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Variability in whit...
Variability in white blood cell count during uncomplicated malaria and implications for parasite density estimation : a WorldWide Antimalarial Resistance Network individual patient data meta-analysis
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- Wynberg, Elke (författare)
- Publ Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands.
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- Commons, Robert J. (författare)
- WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia.;Grampians Hlth, Gen & Subspecialty Med, Ballarat, Vic, Australia.
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- Humphreys, Georgina (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.
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visa fler...
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- Ashurst, Hazel (författare)
- WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.
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- Burrow, Rebekah (författare)
- WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.
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- Adjei, George O. (författare)
- Univ Ghana, Ctr Trop Clin Pharmacol & Therapeut, Sch Med, Accra, Ghana.
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- Adjuik, Martin (författare)
- Navrongo Hlth Res Ctr, Navrongo, Ghana.;INDEPTH NETWORK Secretariat, Accra, Ghana.
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- Anstey, Nicholas M. (författare)
- Menzies Sch Hlth Res, Global Hlth Div, Darwin, NT, Australia.;Charles Darwin Univ, Darwin, NT, Australia.
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- Anvikar, Anup (författare)
- Natl Inst Malaria Res, New Delhi, India.
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- Baird, Kevin J. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Eijkman Oxford Clin Res Unit, Jakarta, Indonesia.
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- Barber, Bridget E. (författare)
- Menzies Sch Hlth Res, Global Hlth Div, Darwin, NT, Australia.;Charles Darwin Univ, Darwin, NT, Australia.;Menzies Sch Hlth Res, Infect Dis Soc Sabah, Clin Res Unit, Kota Kinabalu, Sabah, Malaysia.
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- Barennes, Hubert (författare)
- Agence Natl Rech Sida ANRS, Bobo Dioulasso, Burkina Faso.;Unite Epidemiol Intervent Ctr Muraz, Bobo Dioulasso, Burkina Faso.;Inst Francophone Med Trop, Vientiane Lao Pdr, Laos.
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- Baudin, Elisabeth (författare)
- Epicentre, Paris, France.
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- Bell, David J. (författare)
- Univ Liverpool Liverpool Sch Trop Med, Liverpool, England.;Malawi Liverpool Wellcome Clin Res Programme, Bangkok, Thailand.;Malawi Liverpool Wellcome Clin Res Programme, Liverpool, England.
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- Bethell, Delia (författare)
- US Army Med Component Armed Forces Res Inst Med, Bangkok, Thailand.
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- Binh, Tran Quang (författare)
- Cho Ray Hosp, Dept Trop Dis, Ho Chi Minh City, Vietnam.
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- Borghini, Isabelle (författare)
- Fuhrer, Med Malaria Venture, Geneva, Switzerland.
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- Chu, Cindy S. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahidol Univ, Fac Trop Med, Dept Med,Mahidol Oxford Trop Med Res Unit, Shoklo Malaria Res Unit, Mae Sot, Thailand.
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- Daher, Andre (författare)
- Oswaldo Cruz Fdn FIOCRUZ, Inst Drug Technol Farmanguinhos, Rio De Janeiro, Brazil.;Oswaldo Cruz Fdn FIOCRUZ, Res & Reference Labs, Rio De Janeiro, Brazil.;Univ Liverpool Liverpool Sch Trop Med, Liverpool, England.
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- D'Alessandro, Umberto (författare)
- London Sch Hyg & Trop Med, MRC Unit Gambia, London, England.
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- Das, Debashish (författare)
- WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit MORU, Bangkok, Thailand.
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- Davis, Timothy Me (författare)
- Univ Western Australia, Sch Med & Pharmacol, Crawley, WA, Australia.
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- de Vries, Peter J. (författare)
- Tergooi Hosp, Dept Internal Med, Hilversum, Netherlands.
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- Djimde, Abdoulaye A. (författare)
- Univ Sci Techn & Technol Bamako, Fac Pharm, Malaria Res & Training Ctr, Bamako, Mali.
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- Dondorp, Arjen M. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit MORU, Bangkok, Thailand.
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- Dorsey, Grant (författare)
- Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
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- Faucher, Jean-Francois F. (författare)
- CHU Limoges, Serv Malad infect & Trop, Limoges, France.;INSERM, EpiMaCT Epidemiol Chron Dis Trop Zone, U1094, Limoges, France.;Limoges Univ Hosp, Infect Dis & Trop Med Dept, Limoges, France.
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- Fogg, Carole (författare)
- Epicentre, Paris, France.;Univ Southampton, Southampton, England.
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- Gaye, Oumar (författare)
- Univ Cheikh Anta Diop, Dept Med Parasitol, Fac Med, Dakar, Senegal.
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- Grigg, Matthew (författare)
- Menzies Sch Hlth Res, Global Hlth Div, Darwin, NT, Australia.;Charles Darwin Univ, Darwin, NT, Australia.
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- Hatz, Christoph (författare)
- Swiss Trop & Publ Hlth Inst, Allschwil, Switzerland.;Univ Basel, Basel, Switzerland.
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- Kager, Piet A. (författare)
- Ctr Infect & Immun Amsterdam CINEMA, Acad Med Ctr, Div Infect Dis Trop Med & AIDS, Amsterdam, Netherlands.
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- Lacerda, Marcus (författare)
- Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Brazil.;Inst Leonidas & Maria Deane, Fiocruz, Brazil.
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- Laman, Moses (författare)
- Univ Western Australia, Sch Med & Pharmacol, Fremantle Hosp, Fremantle, WA, Australia.;Papua New Guinea Inst Med Res, Madang, Papua N Guinea.
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- Mårtensson, Andreas, 1963- (författare)
- Uppsala universitet,Internationell barnhälsa och nutrition
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- Menan, Herve Ignace Eby (författare)
- Univ Cocody, Dept Parasitol, Fac Pharm, Abidjan, Cote Ivoire.
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- Monteiro, Wuelton M. (författare)
- Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Brazil.;Univ Estado Amazonas, Manaus, Brazil.
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- Moore, Brioni R. (författare)
- Curtin Univ, Curtin Med Sch, Perth, Australia.;Fremantle Hosp, Fremantle, WA, Australia.
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- Nosten, Francois (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahidol Univ, Fac Trop Med, Dept Med,Mahidol Oxford Trop Med Res Unit, Shoklo Malaria Res Unit, Mae Sot, Thailand.
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- Ogutu, Bernhards (författare)
- US Army Med Res Unit, Kenya Med Res Inst, Clin Res Ctr, Kisumu, Kenya.
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- Osorio, Lyda (författare)
- CIDEIM Int Ctr Med Res & Training, Cali, Colombia.
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- Penali, Louis K. (författare)
- Inst Pasteur, Malariol Dept, Abidjan, Cote Ivoire.
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- Pereira, Dhelio B. (författare)
- Ctr Pesquisa Med Trop Rondonia CEPEM, Porto Velho, Rondonia, Brazil.;Univ Fed Rondonia UNIR, Porto Velho, Rondonia, Brazil.
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- Rahim, Awab G. (författare)
- Nangarhar Univ, Fac Med, Jalalabad, Afghanistan.;MORU Trop Hlth Network, Bangkok, Thailand.
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- Ramharter, Michael (författare)
- Univ Med Ctr Hamburg Eppendorf, Bernhard Nocht Inst Trop Med, Dept Trop Med, Hamburg, Germany.;Univ Med Ctr Hamburg Eppendorf, Dept Med 1, Hamburg, Germany.
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- Sagara, Issaka (författare)
- Univ Bamako, Dept Epidemiol Parasit Dis, Malaria Res & Training Ctr, Fac Med Pharm & Odontostomatol, Bamako, Mali.
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- Schramm, Birgit (författare)
- Epicentre, Paris, France.
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- Seidlein, Lorenz (författare)
- Mahidol Univ, Gambia & Mahidol Oxford Univ Res Unit MORU, Med Res Council Labs, Farafenni Field Stn, Bangkok, Thailand.
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- Siqueira, Andre M. (författare)
- Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Brazil.;Univ Estado Amazonas, Programa Posgrad Med Trop, Manaus, Brazil.;Fundacao Oswaldo Cruz, Inst Nacl Infectol Evandro Chagas, Rio De Janeiro, Brazil.
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- Sirima, Sodiomon B. (författare)
- Groupe Rech Act Sante GRAS, Ouagadougou, Burkina Faso.
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- Starzengruber, Peter (författare)
- Med Univ Vienna, Inst Specif Prophylaxis & Trop Med, Vienna, Austria.;Med Univ Vienna, Div Clin Microbiol, Dept Lab Med, Vienna, Austria.
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- Sutanto, Inge (författare)
- Univ Indonesia, Dept Parasitol, Fac Med, Jakarta, Indonesia.
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- Taylor, Walter R. (författare)
- Mahidol Univ, Mahidol Oxford Trop Med Res Unit MORU, Bangkok, Thailand.
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- Toure, Offianan A. (författare)
- Inst Pasteur, Malariol Dept, Abidjan, Cote Ivoire.
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- Utzinger, Jurg (författare)
- Swiss Trop & Publ Hlth Inst, Allschwil, Switzerland.;Univ Basel, Basel, Switzerland.
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- Valea, Innocent (författare)
- Ctr Muraz, Unite Rech Paludisme & Malad Trop Negligees, Bobo Dioulasso, Burkina Faso.;Unite Rech Clin Nanoro, Inst Rech Sci Sante, Nanoro, Burkina Faso.
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- Valentini, Giovanni (författare)
- Alfasigma SpA, Dept Res & Dev, Bologna, Italy.
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- White, Nicholas J. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit MORU, Bangkok, Thailand.
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- William, Timothy (författare)
- Menzies Sch Hlth Res, Infect Dis Soc Sabah, Clin Res Unit, Kota Kinabalu, Sabah, Malaysia.;Gleneagles Hosp, Kota Kinabalu, Sabah, Malaysia.
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- Woodrow, Charles J. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit MORU, Bangkok, Thailand.
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- Richmond, Caitlin L. (författare)
- WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.
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- Guerin, Philippe J. (författare)
- WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.
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- Price, Ric N. (författare)
- Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.;Charles Darwin Univ, Global & Trop Hlth Div, Menzies Sch Hlth Res, Darwin, Australia.
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- Stepniewska, Kasia (författare)
- WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England.
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Publ Hlth Serv Amsterdam, Dept Infect Dis, Amsterdam, Netherlands WorldWide Antimalarial Resistance Network WWARN, Oxford, England.;Charles Darwin Univ, Menzies Sch Hlth Res, Global & Trop Hlth Div, Darwin, NT, Australia.;Grampians Hlth, Gen & Subspecialty Med, Ballarat, Vic, Australia. (creator_code:org_t)
- Springer Nature, 2023
- 2023
- Engelska.
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Ingår i: Malaria Journal. - : Springer Nature. - 1475-2875. ; 22
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: The World Health Organization (WHO) recommends that when peripheral malarial parasitaemia is quantified by thick film microscopy, an actual white blood cell (WBC) count from a concurrently collected blood sample is used in calculations. However, in resource-limited settings an assumed WBC count is often used instead. The aim of this study was to describe the variability in WBC count during acute uncomplicated malaria, and estimate the impact of using an assumed value of WBC on estimates of parasite density and clearance.Methods: Uncomplicated malaria drug efficacy studies that measured WBC count were selected from the WorldWide Antimalarial Resistance Network data repository for an individual patient data meta-analysis of WBC counts. Regression models with random intercepts for study-site were used to assess WBC count variability at presentation and during follow-up. Inflation factors for parasitaemia density, and clearance estimates were calculated for methods using assumed WBC counts (8000 cells/mu L and age-stratified values) using estimates derived from the measured WBC value as reference.Results: Eighty-four studies enrolling 27,656 patients with clinically uncomplicated malaria were included. Geometric mean WBC counts (x 1000 cells/mu L) in age groups < 1, 1-4, 5-14 and >= 15 years were 10.5, 8.3, 7.1, 5.7 and 7.5, 7.0, 6.5, 6.0 for individuals with falciparum (n = 24,978) and vivax (n = 2678) malaria, respectively. At presentation, higher WBC counts were seen among patients with higher parasitaemia, severe anaemia and, for individuals with vivax malaria, in regions with shorter regional relapse periodicity. Among falciparum malaria patients, using an assumed WBC count of 8000 cells/mu L resulted in parasite density underestimation by a median (IQR) of 26% (4-41%) in infants < 1 year old but an overestimation by 50% (16-91%) in adults aged = 15 years. Use of age-stratified assumed WBC values removed systematic bias but did not improve precision of parasitaemia estimation. Imprecision of parasite clearance estimates was only affected by the within-patient WBC variability over time, and remained < 10% for 79% of patients.Conclusions: Using an assumed WBC value for parasite density estimation from a thick smear may lead to underdiagnosis of hyperparasitaemia and could adversely affect clinical management; but does not result in clinically consequential inaccuracies in the estimation of the prevalence of prolonged parasite clearance and artemisinin resistance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Malaria
- White blood cell
- Leukocyte
- Parasitaemia
- Microscopy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Wynberg, Elke
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Commons, Robert ...
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Humphreys, Georg ...
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Ashurst, Hazel
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Burrow, Rebekah
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Adjei, George O.
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visa fler...
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Adjuik, Martin
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Anstey, Nicholas ...
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Anvikar, Anup
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Baird, Kevin J.
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Barber, Bridget ...
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Barennes, Hubert
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Baudin, Elisabet ...
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Bell, David J.
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Bethell, Delia
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Binh, Tran Quang
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Borghini, Isabel ...
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Chu, Cindy S.
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Daher, Andre
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D'Alessandro, Um ...
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Das, Debashish
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Davis, Timothy M ...
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de Vries, Peter ...
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Djimde, Abdoulay ...
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Dondorp, Arjen M ...
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Dorsey, Grant
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Faucher, Jean-Fr ...
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Fogg, Carole
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Gaye, Oumar
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Grigg, Matthew
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Hatz, Christoph
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Kager, Piet A.
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Lacerda, Marcus
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Laman, Moses
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Mårtensson, Andr ...
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Menan, Herve Ign ...
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Monteiro, Wuelto ...
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Moore, Brioni R.
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Nosten, Francois
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Ogutu, Bernhards
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Osorio, Lyda
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Penali, Louis K.
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Pereira, Dhelio ...
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Rahim, Awab G.
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Ramharter, Micha ...
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Sagara, Issaka
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Schramm, Birgit
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Seidlein, Lorenz
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Siqueira, Andre ...
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Sirima, Sodiomon ...
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Starzengruber, P ...
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Sutanto, Inge
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Taylor, Walter R ...
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Toure, Offianan ...
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Utzinger, Jurg
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Valea, Innocent
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Valentini, Giova ...
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White, Nicholas ...
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William, Timothy
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Woodrow, Charles ...
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Richmond, Caitli ...
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Guerin, Philippe ...
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Price, Ric N.
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Stepniewska, Kas ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
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Malaria Journal
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