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Sökning: (WFRF:(Quertermous Thomas)) pers:(Knowles Joshua W.) > (2020-2023) > Single-cell transcr...

Single-cell transcriptome dataset of human and mouse in vitro adipogenesis models

Li, Jiehan (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA.
Jin, Christopher (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.
Gustafsson, Stefan (författare)
Uppsala universitet,Klinisk epidemiologi
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Rao, Abhiram (författare)
Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA.
Wabitsch, Martin (författare)
Ulm Univ, Ctr Rare Endocrine Dis, Dept Pediat & Adolescent Med, Div Pediat Endocrinol & Diabet,Med Ctr, D-89075 Ulm, Germany.
Park, Chong Y. (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA.
Quertermous, Thomas (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA.
Knowles, Joshua W. (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Prevent Res Ctr, Sch Med, Stanford, CA 94305 USA.
Bielczyk-Maczynska, Ewa (författare)
Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Diabet Res Ctr, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA.
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Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA;Stanford Univ, Stanford Diabet Res Ctr, Sch Med, Stanford, CA 94305 USA.;Stanford Univ, Stanford Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA. Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA. (creator_code:org_t)
Springer Nature, 2023
2023
Engelska.
Ingår i: Scientific Data. - : Springer Nature. - 2052-4463. ; 10
Relaterad länk:
https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Adipogenesis is a process in which fat-specific progenitor cells (preadipocytes) differentiate into adipocytes that carry out the key metabolic functions of the adipose tissue, including glucose uptake, energy storage, and adipokine secretion. Several cell lines are routinely used to study the molecular regulation of adipogenesis, in particular the immortalized mouse 3T3-L1 line and the primary human Simpson-Golabi-Behmel syndrome (SGBS) line. However, the cell-to-cell variability of transcriptional changes prior to and during adipogenesis in these models is not well understood. Here, we present a single-cell RNA-Sequencing (scRNA-Seq) dataset collected before and during adipogenic differentiation of 3T3-L1 and SGBS cells. To minimize the effects of experimental variation, we mixed 3T3-L1 and SGBS cells and used computational analysis to demultiplex transcriptomes of mouse and human cells. In both models, adipogenesis results in the appearance of three cell clusters, corresponding to preadipocytes, early and mature adipocytes. These data provide a groundwork for comparative studies on these widely used in vitro models of human and mouse adipogenesis, and on cell-to-cell variability during this process.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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