Sökning: L773:1873 5169 OR L773:0196 9781 >
Differential metabo...
Differential metabolism of dynorphins in substantia nigra, striatum and hippocampus
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Sandin, Johan (författare)
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Tan No, Koichi (författare)
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Kasakov, Lubomir (författare)
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- Nylander, Ingrid (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Pharmacology
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Winter, Anders (författare)
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Silberring, Jerzy (författare)
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Terenius, Lars (författare)
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(creator_code:org_t)
- 1997
- 1997
- Engelska.
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Ingår i: Peptides. - 0196-9781 .- 1873-5169. ; 18:7, s. 949-956
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- To map the proteolytic enzymes metabolizing dynorphins in brain structures, size-exclusion chromatography linked to electrospray ionization mass spectrometry was used. Enzymes extracted from rat hippocampus, striatum, and substantia nigra were tested for their capability of converting dynorphin-related peptides. Dynorphin A was the most resistant to proteolytic conversion, whereas Big dynorphin and dynorphin B-29 were slowly converted to dynorphin A and dynorphins A and B, respectively. Dynorphin B and alpha-neoendorphin were the least resistant. Dynorphin B was rapidly converted to Leu-enkephalin in the striatum and hippocampus but to Leu-enkephalin-Arg6 in the substantia nigra. alpha-Neoendorphin was converted to Leu-enkephalin in all tissues investigated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- dynorphin
- enkephalin
- peptidases
- metabolism
- HPLC
- mass spectrometry
- PHARMACY
- FARMACI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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