Plasma cytokine levels in spinal surgery with sevoflurane or total intravenous propofol anesthesia: A post hoc analysis of a randomized controlled trial

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Franzén, StephanieUppsala universitet,Anestesiologi och intensivvård (författare)

Plasma cytokine levels in spinal surgery with sevoflurane or total intravenous propofol anesthesia : A post hoc analysis of a randomized controlled trial

Artikel/kapitelEngelska2023

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Elsevier,2023
electronicrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-507421
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-507421URI
https://doi.org/10.1016/j.cyto.2023.156290DOI

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Språk:engelska
Sammanfattning på:engelska

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Anmärkningar

Surgical tissue trauma stimulates an inflammatory response resulting in increased levels of cytokines which could contribute to acute kidney injury (AKI). It is not clear if anesthetic modality affects this response. We aimed to investigate the role of anesthesia in a healthy surgical population on the inflammatory response and the correlation to plasma creatinine. This study is a post hoc analysis of a published randomized clinical trial. We analyzed plasma from patients who underwent elective spinal surgery randomized to either total intravenous propofol anesthesia (n = 12) or sevoflurane anesthesia (n = 10). The plasma samples were collected before anesthesia, during anesthesia, and 1 h after surgery. Plasma cytokine levels after surgery were analyzed for correlations with duration of surgical insult and change in plasma creatinine concentration. The cytokine interleukin-6 (IL-6) was increased after surgery compared with preoperatively. IL-6 was higher in the sevoflurane group than the propofol group after surgery. No patient developed AKI, but plasma creatinine was increased postoperatively in the sevoflurane group. There was a significant association between surgical time and plasma IL-6 postoperatively. No significant correlation between change in plasma creatinine and IL-6 was detected. The cytokines IL-4, IL-13, Eotaxin, Interferon γ-Induced Protein 10 (IP-10), Granulocyte Colony-Stimulating Factor (G-CSF), Macrophage Inflammatory Protein-1β (MIP-1β), and Monocyte Chemoattractant Protein 1 (MCP-1) were lower postoperatively than before surgery independent of anesthetic modality. This post hoc analysis revealed that plasma IL-6 was increased after surgery and more so in the sevoflurane group than the propofol group. Postoperative plasma IL-6 concentration was associated with surgical time.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Anestesi och intensivvård hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Anesthesiology and Intensive Care hsv//eng
Acute kidney injury
Interleukin-6
Propofol
Sevoflurane
Surgery

Biuppslag (personer, institutioner, konferenser, titlar ...)

Semenas, EgidijusUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)egise198 (författare)
Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andlarss (författare)
Hultström, Michael,1978-Uppsala universitet,Anestesiologi och intensivvård,Institutionen för medicinsk cellbiologi(Swepub:uu)mihul498 (författare)
Frithiof, RobertUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)robfr118 (författare)
Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)

Sammanhörande titlar

Ingår i:Cytokine: Elsevier1691043-46661096-0023

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Av författaren/redakt...: Franzén, Stephan ...; Semenas, Egidiju ...; Larsson, Anders; Hultström, Micha ...; Frithiof, Robert

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Anestesi och int ...

Artiklar i publikationen: Cytokine

Av lärosätet: Uppsala universitet

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