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A Synthetic Cyclize...
A Synthetic Cyclized Antimicrobial Peptide with Potent Effects against Drug-Resistant Skin Pathogens
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- Kerr White, John (författare)
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden;Division of Clinical Microbiology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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- Mohanty, Soumitra (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden; Division of Clinical Microbiology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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- Muhammad, Taj (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Institute of Medical Sciences, University of Aberdeen, Ashgrove Road West, Foresterhill, Aberdeen AB25 2ZD, UK
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- de Arriba Sanchez de la Campa, Magdalena (författare)
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden;Division of Clinical Microbiology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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- Houssen, Wael E. (författare)
- Institute of Medical Sciences, University of Aberdeen, Ashgrove Road West, Foresterhill, Aberdeen AB25 2ZD, U.K.;Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, U.K.
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- Ferraz, Natalia, 1976- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Göransson, Ulf, 1970- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Brauner, Annelie (författare)
- Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, SE-171 77 Stockholm, Sweden;Division of Clinical Microbiology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
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(creator_code:org_t)
- American Chemical Society (ACS), 2023
- 2023
- Engelska.
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Ingår i: ACS - Infectious Diseases. - : American Chemical Society (ACS). - 2373-8227. ; 9:5, s. 1056-1063
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Dermal infections requiring treatment are usually treated with conventional antibiotics, but the rise of bacterial resistance to first-line antibiotics warrants alternative therapeutics. Here, we report that a backbone-cyclized antimicrobial peptide, CD4-PP, designed from the human host defense peptide LL-37, has strong direct antibacterial effects on antibiotic sensitive as well as resistant-type strains and clinical isolates of common skin pathogens in the low (<2) μM range. In addition, it influences innate immunity in keratinocytes, and treatment with CD4-PP is able to clear bacterial infections in infected keratinocytes. Additionally, CD4-PP treatment significantly reduces the wound area in a lawn of keratinocytes infected with MRSA. In conclusion, CD4-PP has the potential to serve as a future drug treating wounds infected with antibiotic-resistant bacteria.
Ämnesord
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- keratinocytes
- MRSA
- synthetic antimicrobial peptide
- LL-37
- bactericidal peptide
- wound closure
- Engineering Science with specialization in Nanotechnology and Functional Materials
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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