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Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
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- Ollila, Hanna M. (author)
- Stanford Univ, Dept Psychiat & Behav Sci, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA.;Univ Helsinki, Inst Mol Med Finland, HiLIFE, Helsinki, Finland.;Massachusetts Gen Hosp, Anesthesia Crit Care & Pain Med, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.;Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA USA.
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- Sharon, Eilon (author)
- Stanford Univ, Dept Genet, Stanford, CA 94305 USA.;Stanford Univ, Dept Biol, Stanford, CA 94305 USA.
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- Lin, Ling (author)
- Stanford Univ, Dept Psychiat & Behav Sci, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA.
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show more...
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- Sinnott-Armstrong, Nasa (author)
- Stanford Univ, Dept Genet, Stanford, CA 94305 USA.;Stanford Univ, Dept Biol, Stanford, CA 94305 USA.
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- Ambati, Aditya (author)
- Stanford Univ, Dept Psychiat & Behav Sci, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA.
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- Yogeshwar, Selina M. (author)
- Stanford Univ, Dept Psychiat & Behav Sci, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA.;Charite, Dept Neurol, D-10117 Berlin, Germany.;Charite, Einstein Ctr Neurosci Berlin, D-10117 Berlin, Germany.
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- Hillary, Ryan P. (author)
- Stanford Univ, Dept Psychiat & Behav Sci, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA.
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Jolanki, Otto (author)
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- Faraco, Juliette (author)
- Stanford Univ, Dept Psychiat & Behav Sci, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA.
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- Einen, Mali (author)
- Stanford Univ, Dept Psychiat & Behav Sci, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA.
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- Luo, Guo (author)
- Stanford Univ, Dept Psychiat & Behav Sci, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA.
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- Zhang, Jing (author)
- Stanford Univ, Dept Psychiat & Behav Sci, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA.
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- Han, Fang (author)
- Peking Univ Peoples Hosp, Div Sleep Med, Beijing, Peoples R China.
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- Yan, Han (author)
- Peking Univ Peoples Hosp, Div Sleep Med, Beijing, Peoples R China.
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- Dong, Xiao Song (author)
- Peking Univ Peoples Hosp, Div Sleep Med, Beijing, Peoples R China.
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- Li, Jing (author)
- Peking Univ Peoples Hosp, Div Sleep Med, Beijing, Peoples R China.
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- Zhang, Jun (author)
- Peking Univ Peoples Hosp, Dept Neurol, Beijing, Peoples R China.
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- Hong, Seung-Chul (author)
- Catholic Univ Korea, St Vincents Hosp, Dept Psychiat, Suwon, South Korea.
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- Kim, Tae Won (author)
- Catholic Univ Korea, St Vincents Hosp, Dept Psychiat, Suwon, South Korea.
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- Dauvilliers, Yves (author)
- Univ Montpellier I, Gui De Chauliac Hosp,INSERM, CHU Montpellier,Inst Neurosci Montpellier INM, Dept Neurol,Sleep Wake Disorders Ctr,Natl Referen, Montpellier, France.
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- Barateau, Lucie (author)
- Univ Montpellier I, Gui De Chauliac Hosp,INSERM, CHU Montpellier,Inst Neurosci Montpellier INM, Dept Neurol,Sleep Wake Disorders Ctr,Natl Referen, Montpellier, France.
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- Lammers, Gert Jan (author)
- Leiden Univ, Med Ctr, Dept Neurol, Leiden, Netherlands.;Stichting Epilepsie Instellingen Nederland SEIN, Sleep Wake Ctr, Heemstede, Netherlands.
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- Fronczek, Rolf (author)
- Leiden Univ, Med Ctr, Dept Neurol, Leiden, Netherlands.;Stichting Epilepsie Instellingen Nederland SEIN, Sleep Wake Ctr, Heemstede, Netherlands.
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- Mayer, Geert (author)
- Hephata Klin, Schimmelpfengstr 6, D-34613 Schwalmstadt, Germany.;Philipps Univ Marburg, Baldinger Str, D-35043 Marburg, Germany.
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- Santamaria, Joan (author)
- Univ Barcelona, Inst Neurociencies Hosp Clin, Neurol Serv, Barcelona, Spain.
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- Arnulf, Isabelle (author)
- Hop La Pitie Salpetriere, AP HP, Sleep Disorder Unit, F-75013 Paris, France.
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- Knudsen-Heier, Stine (author)
- Oslo Univ Hosp, Dept Rare Disorders, Norwegian Ctr Expertise Neurodeve Disor, Oslo, Norway.;Univ Oslo, Oslo, Norway.
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- Bredahl, May Kristin Lyamouri (author)
- Oslo Univ Hosp, Dept Rare Disorders, Norwegian Ctr Expertise Neurodeve Disor, Oslo, Norway.;Univ Oslo, Oslo, Norway.;Oslo Univ Hosp, Dept Med Biochem, Hormone Lab, Oslo, Norway.
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- Thorsby, Per Medboe (author)
- Oslo Univ Hosp, Dept Med Biochem, Hormone Lab, Oslo, Norway.
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- Plazzi, Giuseppe (author)
- Univ Bologna, Dept Biomed & Neuromotor Sci DIBINEM, Via Ugo Foscolo 7, I-40123 Bologna, Italy.;IRCCS Inst Neurol Sci, Bologna, Italy.
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- Pizza, Fabio (author)
- Univ Bologna, Dept Biomed & Neuromotor Sci DIBINEM, Via Ugo Foscolo 7, I-40123 Bologna, Italy.;IRCCS Inst Neurol Sci, Bologna, Italy.
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- Moresco, Monica (author)
- Univ Bologna, Dept Biomed & Neuromotor Sci DIBINEM, Via Ugo Foscolo 7, I-40123 Bologna, Italy.;IRCCS Inst Neurol Sci, Bologna, Italy.
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- Crowe, Catherine (author)
- Mater Private Hosp, Dublin 7, Ireland.
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- Van den Eeden, Stephen K. (author)
- Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA.
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- Lecendreux, Michel (author)
- Pediat Sleep Ctr & Natl Reference Ctr Narcolepsy, Paris, France.
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- Bourgin, Patrice (author)
- Univ Strasbourg, Strasbourg Univ Hosp, Dept Sleep Med, Strasbourg, France.
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- Kanbayashi, Takashi (author)
- Akita Univ, Grad Sch Med, Dept Neuropsychiat, Akita, Japan.;Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, Tsukuba, Ibaraki, Japan.
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- Martinez-Orozco, Francisco J. (author)
- Univ Complutense Madrid, San Carlos Univ Hosp, Clin Neurophysiol Serv, Sleep Unit, Madrid, Spain.
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- Peraita-Adrados, Rosa (author)
- Univ Complutense Madrid UCM, Gregorio Maranon Univ Gen Hosp & Res Inst, Sleep & Epilepsy Unit, Clin Neurophysiol Serv, Madrid, Spain.
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- Beneto, Antonio (author)
- Med Ctr Valencia, Sleep Unit, Valencia, Spain.
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- Montplaisir, Jacques (author)
- Univ Montreal, Hop Sacre Coeur & Dept Neurosci, Ctr Adv Res Sleep Med, Montreal, PQ, Canada.
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- Desautels, Alex (author)
- Univ Montreal, Hop Sacre Coeur & Dept Neurosci, Ctr Adv Res Sleep Med, Montreal, PQ, Canada.
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- Huang, Yu-Shu (author)
- Chang Gung Mem Hosp & Univ, Dept Child Psychiat & Sleep Ctr, Taoyuan, Taiwan.
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- FinnGen, Poul Jennum (author)
- Univ Copenhagen, Glostrup Hosp, Dept Clin Neurophysiol, Danish Ctr Sleep Med, Glostrup, Denmark.
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Jennum, Poul (author)
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- Nevsimalova, Sona (author)
- Charles Univ & Gen Univ Hosptal, First Fac Med, Dept Neurol & Ctr Clin Neurosci, Prague, Czech Republic.
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- Kemlink, David (author)
- Charles Univ & Gen Univ Hosptal, First Fac Med, Dept Neurol & Ctr Clin Neurosci, Prague, Czech Republic.
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- Iranzo, Alex (author)
- Inst Invest Biomed August Pi & Sunyer ID, Barcelona, Spain.;Dept Neurol, Barcelona, Spain.;Multidisciplinary Sleep Disorders Unit, Barcelona, Spain.
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- Overeem, Sebastiaan (author)
- Sleep Med Ctr Kempenhaeghe, POB 61, NL-5590 AB Heeze, Netherlands.;Eindhoven Univ Technol, Eindhoven, Netherlands.
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- Wierzbicka, Aleksandra (author)
- Inst Psychiat & Neurol, Dept Clin Neurophysiol, Warsaw, Poland.
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- Geisler, Peter (author)
- Univ Regensburg, Dept Psychiat & Psychotherapy, Regensburg, Germany.
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- Sonka, Karel (author)
- Charles Univ & Gen Univ Hosptal, First Fac Med, Dept Neurol & Ctr Clin Neurosci, Prague, Czech Republic.
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- Honda, Makoto (author)
- Tokyo Metropolitan Inst Med Sci, Dept Psychiat & Behav Sci, Tokyo, Japan.;Seiwa Hosp, Neuropsychiatr Res Inst, Tokyo, Japan.
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- Högl, Birgit (author)
- Med Univ Innsbruck MUI, Dept Neurol, Innsbruck, Austria.
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- Stefani, Ambra (author)
- Med Univ Innsbruck MUI, Dept Neurol, Innsbruck, Austria.
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- Coelho, Fernando Morgadinho (author)
- Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil.
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- Mantovani, Vilma (author)
- St Orsola Malpighi Univ Hosp, Ctr Appl Biomed Res CRBA, Bologna, Italy.
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- Feketeova, Eva (author)
- Safarik Univ, Univ Hosp L Pasteur Kosice, Neurol Dept, Med Fac, Kosice, Slovakia.
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- Wadelius, Mia (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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- Eriksson, Niclas, 1978- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab
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- Smedje, Hans (author)
- Karolinska Inst, Div Child & Adolescent Psychiat, Stockholm, Sweden.
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- Hallberg, Pär, 1974- (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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- Hesla, Per Egil (author)
- Coliseum Majorstua Clin, Oslo, Norway.
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- Rye, David (author)
- Emory Univ, Dept Neurol, Sch Med, Atlanta, GA USA.
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- Pelin, Zerrin (author)
- Hasan Kalyoncu Univ, Fac Hlth Sci, Gaziantep, Turkiye.
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- Ferini-Strambi, Luigi (author)
- Hasan Kalyoncu Univ, Fac Hlth Sci, Gaziantep, Turkiye.
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- Bassetti, Claudio L. (author)
- Univ Vita Salute, Osped San Raffaele, Div Neurosci, Sleep Disorders Ctr, Milan, Italy.;Osped Regionale Lugano, Dept Neurol, EOC, Lugano, Switzerland.
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- Mathis, Johannes (author)
- Osped Regionale Lugano, Dept Neurol, EOC, Lugano, Switzerland.
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- Khatami, Ramin (author)
- Osped Regionale Lugano, Dept Neurol, EOC, Lugano, Switzerland.;Univ Hosp Bern, Inselspital, Dept Neurol, Bern, Switzerland.;Univ Bern, Bern, Switzerland.
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- Aran, Adi (author)
- Clin Barmelweid AG, Ctr Sleep Med & Sleep Res, Barmelweid, Switzerland.
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- Nampoothiri, Sheela (author)
- Shaare ZedekMed Ctr, Jerusalem, Israel.
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- Olsson, Tomas (author)
- Karolinska Institutet
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- Kockum, Ingrid (author)
- Karolinska Institutet
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- Partinen, Markku (author)
- Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Helsinki Sleep Clin, Vitalmed Res Ctr, Helsinki, Finland.
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- Perola, Markus (author)
- Univ Helsinki, Dept Clin Neurosci, Helsinki, Finland.
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- Kornum, Birgitte R. (author)
- Univ Tartu, Univ Helsinki, Inst Mol Med, Estonian Genome Ctr,Finland FIMM & Diabet & Obes, Tartu, Estonia.
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- Rueger, Sina (author)
- Univ Copenhagen, Dept Neurosci, Copenhagen, Denmark.
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- Winkelmann, Juliane (author)
- Swiss Inst Bioinformat, Lausanne, Switzerland.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Neurogen, Neuherberg, Germany.;Munich Cluster Syst Neurol SyNergy, Munich, Germany.
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Miyagawa, Taku (author)
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Toyoda, Hiromi (author)
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- Khor, Seik-Soon (author)
- Univ Munich, Klinikum Rechts Isar Techn, Neurolog Klin & Poliklin, Munich, Germany.
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- Shimada, Mihoko (author)
- Univ Munich, Klinikum Rechts Isar Techn, Neurolog Klin & Poliklin, Munich, Germany.
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- Tokunaga, Katsushi (author)
- Univ Munich, Klinikum Rechts Isar Techn, Neurolog Klin & Poliklin, Munich, Germany.
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- Rivas, Manuel (author)
- Univ Tokyo, Grad Sch Med, Dept Human Genet, Tokyo, Japan.
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Pritchard, Jonathan K. (author)
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- Risch, Neil (author)
- Stanford Univ, Dept Biomed Data Sci Adm, Palo Alto, CA USA.
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- Kutalik, Zoltan (author)
- UCSF, Dept Epidemiol & Biostat, 513 Parnassus Ave, San Francisco, CA 94117 USA.
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- O'Hara, Ruth (author)
- Univ Lausanne, Univ Ctr Primary Care & Publ Hlth, Lausanne, Switzerland.;Stanford Univ, Dept Psychiat & Behav Sci, Palo Alto, CA USA.;Mental Illness Res Educ Clin Centers MIRECC, Palo Alto, CA USA.
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- Hallmayer, Joachim (author)
- Univ Lausanne, Univ Ctr Primary Care & Publ Hlth, Lausanne, Switzerland.;Stanford Univ, Dept Psychiat & Behav Sci, Palo Alto, CA USA.
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- Ye, Chun Jimmie (author)
- Univ Calif San Francisco, Inst Human Genet, Dept Epidemiol Biostat, San Francisco, CA USA.
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- Mignot, Emmanuel J. (author)
- Stanford Univ, Dept Psychiat & Behav Sci, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA.
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Stanford Univ, Dept Psychiat & Behav Sci, Ctr Sleep Sci & Med, Palo Alto, CA 94304 USA;Univ Helsinki, Inst Mol Med Finland, HiLIFE, Helsinki, Finland.;Massachusetts Gen Hosp, Anesthesia Crit Care & Pain Med, Boston, MA USA.;Harvard Med Sch, Boston, MA USA.;Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA USA. Stanford Univ, Dept Genet, Stanford, CA 94305 USA.;Stanford Univ, Dept Biol, Stanford, CA 94305 USA. (creator_code:org_t)
- Springer Nature, 2023
- 2023
- English.
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 14
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Narcolepsy type 1 (NT1) is caused by a loss of hypocretin/orexin transmission. Risk factors include pandemic 2009 H1N1 influenza A infection and immunization with Pandemrix (R). Here, we dissect disease mechanisms and interactions with environmental triggers in a multi-ethnic sample of 6,073 cases and 84,856 controls. We fine-mapped GWAS signals within HLA (DQ0602, DQB1*03:01 and DPB1*04:02) and discovered seven novel associations (CD207, NAB1, IKZF4-ERBB3, CTSC, DENND1B, SIRPG, PRF1). Significant signals at TRA and DQB1*06:02 loci were found in 245 vaccination-related cases, who also shared polygenic risk. T cell receptor associations in NT1 modulated TRAJ*24, TRAJ*28 and TRBV*4-2 chain-usage. Partitioned heritability and immune cell enrichment analyses found genetic signals to be driven by dendritic and helper T cells. Lastly comorbidity analysis using data from FinnGen, suggests shared effects between NT1 and other autoimmune diseases. NT1 genetic variants shape autoimmunity and response to environmental triggers, including influenza A infection and immunization with Pandemrix (R).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ollila, Hanna M.
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Sharon, Eilon
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Lin, Ling
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Sinnott-Armstron ...
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Ambati, Aditya
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Yogeshwar, Selin ...
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Hillary, Ryan P.
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Jolanki, Otto
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Faraco, Juliette
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Einen, Mali
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Luo, Guo
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Zhang, Jing
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Han, Fang
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Yan, Han
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Dong, Xiao Song
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Li, Jing
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Zhang, Jun
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Hong, Seung-Chul
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Kim, Tae Won
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Dauvilliers, Yve ...
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Barateau, Lucie
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Lammers, Gert Ja ...
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Fronczek, Rolf
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Mayer, Geert
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Santamaria, Joan
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Arnulf, Isabelle
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Knudsen-Heier, S ...
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Bredahl, May Kri ...
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Thorsby, Per Med ...
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Plazzi, Giuseppe
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Pizza, Fabio
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Moresco, Monica
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Crowe, Catherine
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Van den Eeden, S ...
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Lecendreux, Mich ...
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Bourgin, Patrice
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Kanbayashi, Taka ...
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Martinez-Orozco, ...
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Peraita-Adrados, ...
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Beneto, Antonio
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Montplaisir, Jac ...
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Desautels, Alex
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Huang, Yu-Shu
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FinnGen, Poul Je ...
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Jennum, Poul
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Nevsimalova, Son ...
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Kemlink, David
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Iranzo, Alex
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Overeem, Sebasti ...
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Wierzbicka, Alek ...
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Geisler, Peter
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Sonka, Karel
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Honda, Makoto
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Högl, Birgit
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Stefani, Ambra
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Coelho, Fernando ...
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Mantovani, Vilma
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Feketeova, Eva
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Wadelius, Mia
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Eriksson, Niclas ...
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Smedje, Hans
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Hallberg, Pär, 1 ...
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Hesla, Per Egil
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Rye, David
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Pelin, Zerrin
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Ferini-Strambi, ...
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Bassetti, Claudi ...
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Mathis, Johannes
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Khatami, Ramin
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Aran, Adi
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Nampoothiri, She ...
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Olsson, Tomas
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Kockum, Ingrid
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Partinen, Markku
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Perola, Markus
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Kornum, Birgitte ...
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Rueger, Sina
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Winkelmann, Juli ...
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Miyagawa, Taku
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Toyoda, Hiromi
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Khor, Seik-Soon
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Shimada, Mihoko
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Tokunaga, Katsus ...
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Rivas, Manuel
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Pritchard, Jonat ...
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Risch, Neil
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Kutalik, Zoltan
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O'Hara, Ruth
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Hallmayer, Joach ...
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Ye, Chun Jimmie
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Mignot, Emmanuel ...
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MEDICAL AND HEAL ...
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MEDICAL AND HEAL ...
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Uppsala University
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Karolinska Institutet