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Network analysis of...
Network analysis of chromophore binding site in LOV domain
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- Panda, Rishab (författare)
- Indian Inst Sci Educ & Res Mohali, Dept Chem Sci, Mohali, Punjab, India.
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- Panda, Pritam Kumar, PhD Student, 1991- (författare)
- Uppsala universitet,Materialteori,Karolinska Inst, Inst Environm Med, Div Immunol & Chron Dis, Stockholm, Sweden.
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- Krishnamoorthy, Janarthanan (författare)
- Jimma Univ, Jimma Inst Technol, Sch Biomed Engn, Jimma 378, Ethiopia.
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- Kar, Rajiv K. (författare)
- Indian Inst Technol Guwahati, Jyoti & Bhupat Mehta Sch Hlth Sci & Technol, Gauhati 781039, Assam, India.
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Indian Inst Sci Educ & Res Mohali, Dept Chem Sci, Mohali, Punjab, India Materialteori (creator_code:org_t)
- PERGAMON-ELSEVIER SCIENCE LTD, 2023
- 2023
- Engelska.
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Ingår i: Computers in Biology and Medicine. - : PERGAMON-ELSEVIER SCIENCE LTD. - 0010-4825 .- 1879-0534. ; 161
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Photoreceptor proteins are versatile toolbox for developing biosensors for optogenetic applications. These molecular tools get activated upon illumination of blue light, which in turn offers a non-invasive method for gaining high spatiotemporal resolution and precise control of cellular signal transduction. The Light-Oxygen-Voltage (LOV) domain family of proteins is a well-recognized system for constructing optogenetic devices. Translation of these proteins into efficient cellular sensors is possible by tuning their photochemistry lifetime. However, the bottleneck is the need for more understanding of the relationship between the protein environment and photocycle kinetics. Significantly, the effect of the local environment also modulates the electronic structure of chromophore, which perturbs the electrostatic and hydrophobic interaction within the binding site. This work highlights the critical factors hidden in the protein networks, linking with their experimental photocycle kinetics. It presents an opportunity to quantitatively examine the alternation in chromophore's equilibrium geometry and identify details which have substantial implications in designing synthetic LOV constructs with desirable photocycle efficiency.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
Nyckelord
- LOV domain
- Protein network
- Normal mode analysis
- Hybrid QM/MM
- Flavin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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