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Fibromyalgia patien...
Fibromyalgia patients with elevated levels of anti-satellite glia cell immunoglobulin G antibodies present with more severe symptoms
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- Krock, Emerson (författare)
- Karolinska Institutet
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- Morado-Urbina, Carlos E. (författare)
- Karolinska Institutet
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- Menezes, Joana (författare)
- Karolinska Inst, Ctr Mol Med, Dept Physiol & Pharmacol, Stockholm, Sweden.
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- Hunt, Matthew A. (författare)
- Karolinska Inst, Ctr Mol Med, Dept Physiol & Pharmacol, Stockholm, Sweden.
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- Sandstroem, Angelica (författare)
- Karolinska Institutet
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- Kadetoff, Diana (författare)
- Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
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- Tour, Jeanette (författare)
- Karolinska Institutet
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- Verma, Vivek (författare)
- McGill Univ, Fac Dent Med & Oral Hlth Sci, Fac Med & Hlth Sci,Dept Anesthesia, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada.
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- Kultima, Kim (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Haglund, Lisbet (författare)
- McGill Univ, Dept Surg, Div Orthopaed Surg, Montreal, PQ, Canada.
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- Meloto, Carolina B. (författare)
- McGill Univ, Fac Dent Med & Oral Hlth Sci, Fac Med & Hlth Sci,Dept Anesthesia, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada.
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- Diatchenko, Luda (författare)
- McGill Univ, Fac Dent Med & Oral Hlth Sci, Fac Med & Hlth Sci,Dept Anesthesia, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada.
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- Kosek, Eva (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk smärtforskning,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
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- Svensson, Camilla I. (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Ctr Mol Med, Dept Physiol & Pharmacol, Stockholm, Sweden (creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2023
- 2023
- Engelska.
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Ingår i: Pain. - : Ovid Technologies (Wolters Kluwer Health). - 0304-3959 .- 1872-6623. ; 164:8, s. 1828-1840
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Transferring fibromyalgia patient immunoglobulin G (IgG) to mice induces pain-like behaviour, and fibromyalgia IgG binds mouse and human satellite glia cells (SGCs). These findings suggest that autoantibodies could be part of fibromyalgia pathology. However, it is unknown how frequently fibromyalgia patients have anti-SGC antibodies and how anti-SGC antibodies associate with disease severity. Here, we quantified serum or plasma anti-SGC IgG levels in 2 fibromyalgia cohorts from Sweden and Canada using an indirect immunofluorescence murine cell culture assay. Fibromyalgia serum IgG binding to human SGCs in human dorsal root ganglia tissue sections was also assessed by immunofluorescence. In the cell culture assay, anti-SGC IgG levels were increased in both fibromyalgia cohorts compared with control group. Elevated anti-SGC IgG was associated with higher levels of self-reported pain in both cohorts, and higher fibromyalgia impact questionnaire scores and increased pressure sensitivity in the Swedish cohort. Anti-SGC IgG levels were not associated with fibromyalgia duration. Swedish fibromyalgia (FM) patients were clustered into FM-severe and FM-mild groups, and the FM-severe group had elevated anti-SGC IgG compared with the FM-mild group and control group. Anti-SGC IgG levels detected in culture positively correlated with increased binding to human SGCs. Moreover, the FM-severe group had elevated IgG binding to human SGCs compared with the FM-mild and control groups. These results demonstrate that a subset of fibromyalgia patients have elevated levels of anti-SGC antibodies, and the antibodies are associated with more severe fibromyalgia symptoms. Screening fibromyalgia patients for anti-SGC antibodies could provide a path to personalized treatment options that target autoantibodies and autoantibody production.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Autoimmunity
- Autoantibodies
- Dorsal root ganglia
- Fibromyalgia
- Satellite glia cells
- Neuron
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Krock, Emerson
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Morado-Urbina, C ...
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Menezes, Joana
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Hunt, Matthew A.
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Sandstroem, Ange ...
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Kadetoff, Diana
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visa fler...
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Tour, Jeanette
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Verma, Vivek
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Kultima, Kim
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Haglund, Lisbet
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Meloto, Carolina ...
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Diatchenko, Luda
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Kosek, Eva
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Svensson, Camill ...
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