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- Rask-Andersen, Mathias,1979-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi (author)
Adiposity and sex-specific cancer risk.
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- 2023
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-505445
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-505445URI
- https://doi.org/10.1016/j.ccell.2023.05.010DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Obesity is associated with several types of cancer and fat distribution, which differs dramatically between sexes, has been suggested to be an independent risk factor. However, sex-specific effects on cancer risk have rarely been studied. Here we estimate the effects of fat accumulation and distribution on cancer risk in females and males. We performed a prospective study in 442,519 UK Biobank participants, for 19 cancer types and additional histological subtypes, with a mean follow-up time of 13.4 years. Cox proportional hazard models were used to estimate the effect of 14 different adiposity phenotypes on cancer rates, and a 5% false discovery rate was considered statistically significant. Adiposity-related traits are associated with all but three cancer types, and fat accumulation is associated with a larger number of cancers compared to fat distribution. In addition, fat accumulation or distribution exhibit differential effects between sexes on colorectal, esophageal, and liver cancer.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Medicinsk genetik hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Medical Genetics hsv//eng
- BMI
- UK Biobank
- WHRadjBMI
- body fat distribution
- cancer
- cox proportional hazard modeling
- obesity
- risk factors
- sex-interactions
Added entries (persons, corporate bodies, meetings, titles ...)
- Ivansson, EmmaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)emfra062 (author)
- Höglund, JuliaUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)julho506 (author)
- Ek, Weronica E.Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)werek336 (author)
- Karlsson, TorgnyUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi(Swepub:uu)tka28508 (author)
- Johansson, ÅsaUppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)asjoh108 (author)
- Uppsala universitetScience for Life Laboratory, SciLifeLab (creator_code:org_t)
Related titles
- In:Cancer Cell41:6, s. 1186-1197.e41535-61081878-3686
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