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Early disc degeneration in radiotherapy-treated childhood brain tumor survivors

Grahn, Petra (författare)
Univ Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.
Remes, Tiina (författare)
Oulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
Kivisaari, Reetta (författare)
Univ Helsinki, Dept Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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Suo-Palosaari, Maria. H. H. (författare)
Oulu Univ Hosp, Dept Diagnost Radiol, Oulu, Finland.;Univ Oulu, Med Res Ctr Oulu, Res Unit Med Imaging Phys & Technol, Oulu, Finland. Univ Eastern Finland, Kuopio Pediat Res Unit, Kuopio, Finland.
Arikoski, Pekka. M. M. (författare)
Kuopio Univ Hosp, Kuopio, Finland.
Koskenkorva, Paivi K. T. (författare)
Univ Eastern Finland, Dept Clin Radiol, Kuopio, Finland. Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.
Lahteenmaki, Paivi M. (författare)
Lonnqvist, Tuula R. I. (författare)
Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland.
Ojaniemi, Marja. K. K. (författare)
Univ Oulu, Res Unit Clin Med, Helsinki, Finland.
Sirkia, Kirsti H. (författare)
Helsinki Univ Hosp, Helsinki, Finland.;Univ Helsinki, Dept Pediat & Adolescence, Helsinki, Finland.
Sutela, Anna. K. K. (författare)
Univ Eastern Finland, Dept Clin Radiol, Kuopio, Finland. Turku Univ, Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.
Toiviainen-Salo, Sanna-Maria (författare)
Univ Helsinki, Dept Radiol, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
Rantala, Heikki M. J. (författare)
Oulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland.
Harila-Saari, Arja H. (författare)
Uppsala universitet,Barnonkologisk och neurologisk forskning
Niinimaki, Jaakko (författare)
Univ Oulu, Med Res Ctr Oulu, Res Unit Med Imaging Phys & Technol, Oulu, Finland. Univ Eastern Finland, Kuopio Pediat Res Unit, Kuopio, Finland.
Karppinen, Jaro (författare)
Oulu Univ Hosp, Oulu, Finland. Finnish Inst Occupat Hlth, Oulu, Finland. Rehabil Serv South Karel Social & Hlth Care Dist, Lappeenranta, Finland.
Ahonen, Matti (författare)
Univ Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland.
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Univ Helsinki, Dept Pediat Orthoped & Traumatol, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland;Helsinki Univ Hosp, Stenbackinkatu 9, PL 281, Helsinki 00029, Finland. Oulu Univ Hosp, Dept Pediat & Adolescent Med, Helsinki, Finland.;Univ Oulu, Res Unit Clin Med, Helsinki, Finland.;Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Child Neurol, Helsinki, Finland. (creator_code:org_t)
BioMed Central (BMC), 2023
2023
Engelska.
Ingår i: BMC Musculoskeletal Disorders. - : BioMed Central (BMC). - 1471-2474. ; 24:1
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BackgroundChildhood brain tumor (BT) survivors have an increased risk of treatment-related late effects, which can reduce health-related quality of life and increase morbidity. This study aimed to investigate lumbar disc degeneration in magnetic resonance imaging (MRI) in adult survivors of radiotherapy-treated childhood BT compared to age and sex-matched population controls.MethodsIn this cross-sectional comparative study, 127 survivors were identified from hospital registries. After a mean follow-up of 20.7 years (range 5-33.1), 67 survivors (mean age 28.4, range 16.2-43.5) were investigated with MRI and compared to 75 sex-matched population-based controls. Evaluated MRI phenotypes included Pfirrmann grading, , intervertebral disc protrusions, extrusions, and high-intensity-zone-lesions (HIZ). Groups were also compared for known risk factors of lumbar intervertebral disc (IVD) degeneration.ResultsChildhood BT survivors had higher Pfirrmann grades than controls at all lumbar levels (all p < 0.001). Lumbar disc protrusions at L4-5 (p = 0.02) and extrusions at L3-4 (p = 0.04), L4-5 (p = 0.004), and L5-S1 (p = 0.01) were significantly more common in the BT group compared to the control. The survivor cohort also had significantly more HIZ-lesons than the controls (n=13 and n=1, p=0.003). Age at diagnosis was associated with lower degree of IVD degeneration (p < 0.01). Blood pressure correlated with IVD degeneration (P < 0.05).ConclusionsSigns of early disc degeneration related to tumor treatment can be seen in the IVDs of survivors. Disc degeneration was more severe in children treated in adolescence.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Ortopedi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopaedics (hsv//eng)

Nyckelord

Childhood brain tumor survivor
Radiotherapy
Disc degeneration

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