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Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment

De Castelbajac, Thalia (författare)
French Agcy Food Environm & Occupat Hlth & Safety, Maisons Alfort, France.
Aiello, Kiara (författare)
German Fed Inst Risk Assessment, Berlin, Germany.
Arenas, Celia Garcia (författare)
German Fed Inst Risk Assessment, Berlin, Germany.
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Svingen, Terje (författare)
Tech Univ Denmark, Natl Food Inst, Lyngby, Denmark.
Ramhøj, Louise (författare)
Tech Univ Denmark, Natl Food Inst, Lyngby, Denmark.
Zalko, Daniel (författare)
Univ Toulouse, Toxalim Res Ctr Food Toxicol, INRAE, Toulouse, France.
Barouki, Robert (författare)
Univ Paris Cite, Inserm, Unit 1124, Paris, France.
Vanhaecke, Tamara (författare)
Vrije Univ Brussel VUB, Fac Med & Pharm, Dept Vitro Toxicol & Dermato Cosmetol IVTD, Brussels, Belgium.
Rogiers, Vera (författare)
Vrije Univ Brussel VUB, Fac Med & Pharm, Dept Vitro Toxicol & Dermato Cosmetol IVTD, Brussels, Belgium.
Audebert, Marc (författare)
Univ Toulouse, Toxalim Res Ctr Food Toxicol, INRAE, Toulouse, France.
Oelgeschlaeger, Michael (författare)
German Fed Inst Risk Assessment, Berlin, Germany.
Braeuning, Albert (författare)
German Fed Inst Risk Assessment, Berlin, Germany.
Blanc, Etienne (författare)
Univ Paris Cite, Inserm, Unit 1124, Paris, France.
Tal, Tamara (författare)
Helmholtz Ctr Environm Res, Leipzig, Germany.
Rüegg, Joëlle (författare)
Uppsala universitet,Fysiologi och miljötoxikologi
Fritsche, Ellen (författare)
Leibniz Res Inst Environm Med, Dusseldorf, Germany.
Marx-Stoelting, Philip (författare)
German Fed Inst Risk Assessment, Berlin, Germany.
Riviere, Gilles (författare)
French Agcy Food Environm & Occupat Hlth & Safety, Maisons Alfort, France.
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French Agcy Food Environm & Occupat Hlth & Safety, Maisons Alfort, France German Fed Inst Risk Assessment, Berlin, Germany. (creator_code:org_t)
Frontiers Media S.A. 2023
2023
Engelska.
Ingår i: Frontiers in Toxicology. - : Frontiers Media S.A.. - 2673-3080. ; 5
  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • New approach methodologies (NAMs) have the potential to become a major component of regulatory risk assessment, however, their actual implementation is challenging. The European Partnership for the Assessment of Risks from Chemicals (PARC) was designed to address many of the challenges that exist for the development and implementation of NAMs in modern chemical risk assessment. PARC's proximity to national and European regulatory agencies is envisioned to ensure that all the research and innovation projects that are initiated within PARC agree with actual regulatory needs. One of the main aims of PARC is to develop innovative methodologies that will directly aid chemical hazard identification, risk assessment, and regulation/policy. This will facilitate the development of NAMs for use in risk assessment, as well as the transition from an endpoint-based animal testing strategy to a more mechanistic-based NAMs testing strategy, as foreseen by the Tox21 and the EU Chemical's Strategy for Sustainability. This work falls under work package 5 (WP5) of the PARC initiative. There are three different tasks within WP5, and this paper is a general overview of the five main projects in the Task 5.2 'Innovative Tools and methods for Toxicity Testing,' with a focus on Human Health. This task will bridge essential regulatory data gaps pertaining to the assessment of toxicological prioritized endpoints such as non-genotoxic carcinogenicity, immunotoxicity, endocrine disruption (mainly thyroid), metabolic disruption, and (developmental and adult) neurotoxicity, thereby leveraging OECD's and PARC's AOP frameworks. This is intended to provide regulatory risk assessors and industry stakeholders with relevant, affordable and reliable assessment tools that will ultimately contribute to the application of next-generation risk assessment (NGRA) in Europe and worldwide.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Nyckelord

PARC
NGRA
NAMs
hazard assessment
human health

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