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Alterations of dopa...
Alterations of dopaminergic and serotonergic activity in the brain of sea-run Baltic salmon suffering a thiamine deficiency-related disorder
- Article/chapterEnglish2002
Publisher, publication year, extent ...
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Elsevier,2002
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-510155
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-510155URI
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https://doi.org/10.1111/j.1095-8649.2002.tb02435.xDOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Baltic salmon Salmo salar females displaying wiggling behaviour had significantly lower (P<0.05) hepatic and ovarian thiamine (vitamin B1) concentrations than the normal females, confirming that they suffered from a thiamine deficiency. A significantly (P<0.05) increased monoaminergic activity was found in the telencephalon and the hypothalamus of the wiggling individuals as indicated by [5-hydroxyindoleacetic acid (5-HIAA)]: [5-hydroxytryptamine (5-HT)] and [3,4-dihydroxyphenylacetic acid (DOPAC)]: [dopamine (DA)] ratios. The 5-HIAA concentrations of wiggling individuals were significantly (P<0.05) higher in the telencephalon and the hypothalamus compared to normal fish. Wiggling fish showed significantly (P<0.05) higher concentrations of the DA metabolite DOPAC in the hypothalamus and the brain stem compared to normal fish. Furthermore, the brain stem in wiggling fish contained significantly (P<0.05) less 5-HT than in normal individuals, which was also reflected in a significant (P<0.05) increase in the (5-HIAA): (5-HT) ratio. These results demonstrate an increased serotonergic and dopaminergic activity in wiggling compared to normal fish. The altered monoaminergic activity may be directly related to altered brain thiamine metabolism, but a general stress caused by thiamine deficiency and an inability to regulate swim bladder inflation may contribute. Furthermore, a changed brain monoaminergic activity may contribute to the behaviour characterizing wiggling fish.
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Elofsson, U. O. E.Department of Limnology, Evolutionary Biology Centre, Uppsala University
(author)
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Börjeson, H.
(author)
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Norrgren, L.
(author)
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Nilsson, G. E.
(author)
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Department of Limnology, Evolutionary Biology Centre, Uppsala University
(creator_code:org_t)
Related titles
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In:Journal of Fish Biology: Elsevier60:6, s. 1407-14160022-11121095-8649
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