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Distinct spatial im...
Distinct spatial immune microlandscapes are independently associated with outcomes in triple-negative breast cancer
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- Carter, Jodi M. (author)
- Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada.
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- Chumsri, Saranya (author)
- Mayo Clin, Dept Med, Div Hematol & Oncol, Jacksonville, FL USA.
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- Hinerfeld, Douglas A. (author)
- Ultima Genom, Newark, CA USA.
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- Ma, Yaohua (author)
- Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Jacksonville, FL USA.
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- Wang, Xue (author)
- Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Jacksonville, FL USA.
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- Zahrieh, David (author)
- Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA.
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- Hillman, David W. (author)
- Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA.
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- Tenner, Kathleen S. (author)
- Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA.
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- Kachergus, Jennifer M. (author)
- Mayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA.
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- Brauer, Heather Ann (author)
- Bill & Melinda Gates Fdn, Seattle, WA USA.
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- Warren, Sarah E. (author)
- Kite Pharm, Santa Monica, CA USA.
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- Henderson, David (author)
- NanoString Technol Inc, Seattle, WA USA.
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- Shi, Ji (author)
- Mayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA.
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- Liu, Yi (author)
- Mayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA.
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- Joensuu, Heikki (author)
- Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.
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- Lindman, Henrik (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Klinisk onkologi
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Leon-Ferre, Roberto A. (author)
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Boughey, Judy C. (author)
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Liu, Minetta C. (author)
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Ingle, James N. (author)
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- Kalari, Krishna R. (author)
- Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA.
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Couch, Fergus J. (author)
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Knutson, Keith L. (author)
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Goetz, Matthew P. (author)
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- Perez, Edith A. (author)
- Mayo Clin, Dept Med, Div Hematol & Oncol, Jacksonville, FL USA.
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- Thompson, E. Aubrey (author)
- Mayo Clin, Dept Canc Biol, Jacksonville, FL 32224 USA.
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Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada Mayo Clin, Dept Med, Div Hematol & Oncol, Jacksonville, FL USA. (creator_code:org_t)
- Springer Nature, 2023
- 2023
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 14
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
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- The utility of spatial immunobiomarker quantitation in prognostication and therapeutic prediction is actively being investigated in triple-negative breast cancer (TNBC). Here, with high-plex quantitative digital spatial profiling, we map and quantitate intraepithelial and adjacent stromal tumor immune protein microenvironments in systemic treatment-naive (female only) TNBC to assess the spatial context in immunobiomarker-based prediction of outcome. Immune protein profiles of CD45-rich and CD68-rich stromal microenvironments differ significantly. While they typically mirror adjacent, intraepithelial microenvironments, this is not uniformly true. In two TNBC cohorts, intraepithelial CD40 or HLA-DR enrichment associates with better outcomes, independently of stromal immune protein profiles or stromal TILs and other established prognostic variables. In contrast, intraepithelial or stromal microenvironment enrichment with IDO1 associates with improved survival irrespective of its spatial location. Antigen-presenting and T-cell activation states are inferred from eigenprotein scores. Such scores within the intraepithelial compartment interact with PD-L1 and IDO1 in ways that suggest prognostic and/or therapeutic potential. This characterization of the intrinsic spatial immunobiology of treatment-naive TNBC highlights the importance of spatial microenvironments for biomarker quantitation to resolve intrinsic prognostic and predictive immune features and ultimately inform therapeutic strategies for clinically actionable immune biomarkers.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Carter, Jodi M.
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Chumsri, Saranya
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Hinerfeld, Dougl ...
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Ma, Yaohua
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Wang, Xue
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Zahrieh, David
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show more...
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Hillman, David W ...
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Tenner, Kathleen ...
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Kachergus, Jenni ...
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Brauer, Heather ...
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Warren, Sarah E.
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Henderson, David
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Shi, Ji
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Liu, Yi
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Joensuu, Heikki
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Lindman, Henrik
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Leon-Ferre, Robe ...
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Boughey, Judy C.
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Liu, Minetta C.
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Ingle, James N.
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Kalari, Krishna ...
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Couch, Fergus J.
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Knutson, Keith L ...
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Goetz, Matthew P ...
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Perez, Edith A.
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Thompson, E. Aub ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Nature Communica ...
- By the university
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Uppsala University