SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Lange Tanja)
 

Search: WFRF:(Lange Tanja) > Prognostic Impact o...

  • Lübke, JohannesHeidelberg Univ, Univ Hosp Mannheim, Dept Hematol & Oncol, Mannheim, Germany. (author)

Prognostic Impact of Organomegaly in Mastocytosis : An Analysis of the European Competence Network on Mastocytosis

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Elsevier,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-507040
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-507040URI
  • https://doi.org/10.1016/j.jaip.2022.10.051DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:152841587URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND: Organomegaly, including splenomegaly, hepatomegaly, and/or lymphadenopathy, are important diagnostic and prognostic features in patients with cutaneous mastocytosis (CM) or systemic mastocytosis (SM).OBJECTIVES: To investigate the prevalence and prognostic impact of 1 or more organomegalies on clinical course and survival in patients with CM/SM.METHODS: Therefore, 3155 patients with CM (n = 1002 [32%]) or SM (n = 2153 [68%]) enrolled within the registry of the European Competence Network on Mastocytosis were analyzed. RESULTS: Overall survival (OS) was adversely affected by the number of organomegalies (OS: #0 vs #1 hazard ratio [HR], 4.9; 95% CI, 3.4-7.1, P < .001; #1 vs #2 HR, 2.1, 95% CI, 1.4-3.1, P < .001; #2 vs #3 HR, 1.7, 95% CI, 1.2-2.5, P = .004). Lymphadenopathy was frequently detected in patients with smoldering SM (SSM, 18 of 60 [30%]) or advanced SM (AdvSM, 137 of 344 [40%]). Its presence confered an inferior outcome in patients with AdvSM compared with patients with AdvSM without lymphadenopathy (median OS, 3.8 vs 2.6 years; HR, 1.6; 95% CI, 1.2-2.2; P = .003). OS was not different between patients having organomegaly with either ISM or SSM (median, 25.5 years vs not reached; P = .435). At time of disease progression, a new occurrence of any organomegaly was observed in 17 of 40 (43%) patients with ISM, 4 of 10 (40%) patients with SSM, and 33 of 86 (38%) patients with AdvSM, respectively.CONCLUSIONS: Organomegalies including lymphadenopathy are often found in SSM and AdvSM. ISM with organomegaly has a similar course and prognosis compared with SSM. The number of organomegalies is adversely associated with OS. A new occurrence of organomegaly in all variants of SM may indicate disease progression.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Schwaab, JulianaHeidelberg Univ, Univ Hosp Mannheim, Dept Hematol & Oncol, Mannheim, Germany. (author)
  • Christen, DeborahUniv Hosp RWTH Aachen, Dept Oncol Haematol Haemostaseol & Stem Cell Tran, Aachen, Germany. (author)
  • Elberink, Hanneke OudeUniv Groningen, Univ Med Ctr Groningen, Dept Allergol, Groningen, Netherlands. (author)
  • Span, BartUniv Groningen, Univ Med Ctr Groningen, Dept Hematol, Groningen, Netherlands. (author)
  • Niedoszytko, MarekMed Univ Gdansk, Dept Allergol, Gdansk, Poland. (author)
  • Gorska, AleksandraMed Univ Gdansk, Dept Allergol, Gdansk, Poland. (author)
  • Lange, MagdalenaMed Univ Gdansk, Dept Dermatol, Gdansk, Poland. (author)
  • Gleixner, Karoline V.Med Univ Vienna, Dept Int Med 1, Div Hematol & Hemostaseol, Vienna, Austria.;Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria. (author)
  • Hadzijusufovic, EmirMed Univ Vienna, Dept Int Med 1, Div Hematol & Hemostaseol, Vienna, Austria.;Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria.;Univ Vet Med, Univ Clin Small Anim, Dept Univ Clin Compan Anim & Horses, Internal Med Small Anim, Vienna, Austria. (author)
  • Solomianyi, OleksiiJohannes Kepler Univ Linz, Univ Clin Hematol & Oncol, Kepler Univ Hosp, Linz, Austria. (author)
  • Angelova-Fischer, IrenaJohannes Kepler Univ Linz, Kepler Univ Hosp, Allergy Ctr, Dept Dermatol & Venereol, Linz, Austria. (author)
  • Zanotti, RobertaVerona Univ Hosp, Dept Med, Sect Hematol, Verona, Italy. (author)
  • Bonifacio, MassimilianoVerona Univ Hosp, Dept Med, Sect Hematol, Verona, Italy. (author)
  • Bonadonna, PatriziaVerona Univ Hosp, Allergy Unit, Verona, Italy. (author)
  • Shoumariyeh, KhalidUniv Freiburg, Fac Med, Med Ctr, Dept Hematol & Oncol, Freiburg, Germany.;German Canc Consortium DKTK Partner Site Freiburg, Freiburg, Germany. (author)
  • von Bubnoff, NikolasUniv Freiburg, Fac Med, Med Ctr, Dept Hematol & Oncol, Freiburg, Germany.;German Canc Consortium DKTK Partner Site Freiburg, Freiburg, Germany.;Univ Schleswig Holstein, Med Ctr, Dept Hematol & Oncol, Campus Lubeck, Lubeck, Germany. (author)
  • Mueller, SabineUniv Freiburg, Fac Med, Med Ctr, Dept Dermatol, Freiburg, Germany. (author)
  • Perkins, CeceliaStanford Univ, Sch Med, Dept Med, Div Hematol, Stanford, CA 94305 USA. (author)
  • Elena, ChiaraUniv Pavia, Dept Mol Med, Pavia, Italy.;Univ Pavia, Dept Hematol Oncol, Pavia, Italy.;Fdn IRCCS Policlin San Matteo, Pavia, Italy. (author)
  • Malcovati, LucaUniv Pavia, Dept Mol Med, Pavia, Italy.;Univ Pavia, Dept Hematol Oncol, Pavia, Italy.;Fdn IRCCS Policlin San Matteo, Pavia, Italy. (author)
  • Hägglund, HansUppsala universitet,Hematologi,Uppsala Univ, Dept Med Sci, Div Hematol, Uppsala, Sweden.(Swepub:uu)hanha689 (author)
  • Mattsson, MattiasUppsala universitet,Hematologi(Swepub:uu)matma431 (author)
  • Parente, RobertaUniv Salerno, Div Allergy & Clin Immunol, Salerno, Italy. (author)
  • Varkonyi, JuditSemmelwe Univ, Dept Hematol, Budapest, Hungary. (author)
  • Fortina, Anna BelloniUniv Padua, Dept Med, Pediat Dermatol Unit, Padua, Italy. (author)
  • Caroppo, FrancescaUniv Padua, Dept Med, Pediat Dermatol Unit, Padua, Italy. (author)
  • Zink, AlexanderKarolinska Institutet,Techn Univ Munchen, Fac Med, Dept Dermatol & Allergy Biederstein, Munich, Germany. (author)
  • Brockow, KnutTechn Univ Munchen, Fac Med, Dept Dermatol & Allergy Biederstein, Munich, Germany. (author)
  • Breynaert, ChristineKatholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Allergy & Clin Immunol Res Grp, Leuven, Belgium.;Univ Hosp Leuven, MASTeL, Leuven, Belgium. (author)
  • Bullens, DominiqueKatholieke Univ Leuven, Dept Microbiol Immunol & Transplantat, Allergy & Clin Immunol Res Grp, Leuven, Belgium.;Univ Hosp Leuven, MASTeL, Leuven, Belgium. (author)
  • Yavuz, Akif SelimIstanbul Univ, Istanbul Med Sch, Div Hematol, Istanbul, Turkiye. (author)
  • Doubek, MichaelUniv Hosp & Fac Med, Brno, Czech Republic. (author)
  • Sabato, VitoUniv Antwerp, Fac Med & Hlth Sci, Dept Immunol Allergol Rheumatol, Antwerp, Belgium.;Antwerp Univ Hosp, Antwerp, Belgium. (author)
  • Schug, TanjaUniv Hosp Graz, Dept Dermatol & Venereol, Graz, Austria. (author)
  • Niederwieser, DietgerUniv Hosp Leipzig, Leipzig, Germany. (author)
  • Hartmann, KarinUniv Basel, Dept Dermatol, Div Allergy, Basel, Switzerland.;Uni Hosp Basel, Dept Biomed, Basel, Switzerland.;Univ Basel, Basel, Switzerland. (author)
  • Triggiani, MassimoUniv Salerno, Div Allergy & Clin Immunol, Salerno, Italy. (author)
  • Gotlib, JasonStanford Univ, Sch Med, Dept Med, Div Hematol, Stanford, CA 94305 USA. (author)
  • Hermine, OlivierUniv Paris 05, Hop Necker, AP HP, Imagine Inst,French Reference Ctr Mastocytosis CE, Paris, France. (author)
  • Arock, MichelHop La Pitie Salpetriere, Lab Hematol, Paris, France. (author)
  • Kluin-Nelemans, Hanneke C.Univ Groningen, Univ Med Ctr Groningen, Dept Hematol, Groningen, Netherlands. (author)
  • Panse, JensUniv Hosp RWTH Aachen, Dept Oncol Haematol Haemostaseol & Stem Cell Tran, Aachen, Germany.;Aachen Bonn Cologne Dusseldorf CIO ABCD, Ctr Integrated Oncol, Aachen, Germany. (author)
  • Sperr, Wolfgang R.Med Univ Vienna, Dept Int Med 1, Div Hematol & Hemostaseol, Vienna, Austria.;Med Univ Vienna, Ludwig Boltzmann Inst Hematol & Oncol, Vienna, Austria. (author)
  • Valent, Peter (author)
  • Reiter, AndreasHeidelberg Univ, Univ Hosp Mannheim, Dept Hematol & Oncol, Mannheim, Germany. (author)
  • Jawhar, MohamadHeidelberg Univ, Univ Hosp Mannheim, Dept Hematol & Oncol, Mannheim, Germany. (author)
  • Heidelberg Univ, Univ Hosp Mannheim, Dept Hematol & Oncol, Mannheim, Germany.Univ Hosp RWTH Aachen, Dept Oncol Haematol Haemostaseol & Stem Cell Tran, Aachen, Germany. (creator_code:org_t)

Related titles

  • In:Journal of Allergy and Clinical Immunology: Elsevier11:2, s. 581-5902213-21982213-2201

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view