Obesity as a clinical predictor for severe manifestation of dengue: a systematic review and meta-analysis

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Chen, Chao-YingKaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan. (författare)

Obesity as a clinical predictor for severe manifestation of dengue : a systematic review and meta-analysis

Artikel/kapitelEngelska2023

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BioMed Central (BMC),2023
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LIBRIS-ID:oai:DiVA.org:uu-509306
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-509306URI
https://doi.org/10.1186/s12879-023-08481-9DOI

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Språk:engelska
Sammanfattning på:engelska

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BackgroundSevere dengue often leads to poor clinical outcomes and high mortality; as a result, it is of vital importance to find prognostic factors associated with the severe form of dengue. Obesity is known to deteriorate many infectious diseases due to impaired immune responses. Several studies have suggested that obese patients with dengue infection tend to have more severe manifestations with poorer prognosis. However, a firm conclusion could not be drawn due to the varied results of these studies. Here, we aimed to conduct a systematic review and meta-analysis to investigate the association between obesity and dengue severity.MethodsA literature search for relevant studies was conducted in PubMed, Embase, Ovid Medline and Cochrane from inception to September 9, 2022. The two main keywords were “dengue” and “obesity”. Mantel-Haenszel method and random effects model was used to analyze the pooled odds ratio with 95% confidence intervals.ResultsA total of 15 article involving a total of 6,508 patients were included in the meta-analysis. Included patients in most studies were hospitalized pediatric patients. Only one study included adulthood data. Three cohort studies, four case-control studies, and one cross-sectional studies found a significant association between obesity and dengue severity. In contrast, three cohort studies, three case-control studies, and one cross-sectional study reported no significant relationship between obesity and dengue severity. Our analysis results showed that patient with obesity is 50% (OR = 1.50; 95%CI: 1.15–1.97) more likely to develop severe manifestation of dengue.ConclusionThis meta-analysis revealed that overweight could be a clinical predictor for severe disease for pediatric patients with dengue infection.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
Dengue
Obesity
Prognosis

Biuppslag (personer, institutioner, konferenser, titlar ...)

Chiu, Yu-YaoKaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Grad Inst Med, Coll Med, Ctr Trop Med & Infect Dis Res,Sch Med, Kaohsiung 807, Taiwan. (författare)
Chen, Yu-ChengKaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Grad Inst Med, Coll Med, Ctr Trop Med & Infect Dis Res,Sch Med, Kaohsiung 807, Taiwan. (författare)
Huang, Chung-HaoKaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Grad Inst Med, Coll Med, Ctr Trop Med & Infect Dis Res,Sch Med, Kaohsiung 807, Taiwan. (författare)
Wang, Wen-HungKaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Grad Inst Med, Coll Med, Ctr Trop Med & Infect Dis Res,Sch Med, Kaohsiung 807, Taiwan.;Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Coll Med, Sch Med, Kaohsiung 804, Taiwan. (författare)
Chen, Yen-HsuKaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Grad Inst Med, Coll Med, Ctr Trop Med & Infect Dis Res,Sch Med, Kaohsiung 807, Taiwan.;Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Coll Med, Sch Med, Kaohsiung 804, Taiwan.;Natl Yang Ming Chiao Tung Univ, Coll Biol Sci & Technol, Dept Biol Sci & Technol, Hsinchu 100, Taiwan. (författare)
Lin, Chun-YuUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Anestesiologi och intensivvård,Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan; Kaohsiung Med Univ, Grad Inst Med, Coll Med, Ctr Trop Med & Infect Dis Res, Sch Med, Kaohsiung 807, Taiwan(Swepub:uu)chuli862 (författare)
Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan.Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Infect Dis, Kaohsiung 807, Taiwan.;Kaohsiung Med Univ, Grad Inst Med, Coll Med, Ctr Trop Med & Infect Dis Res,Sch Med, Kaohsiung 807, Taiwan. (creator_code:org_t)

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Ingår i:BMC Infectious Diseases: BioMed Central (BMC)23:11471-2334

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Av författaren/redakt...: Chen, Chao-Ying; Chiu, Yu-Yao; Chen, Yu-Cheng; Huang, Chung-Hao; Wang, Wen-Hung; Chen, Yen-Hsu; visa fler...; Lin, Chun-Yu; visa färre...

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