Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta-Analysis of 20 Prospective Studies

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Tschiderer, LenaMed Univ Innsbruck, Inst Hlth Econ, Innsbruck, Austria. (author)

Association of Intima-Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque : Individual Participant Data Meta-Analysis of 20 Prospective Studies

Article/chapterEnglish2023

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Ovid Technologies (Wolters Kluwer Health),2023
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LIBRIS-ID:oai:DiVA.org:uu-508586
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-508586URI
https://doi.org/10.1161/JAHA.122.027657DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:153141183URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Background: The association between common carotid artery intima-media thickness (CCA-IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA-IMT and carotid plaque development.Methods and Results: We undertook an individual participant data meta-analysis of 20 prospective studies from the Proof-ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA-IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA-IMT was 0.71 mm (SD, 0.17 mm). Over a median follow-up of 5.9 years (5th-95th percentile, 1.9-19.0 years), 8278 individuals developed first-ever carotid plaque. We combined study-specific odds ratios (ORs) for incident carotid plaque using random-effects meta-analysis. Baseline CCA-IMT was approximately log-linearly associated with the odds of developing carotid plaque. The age-, sex-, and trial arm-adjusted OR for carotid plaque per SD higher baseline CCA-IMT was 1.40 (95% CI, 1.31-1.50; I-2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low- and high-density lipoprotein cholesterol, and lipid-lowering and antihypertensive medication was 1.34 (95% CI, 1.24-1.45; I-2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29-1.47]; I-2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques).Conclusions: Our large-scale individual participant data meta-analysis demonstrated that CCA-IMT is associated with the long-term risk of developing first-ever carotid plaque, independent of traditional cardiovascular risk factors.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
carotid intima-media thickness
carotid plaque
individual participant data meta-analysis
prospective studies

Added entries (persons, corporate bodies, meetings, titles ...)

Seekircher, LisaMed Univ Innsbruck, Inst Hlth Econ, Innsbruck, Austria. (author)
Izzo, RaffaeleUniv Naples Federico II, Dept Adv Biomed Sci, Naples, Italy. (author)
Mancusi, Costantino V.Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy. (author)
Manzi, MariaUniv Naples Federico II, Dept Adv Biomed Sci, Naples, Italy.,Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands. (author)
Baldassarre, DamianoUniv Milan, Dept Med Biotechnol & Translat Med, Milan, Italy.;Ctr Cardiol Monzino Stituto Ricovero & Cura & Cara, Milan, Italy. (author)
Amato, MauroCtr Cardiol Monzino Stituto Ricovero & Cura & Cara, Milan, Italy. (author)
Tremoli, ElenaMaria Cecilia Hosp, Cotignola, Ravenna, Italy. (author)
Veglia, FabrizioMaria Cecilia Hosp, Cotignola, Ravenna, Italy. (author)
Tuomainen, Tomi-PekkaUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland. (author)
Kauhanen, JussiUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland. (author)
Voutilainen, AriUniv Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland. (author)
Iglseder, BernhardGemeinnutzige Salzburger Landeskliniken Betriebsge, Dept Geriatr Med, Salzburg, Austria.;Paracelsus Med Univ, Dept Geriatr Med, Salzburg, Austria. (author)
Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper,Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.(Swepub:uu)larslind (author)
Rundek, TatjanaUniv Miami Miller, Dept Neurol, Sch Med, Miami, FL USA. (author)
Desvarieux, MoiseColumbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.;Inst Natl Sante & Rech Med Unite Mixte Rech 1153, Ctr Rech Epidemiol & Stat Paris Sorbonne Cite, METHODS Core, Paris, France. (author)
Kato, AkihikoHamamatsu Univ Hosp, Blood Purificat Unit, Hamamatsu, Japan. (author)
de Groot, EricImagelabonline & Cardiovasc, Erichem, Netherlands.;Amsterdam Univ Med Ctr, Acad Med Ctr, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands. (author)
Asci, GuelayEge Univ, Nephrol Dept, Sch Med, Bornova, Izmir, Turkiye. (author)
Ok, ErcanEge Univ, Nephrol Dept, Sch Med, Bornova, Izmir, Turkiye. (author)
Agewall, StefanKarolinska Institutet,Univ Oslo, Inst Clin Sci, Oslo, Norway.;Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Div Cardiol, Stockholm, Sweden. (author)
Beulens, Joline W. J. D.Vrije Univ Med Ctr, Amsterdam Univ Med Ctr, Dept Epidemiol & Data Sci, Amsterdam, Netherlands. (author)
Byrne, Christopher C.Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton, England.;Univ Hosp Southampton, Southampton Natl Inst Hlth & Care Res, Biomed Res Ctr, Southampton, England. (author)
Calder, Philip C.Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton, England.;Univ Hosp Southampton, Southampton Natl Inst Hlth & Care Res, Biomed Res Ctr, Southampton, England. (author)
Gerstein, HertzelMcMaster Univ, Dept Med & Populat Hlth, Res Inst, Hamilton, ON, Canada.;Hamilton Gen Hosp, Hamilton, ON, Canada. (author)
Gresele, PaoloUniv Perugia, Dept Med & Surg, Div Internal & Cardiovasc Med, Perugia, Italy. (author)
Klingenschmid, GerhardMed Univ Innsbruck, Dept Neurol, Innsbruck, Austria. (author)
Nagai, Michiaki H.Hiroshima City Asa Hosp, Dept Internal Med Gen Med & Cardiol, Hiroshima, Japan. (author)
Olsen, MichaelUniv Southern Denmark, Holbaek Hosp, Dept Internal Med, Odense, Denmark. (author)
Parraga, Grace S.Western Univ, Robarts Res Inst, Dept Med Biophys, London, ON, Canada. (author)
Safarova, MayaUniv Kansas Med Ctr, Dept Cardiovasc Med, Kansas City, KS USA.;Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Sydney, NSW, Australia. (author)
Sattar, NaveedUniv Glasgow, British Heart Fdn Glasgow Cardiovasc Res Ctr, Glasgow, Scotland. (author)
Skilton, Michael (author)
Stehouwer, Coen D. A.Maastricht Univ Med Ctr, Cardiovasc Res Inst Maastricht, Dept Internal Med, Maastricht, Netherlands. (author)
Uthoff, Heiko A.Univ Hosp Basel, Dept Angiol, Basel, Switzerland. (author)
van Agtmael, Michiel A.Amsterdam Univ Med Ctr, Vrije Univ, Dept Internal Med, Amsterdam, Netherlands. (author)
van der Heijden, Amber A.Vrije Univ Med Ctr, Amsterdam Univ Med Ctr, Dept Gen Practice, Amsterdam, Netherlands. (author)
Zozulinska-Ziolkiewicz, DorotaPoznan Univ Med Sci, Dept Internal Med & Diabetol, Poznan, Poland. (author)
Park, Hyun-WoongChungnam Natl Univ, Sejong Hosp, Dept Internal Med, Div Cardiol, Sejong Si, South Korea. (author)
Lee, Moo-SikKonyang Univ, Coll Med, Dept Prevent Med, Daejeon, South Korea.;Konyang Univ Hosp, Dept Occupat & Environm Med, Daejeon, South Korea. (author)
Bae, Jang-HoKonyang Univ Hosp, Heart Ctr, Daejeon, South Korea. (author)
Beloqui, Oscar F.Univ Clin Navarra, Dept Internal Med, Navarra, Spain. (author)
Landecho, ManuelUniv Clin Navarra, Dept Internal Med, Navarra, Spain. (author)
Plichart, MatthieuUniv Paris 05, Paris Cardiovasc Res Ctr, Paris, France. (author)
Ducimetiere, PierreHosp Home, Fdn St Serv, Levallois Perret, France. (author)
Empana, Jean PhilippeUniv Paris 05, Paris Cardiovasc Res Ctr, Paris, France. (author)
Bokemark, LenaUniv Gothenburg, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden. (author)
Bergstroem, GoeranUniv Gothenburg, Inst Med, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden. (author)
Schmidt, CarolineUniv Gothenburg, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden. (author)
Castelnuovo, SamuelaAziende Socio Sanitarie Territoriali Grande Osped, Ctr Dislipidemie, Milan, Italy. (author)
Calabresi, Laura D.Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy.;Stituto Ricovero & Cura Carattere Sci Multimed, Milan, Italy. (author)
Norata, GiuseppeUniv Milan, Dept Pharmacol & Biomol Sci, Milan, Italy.;Bassini Hosp, Soc Italiana Studio Aterosclerosi Ctr Study Athero, Cinisello Balsamo, Italy. (author)
Grigore, Liliana (author)
Catapano, AlbericoUniv Milan, Dept Pharmacol & Biomol Sci, Milan, Italy.;Stituto Ricovero & Cura Carattere Sci Multimed, Milan, Italy. (author)
Zhao, DongCapital Med Univ, Beijing Anzhen Hosp, Dept Epidemiol, Beijing, Peoples R China. (author)
Wang, MiaoCapital Med Univ, Beijing Anzhen Hosp, Dept Epidemiol, Beijing, Peoples R China. (author)
Liu, JingCapital Med Univ, Beijing Anzhen Hosp, Dept Epidemiol, Beijing, Peoples R China. (author)
Ikram, M. ArfanErasmus MC, Dept Epidemiol, Rotterdam, Netherlands. (author)
Kavousi, Maryam L.Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands. (author)
Bots, Michiel J.Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (author)
Sweeting, Michael W.Univ Leicester, Dept Hlth Sci, Leicester, England.;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England. (author)
Lorenz, MatthiasGoethe Univ, Dept Neurol, Frankfurt, Germany.;Krankenhaus NW Frankfurt, Klin Neurol, Frankfurt, Germany. (author)
Willeit, PeterMed Univ Innsbruck, Inst Hlth Econ, Innsbruck, Austria.;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.;Med Univ Innsbruck, Anichstr 35, A-6020 Innsbruck, Austria. (author)
Med Univ Innsbruck, Inst Hlth Econ, Innsbruck, Austria.Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy. (creator_code:org_t)

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By the author/editor: Tschiderer, Lena; Seekircher, Lisa; Izzo, Raffaele; Mancusi, Costant ...; Manzi, Maria; Baldassarre, Dam ...; show more...; Amato, Mauro; Tremoli, Elena; Veglia, Fabrizio; Tuomainen, Tomi- ...; Kauhanen, Jussi; Voutilainen, Ari; Iglseder, Bernha ...; Lind, Lars; Rundek, Tatjana; Desvarieux, Mois ...; Kato, Akihiko; de Groot, Eric; Asci, Guelay; Ok, Ercan; Agewall, Stefan; Beulens, Joline ...; Byrne, Christoph ...; Calder, Philip C ...; Gerstein, Hertze ...; Gresele, Paolo; Klingenschmid, G ...; Nagai, Michiaki ...; Olsen, Michael; Parraga, Grace S ...; Safarova, Maya; Sattar, Naveed; Skilton, Michael; Stehouwer, Coen ...; Uthoff, Heiko A.; van Agtmael, Mic ...; van der Heijden, ...; Zozulinska-Ziolk ...; Park, Hyun-Woong; Lee, Moo-Sik; Bae, Jang-Ho; Beloqui, Oscar F ...; Landecho, Manuel; Plichart, Matthi ...; Ducimetiere, Pie ...; Empana, Jean Phi ...; Bokemark, Lena; Bergstroem, Goer ...; Schmidt, Carolin ...; Castelnuovo, Sam ...; Calabresi, Laura ...; Norata, Giuseppe; Grigore, Liliana; Catapano, Alberi ...; Zhao, Dong; Wang, Miao; Liu, Jing; Ikram, M. Arfan; Kavousi, Maryam ...; Bots, Michiel J.; Sweeting, Michae ...; Lorenz, Matthias; Willeit, Peter; show less...

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