Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study

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Zhang, HanZhengzhou Univ, Henan Prov Peoples Hosp, Zhengzhou, Peoples R China.;Zhengzhou Univ, Coll Publ Hlth, Zhengzhou, Peoples R China. (author)

Atopic dermatitis and chronic kidney disease : a bidirectional Mendelian randomization study

Article/chapterEnglish2023

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Frontiers Media SA,2023
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LIBRIS-ID:oai:DiVA.org:uu-508422
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-508422URI
https://doi.org/10.3389/fmed.2023.1180596DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:153139070URI

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Language:English
Summary in:English

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Background: A bidirectional association between atopic dermatitis and chronic kidney disease (CKD) has been revealed in observational studies, whereas the causality of this association was unclear. We conducted a Mendelian randomization study to determine the bidirectional causal association between atopic dermatitis and CKD.Methods: Independent genetic instruments associated with atopic dermatitis and CKD at the genome-wide significance level were chosen from corresponding meta-analyses of genome-wide association studies. Summary-level data for atopic dermatitis were obtained from the EAGLE Eczema consortium (30,047 cases and 40,835 controls) and FinnGen consortium (7,024 cases and 198,740 controls). Summary-level data for CKD were derived from CKDGen consortium (64,164 cases and 625,219 controls) and FinnGen consortium (3,902 cases and 212,841 controls). The inverse-variance weighted method was used in the main analysis and supplemented with three sensitivity analyses.Results: Genetic predisposition to atopic dermatitis was associated with an increased risk of CKD. For a one-unit increase in the prevalence of atopic dermatitis, the odds ratio of CKD was 1.07 (95% confidence interval: 1.01-1.12). In the reverse Mendelian randomization analysis, the odds ratio of atopic dermatitis was 1.14 (95% confidence interval: 1.03-1.26) for a one-unit increase in the prevalence of CKD. The associations persisted in sensitivity analyses and no pleiotropy was detected.Conclusion: This Mendelian randomization study suggests a bidirectional positive association between atopic dermatitis and CKD.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Dermatologi och venereologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Dermatology and Venereal Diseases hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
atopic dermatitis
chronic kidney disease
Mendelian randomization
MR-PRESSO
bidirectional Mendelian randomization

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Yuan, ShuaiKarolinska Institutet (author)
Li, YongUniv Freiburg, Inst Genet Epidemiol Epidemiol & Med Bioinformat, Fac Med, Dept Biometry, Freiburg, Germany.;Univ Freiburg, Med Ctr, Freiburg, Germany. (author)
Li, DoudouZhengzhou Univ, Coll Publ Hlth, Zhengzhou, Peoples R China. (author)
Yu, ZengliZhengzhou Univ, Coll Publ Hlth, Zhengzhou, Peoples R China.;NHC Key Lab Birth Defects Prevent, Zhengzhou, Peoples R China.;Henan Key Lab Populat Defects Prevent, Zhengzhou, Peoples R China. (author)
Hu, LidanZhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Sch Med, Hangzhou, Peoples R China. (author)
Li, XueZhengzhou Univ, Henan Prov Peoples Hosp, Zhengzhou, Peoples R China. (author)
Wang, YumingZhengzhou Univ, Henan Prov Peoples Hosp, Zhengzhou, Peoples R China. (author)
Larsson, Susanna C.Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.(Swepub:uu)susla720 (author)
Karolinska InstitutetZhengzhou Univ, Henan Prov Peoples Hosp, Zhengzhou, Peoples R China.;Zhengzhou Univ, Coll Publ Hlth, Zhengzhou, Peoples R China. (creator_code:org_t)

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dermatology and ...

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