Search: (WFRF:(Lindström Sandra A. M.)) >
Genome-wide associa...
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Williamson, AliceUniversity of Cambridge
(author)
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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Springer Nature,2023
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-505815
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-505815URI
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https://doi.org/10.1038/s41588-023-01408-9DOI
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https://lup.lub.lu.se/record/6adcc06f-a8d0-4413-9604-f244c2628fdcURI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10-8) not previously associated with postchallenge insulin resistance, eight of which were shown to share their genetic architecture with type 2 diabetes in colocalization analyses. We investigated candidate genes at a subset of associated loci in cultured cells and identified nine candidate genes newly implicated in the expression or trafficking of GLUT4, the key glucose transporter in postprandial glucose uptake in muscle and fat. By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Norris, Dougall M
(author)
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Yin, Xianyong
(author)
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Broadaway, K Alaine
(author)
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Moxley, Anne H
(author)
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Vadlamudi, Swarooparani
(author)
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Wilson, Emma P
(author)
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Jackson, Anne U
(author)
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Ahuja, Vasudha
(author)
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Andersen, Mette K
(author)
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Arzumanyan, Zorayr
(author)
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Bonnycastle, Lori L
(author)
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Bornstein, Stefan R
(author)
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Bretschneider, Maxi P
(author)
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Buchanan, Thomas A
(author)
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Chang, Yi-Cheng
(author)
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Chuang, Lee-Ming
(author)
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Chung, Ren-Hua
(author)
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Clausen, Tine D
(author)
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Damm, Peter
(author)
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Delgado, Graciela E
(author)
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de Mello, Vanessa D
(author)
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Dupuis, Josée
(author)
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Dwivedi, Om P
(author)
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Erdos, Michael R
(author)
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Silva, Lilian Fernandes
(author)
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Frayling, Timothy M
(author)
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Gieger, Christian
(author)
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Goodarzi, Mark O
(author)
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Guo, Xiuqing
(author)
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Gustafsson, StefanUppsala universitet,Klinisk epidemiologi(Swepub:uu)stegu732
(author)
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Hakaste, Liisa
(author)
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Hammar, UlfUppsala universitet,Molekylär epidemiologi(Swepub:uu)ulfha881
(author)
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Hatem, G.Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)ga5503ha
(author)
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Herrmann, Sandra
(author)
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Højlund, Kurt
(author)
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Horn, Katrin
(author)
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Hsueh, Willa A
(author)
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Hung, Yi-Jen
(author)
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Hwu, Chii-Min
(author)
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Jonsson, Anna
(author)
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Kårhus, Line L
(author)
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Kleber, Marcus E
(author)
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Kovacs, Peter
(author)
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Lakka, Timo A
(author)
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Lauzon, Marie
(author)
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Lee, I-Te
(author)
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Lindgren, Cecilia M
(author)
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Lindström, Jaana
(author)
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Linneberg, Allan
(author)
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Liu, Ching-Ti
(author)
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Luan, Jian'an
(author)
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Aly, D.M.Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)di3053ma
(author)
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Mathiesen, Elisabeth
(author)
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Moissl, Angela P
(author)
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Morris, Andrew P
(author)
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Narisu, Narisu
(author)
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Perakakis, Nikolaos
(author)
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Peters, Annette
(author)
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Prasad, R.B.Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki(Swepub:lu)med-rpa
(author)
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Rodionov, Roman N
(author)
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Roll, Kathryn
(author)
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Rundsten, Carsten F
(author)
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Sarnowski, Chloé
(author)
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Savonen, Kai
(author)
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Scholz, Markus
(author)
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Sharma, Sapna
(author)
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Stinson, Sara E
(author)
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Suleman, Sufyan
(author)
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Tan, Jingyi
(author)
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Taylor, Kent D
(author)
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Uusitupa, Matti
(author)
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Vistisen, Dorte
(author)
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Witte, Daniel R
(author)
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Walther, Romy
(author)
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Wu, Peitao
(author)
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Xiang, Anny H
(author)
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Zethelius, BjörnUppsala universitet,Geriatrik(Swepub:uu)bjorzeth
(author)
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Ahlqvist, E.Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)infl-eah
(author)
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Bergman, Richard N
(author)
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Chen, Yii-Der Ida
(author)
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Collins, Francis S
(author)
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Fall, Tove,1979-Uppsala universitet,Molekylär epidemiologi(Swepub:uu)tovfa878
(author)
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Florez, Jose C
(author)
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Fritsche, Andreas
(author)
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Grallert, Harald
(author)
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Groop, L.Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki(Swepub:lu)endo-lgr
(author)
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Hansen, Torben
(author)
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Koistinen, Heikki A
(author)
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Komulainen, Pirjo
(author)
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Laakso, Markku
(author)
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Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind
(author)
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Loeffler, Markus
(author)
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März, Winfried
(author)
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Meigs, James BLund University,University Hospital of Tubingen,Massachusetts General Hospital
(author)
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Raffel, Leslie J
(author)
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Rauramaa, Rainer
(author)
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Rotter, Jerome I
(author)
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Schwarz, Peter E H
(author)
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Stumvoll, Michael
(author)
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Sundström, Johan,Professor,1971-Uppsala universitet,Klinisk epidemiologi(Swepub:uu)johasund
(author)
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Tönjes, Anke
(author)
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Tuomi, Tiinamaija
(author)
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Tuomilehto, Jaakko
(author)
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Wagner, Robert
(author)
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Barroso, Inês
(author)
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Walker, Mark
(author)
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Grarup, Niels
(author)
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Boehnke, Michael
(author)
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Wareham, Nicholas J
(author)
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Mohlke, Karen L
(author)
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Wheeler, Eleanor
(author)
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O'Rahilly, Stephen
(author)
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Fazakerley, Daniel J
(author)
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Langenberg, ClaudiaQueen Mary University,University of Cambridge,Berlin Institute of Health (BIH),Charité - University Medicine Berlin
(author)
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University of CambridgeKlinisk epidemiologi
(creator_code:org_t)
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et al.
Related titles
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In:Nature Genetics: Springer Nature55:6, s. 973-9831061-40361546-1718
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Williamson, Alic ...
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Norris, Dougall ...
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Yin, Xianyong
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Broadaway, K Ala ...
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Moxley, Anne H
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Vadlamudi, Swaro ...
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Wilson, Emma P
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Ahuja, Vasudha
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Andersen, Mette ...
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Arzumanyan, Zora ...
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Bonnycastle, Lor ...
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Bornstein, Stefa ...
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Bretschneider, M ...
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Chang, Yi-Cheng
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Clausen, Tine D
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de Mello, Vaness ...
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Dupuis, Josée
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Silva, Lilian Fe ...
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Frayling, Timoth ...
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Goodarzi, Mark O
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Guo, Xiuqing
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Hammar, Ulf
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Hatem, G.
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Herrmann, Sandra
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Højlund, Kurt
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Horn, Katrin
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Hsueh, Willa A
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Hung, Yi-Jen
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Hwu, Chii-Min
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Jonsson, Anna
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Kårhus, Line L
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Kleber, Marcus E
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Kovacs, Peter
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Lakka, Timo A
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Lauzon, Marie
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Lee, I-Te
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Lindgren, Cecili ...
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Lindström, Jaana
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Linneberg, Allan
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Liu, Ching-Ti
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Luan, Jian'an
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Aly, D.M.
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Mathiesen, Elisa ...
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Moissl, Angela P
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Morris, Andrew P
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Narisu, Narisu
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Perakakis, Nikol ...
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Peters, Annette
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Prasad, R.B.
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Rodionov, Roman ...
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Roll, Kathryn
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Rundsten, Carste ...
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Sarnowski, Chloé
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Savonen, Kai
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Scholz, Markus
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Sharma, Sapna
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Stinson, Sara E
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Suleman, Sufyan
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Tan, Jingyi
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Taylor, Kent D
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Uusitupa, Matti
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Vistisen, Dorte
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Witte, Daniel R
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Walther, Romy
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Wu, Peitao
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Xiang, Anny H
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Zethelius, Björn
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Ahlqvist, E.
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Bergman, Richard ...
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Chen, Yii-Der Id ...
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Collins, Francis ...
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Fall, Tove, 1979 ...
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Florez, Jose C
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Fritsche, Andrea ...
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Grallert, Harald
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Groop, L.
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Hansen, Torben
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Koistinen, Heikk ...
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Komulainen, Pirj ...
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Laakso, Markku
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Lind, Lars
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Loeffler, Markus
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März, Winfried
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Meigs, James B
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Raffel, Leslie J
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Rauramaa, Rainer
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Rotter, Jerome I
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Schwarz, Peter E ...
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Stumvoll, Michae ...
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Sundström, Johan ...
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Tönjes, Anke
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Tuomi, Tiinamaij ...
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Tuomilehto, Jaak ...
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Wagner, Robert
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Barroso, Inês
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Walker, Mark
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Grarup, Niels
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Boehnke, Michael
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Wareham, Nichola ...
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Mohlke, Karen L
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Wheeler, Eleanor
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O'Rahilly, Steph ...
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Fazakerley, Dani ...
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Langenberg, Clau ...
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Nature Genetics
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Uppsala University
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