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  • Krock, EmersonKarolinska Institutet (författare)

Fibromyalgia patients with elevated levels of anti-satellite glia cell immunoglobulin G antibodies present with more severe symptoms

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Ovid Technologies (Wolters Kluwer Health),2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-508850
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-508850URI
  • https://doi.org/10.1097/j.pain.0000000000002881DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153311384URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Transferring fibromyalgia patient immunoglobulin G (IgG) to mice induces pain-like behaviour, and fibromyalgia IgG binds mouse and human satellite glia cells (SGCs). These findings suggest that autoantibodies could be part of fibromyalgia pathology. However, it is unknown how frequently fibromyalgia patients have anti-SGC antibodies and how anti-SGC antibodies associate with disease severity. Here, we quantified serum or plasma anti-SGC IgG levels in 2 fibromyalgia cohorts from Sweden and Canada using an indirect immunofluorescence murine cell culture assay. Fibromyalgia serum IgG binding to human SGCs in human dorsal root ganglia tissue sections was also assessed by immunofluorescence. In the cell culture assay, anti-SGC IgG levels were increased in both fibromyalgia cohorts compared with control group. Elevated anti-SGC IgG was associated with higher levels of self-reported pain in both cohorts, and higher fibromyalgia impact questionnaire scores and increased pressure sensitivity in the Swedish cohort. Anti-SGC IgG levels were not associated with fibromyalgia duration. Swedish fibromyalgia (FM) patients were clustered into FM-severe and FM-mild groups, and the FM-severe group had elevated anti-SGC IgG compared with the FM-mild group and control group. Anti-SGC IgG levels detected in culture positively correlated with increased binding to human SGCs. Moreover, the FM-severe group had elevated IgG binding to human SGCs compared with the FM-mild and control groups. These results demonstrate that a subset of fibromyalgia patients have elevated levels of anti-SGC antibodies, and the antibodies are associated with more severe fibromyalgia symptoms. Screening fibromyalgia patients for anti-SGC antibodies could provide a path to personalized treatment options that target autoantibodies and autoantibody production.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Morado-Urbina, Carlos E.Karolinska Institutet (författare)
  • Menezes, JoanaKarolinska Inst, Ctr Mol Med, Dept Physiol & Pharmacol, Stockholm, Sweden. (författare)
  • Hunt, Matthew A.Karolinska Inst, Ctr Mol Med, Dept Physiol & Pharmacol, Stockholm, Sweden. (författare)
  • Sandstroem, AngelicaKarolinska Institutet (författare)
  • Kadetoff, DianaKarolinska Inst, Dept Clin Neurosci, Stockholm, Sweden. (författare)
  • Tour, JeanetteKarolinska Institutet (författare)
  • Verma, VivekMcGill Univ, Fac Dent Med & Oral Hlth Sci, Fac Med & Hlth Sci,Dept Anesthesia, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada. (författare)
  • Kultima, KimUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)kikul535 (författare)
  • Haglund, LisbetMcGill Univ, Dept Surg, Div Orthopaed Surg, Montreal, PQ, Canada. (författare)
  • Meloto, Carolina B.McGill Univ, Fac Dent Med & Oral Hlth Sci, Fac Med & Hlth Sci,Dept Anesthesia, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada. (författare)
  • Diatchenko, LudaMcGill Univ, Fac Dent Med & Oral Hlth Sci, Fac Med & Hlth Sci,Dept Anesthesia, Alan Edwards Ctr Res Pain, Montreal, PQ, Canada. (författare)
  • Kosek, EvaKarolinska Institutet,Uppsala universitet,Klinisk smärtforskning,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.(Swepub:uu)evako353 (författare)
  • Svensson, Camilla I.Karolinska Institutet (författare)
  • Karolinska InstitutetKarolinska Inst, Ctr Mol Med, Dept Physiol & Pharmacol, Stockholm, Sweden. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Pain: Ovid Technologies (Wolters Kluwer Health)164:8, s. 1828-18400304-39591872-6623

Internetlänk

Hitta via bibliotek

  • Pain (Sök värdpublikationen i LIBRIS)

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