, Peoples R China. (författare)
Carlstrom, MattiasKarolinska Institutet (författare)
Persson, ErikUppsala universitet,Integrativ Fysiologi(Swepub:uu)erikpers (författare)
Univ S Florida, Morsani Coll Med, Dept Mol Pharmacol & Physiol, Tampa, FL 33620 USA.;Univ S Florida, Morsani Coll Med, Hypertens & Kidney Res Ctr, Tampa, FL 33620 USA.Cent Arkansas Vet Healthcare Syst, Dept Internal Med, Little Rock, AR USA. (creator_code:org_t)

Av författaren/redakt...: Liu, Ruisheng; Juncos, Luis A.; Lu, Yan; Wei, Jin; Zhang, Jie; Wang, Lei; visa fler...; Lai, En Y.; Carlstrom, Matti ...; Persson, Erik; visa färre...

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