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  • Malinovschi, Andrei,1978-Uppsala universitet,Klinisk fysiologi,Uppsala Univ, Sweden (author)

Consequences of Using Post- or Prebronchodilator Reference Values in Interpreting Spirometry

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • American Thoracic Society,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-507832
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-507832URI
  • https://doi.org/10.1164/rccm.202212-2341OCDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217871URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153791699URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-198527URI
  • https://gup.ub.gu.se/publication/335487URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies|Swedish Heart and Lung Foundation; SCAPIS (Swedish CArdioPulmonary bioImage Study); Knut and Alice Wallenberg Foundation; Swedish Research Council; VINNOVA (Swedens Innovation Agency); University of Gothenburg; Sahlgrenska University Hospital; Karolinska Institutet; Karolinska University Hospital; Linkoping University and University Hospital; Lund University; Skane University Hospital; Umea University and University Hospital; Uppsala University and University Hospital; Swedish government; county councils
  • RATIONALE: Post-bronchodilator (BD) spirometry is used for diagnosis of chronic obstructive pulmonary disease (COPD). However, pre-BD reference values are used for spirometry interpretation.OBJECTIVES: To compare the resulting prevalence rates of abnormal spirometry and study the consequences of using pre- or post-BD reference values generated within the Swedish CArdioPulmonary bioImage Study (SCAPIS) when interpreting post-BD spirometry in a general population.METHODS: SCAPIS reference values for post-BD and pre-BD spirometry were based on 10,156 and 1,498 never-smoking, healthy participants, respectively. We studied the associations of abnormal spirometry, defined by using pre- or post-BD reference values, with respiratory burden in the SCAPIS general population (28,851 individuals).MEASUREMENTS AND MAIN RESULTS: Bronchodilation resulted in higher predicted median and lower limit of normal (LLN) for FEV1/FVC ratio. The prevalence of post-BD FEV1/FVC < pre-bronchodilator LLN was 4.8% and that of post-BD FEV1/FVC < post-bronchodilator LLN was 9.9% for the general population. An additional 5.1% was identified as having an abnormal post-BD FEV1/FVC ratio and this group had more respiratory symptoms, emphysema (13.5% vs. 4.1%, p<0.001) and self-reported physician-diagnosed COPD (2.8% vs. 0.5%, p<0.001) than subjects with post-BD FEV1/FVC ratio > LLN for both pre- and post-bronchodilation).CONCLUSIONS: Pre- and post-bronchodilator spirometry reference values differ with regard to FEV1/FVC ratio. Use of post-bronchodilator reference values doubled the population prevalence of airflow obstruction; this was related to a higher respiratory burden. Using post-bronchodilator reference values when interpreting post-bronchodilator spirometry might enable identification of individuals with mild disease and be clinically relevant.

Subject headings and genre

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  • Zhou, XingwuUppsala universitet,Statistiska institutionen,Klinisk fysiologi,Lung- allergi- och sömnforskning,Uppsala Univ, Sweden(Swepub:uu)xinzh435 (author)
  • Andersson, AndersGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition(Swepub:gu)xaandx (author)
  • Backman, HelenaUmeå universitet,Avdelningen för hållbar hälsa,Umea Univ, Sweden(Swepub:umu)heaban01 (author)
  • Bake, Björn,1939Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xbakbj (author)
  • Blomberg, Anders,1961-Umeå universitet,Avdelningen för medicin,Umea Univ, Sweden(Swepub:umu)anbl0001 (author)
  • Caidahl, Kenneth,1949Gothenburg University,Göteborgs universitet,Karolinska Institutet,Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden; Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xcaike (author)
  • Eriksson, Maria J.Karolinska Institutet,Karolinska Inst, Sweden (author)
  • Eriksson Ström, Jonas,1977-Umeå universitet,Avdelningen för medicin,Karolinska Univ Hosp, Sweden(Swepub:umu)joer0101 (author)
  • Hamrefors, ViktorLund Univ, Sweden; Skane Univ Hosp, Sweden (author)
  • Hjelmgren, OlaGothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xhjelo (author)
  • Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning,Uppsala Univ, Sweden(Swepub:uu)chrisjn (author)
  • Karimi, RezaKarolinska Inst, Sweden (author)
  • Kylhammar, DavidLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Fysiologiska kliniken US(Swepub:liu)davky49 (author)
  • Lindberg, AnneUmeå universitet,Avdelningen för medicin,Umea Univ, Sweden(Swepub:umu)anelig02 (author)
  • Lindberg, EvaUppsala universitet,Lung- allergi- och sömnforskning,Uppsala Univ, Sweden(Swepub:uu)evalb (author)
  • Liv, PerUmea Univ, Sweden (author)
  • Olin, Anna-Carin,1960Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xolina (author)
  • Shalabi, AdelKarolinska Inst, Sweden (author)
  • Sköld, C. MagnusKarolinska Univ Hosp, Sweden (author)
  • Sundström, Johan,Professor,1971-Uppsala universitet,Klinisk epidemiologi,The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia,Uppsala Univ, Sweden; Univ New South Wales, Australia(Swepub:uu)johasund (author)
  • Tanash, HananLund Univ, Sweden (author)
  • Torén, Kjell,1952Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xtorkj (author)
  • Wollmer, PerLund Univ, Sweden (author)
  • Zaigham, SuneelaUppsala universitet,Klinisk fysiologi,Department of Clinical Sciences, Lund University, Malmö, Sweden,Uppsala Univ, Sweden(Swepub:uu)sunza471 (author)
  • Östgren, Carl JohanLinköpings universitet,Avdelningen för prevention, rehabilitering och nära vård,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Vårdcentralen Ekholmen(Swepub:liu)caros18 (author)
  • Engvall, JanLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Fysiologiska kliniken US(Swepub:liu)janen74 (author)
  • Uppsala universitetKlinisk fysiologi (creator_code:org_t)

Related titles

  • In:American Journal of Respiratory and Critical Care Medicine: American Thoracic Society208:4, s. 461-4711073-449X1535-4970

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