WFRF:(Akpinar G)
Search: WFRF:(Akpinar G) > Cross-reactive EBNA...
- 8 of 8
- Previous record
- Next record
- To hitlist
- Thomas, Olivia G.Karolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden. (author)
Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- American Association for the Advancement of Science (AAAS),2023
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-506588
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-506588URI
- https://doi.org/10.1126/sciadv.adg3032DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:152861661URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, for which and Epstein-Barr virus (EBV) infection is a likely prerequisite. Due to the homology between Epstein-Barr nuclear antigen 1 (EBNA1) and alpha-crystallin B (CRYAB), we examined antibody reactivity to EBNA1 and CRYAB peptide libraries in 713 persons with MS (pwMS) and 722 matched controls (Con). Antibody response to CRYAB amino acids 7 to 16 was associated with MS (OR = 2.0), and combination of high EBNA1 responses with CRYAB positivity markedly in-creased disease risk (OR = 9.0). Blocking experiments revealed antibody cross-reactivity between the homolo-gous EBNA1 and CRYAB epitopes. Evidence for T cell cross-reactivity was obtained in mice between EBNA1 and CRYAB, and increased CRYAB and EBNA1 CD4+ T cell responses were detected in natalizumab-treated pwMS. This study provides evidence for antibody cross-reactivity between EBNA1 and CRYAB and points to a similar cross-reactivity in T cells, further demonstrating the role of EBV adaptive immune responses in MS development.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Bronge, MattiasKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden. (author)
- Tengvall, Katarina,1980-Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden.(Swepub:uu)katst103 (author)
- Akpinar, BirceKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden. (author)
- Nilsson, Ola B.Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden. (author)
- Holmgren, ErikKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden. (author)
- Hessa, TaraKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden. (author)
- Gafvelin, GuroKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden. (author)
- Khademi, MohsenKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden. (author)
- Alfredsson, LarsKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden.;Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden. (author)
- Martin, RolandKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden.;Univ Zurich, Inst Expt Immunol, Winterthurerstr 190, CH-8057 Zurich, Switzerland. (author)
- Guerreiro-Cacais, Andre OrtliebKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden. (author)
- Grönlund, HansKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden. (author)
- Olsson, TomasKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden. (author)
- Kockum, IngridKarolinska Institutet,Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, S-17176 Stockholm, Sweden. (author)
- Karolinska InstitutetKarolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Therapeut Immune Design, S-17176 Stockholm, Sweden. (creator_code:org_t)
Related titles
- In:Science Advances: American Association for the Advancement of Science (AAAS)9:202375-2548
Internet link
Find in a library
- Science Advances (Search for host publication in LIBRIS)
To the university's database
- 8 of 8
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Thomas, Olivia G ...
- Bronge, Mattias
- Tengvall, Katari ...
- Akpinar, Birce
- Nilsson, Ola B.
- Holmgren, Erik
- show more...
- Hessa, Tara
- Gafvelin, Guro
- Khademi, Mohsen
- Alfredsson, Lars
- Martin, Roland
- Guerreiro-Cacais ...
- Grönlund, Hans
- Olsson, Tomas
- Kockum, Ingrid
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Neurology
- Articles in the publication
- Science Advances
- By the university
- Uppsala University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
