id:"swepub:oai:DiVA.org:uu-51073"
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- Franck, JohanKarolinska Institutet (author)
Met-enkephalin inhibits 5-hydroxytryptamine release from the rat ventral spinal cord via delta opioid receptors
- Article/chapterEnglish1996
Publisher, publication year, extent ...
- Elsevier BV,1996
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-51073
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-51073URI
- https://doi.org/10.1016/0028-3908(96)84646-6DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:1928854URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- The effect of opioid receptor agonists and antagonists on the electrically evoked release of endogenous serotonin (5-hydroxytryptamine, 5-HT) was studied in superfused slices of the rat ventral lumbar spinal cord. Met-ENK (1 x 10(-8)M-1 x 10(-6)M) and DPDPE (1 x 10(-8)M-1 x 10(-6)M) reduced the evoked 5-Ht release in a concentration dependent fashion. DAMGO (1 x 10(-8)-1 x 10(-6)) and (-)-trans-(1S,2S)-U-50488 (1 x 10(-6)M) had no effect on the 5-HT release. The inhibitory effect of met-ENK was completely abolished by ICI-174,864, but neither by naloxonazine nor nor-binaltorphimine. Following i.c.v. treatment with 5,7-dihydroxytryptamine (5,7-DHT), the tissue concentration of 5-HT was reduced by 97%, whereas the concentration of noradrenaline was reduced by only 5%. The tissue concentration of met-ENK, as measured by radioimmunoassay, was not significantly altered. The results suggest that met-ENK is present in the rat ventral spinal cord mainly in non-serotonergic nerve terminals and exerts an inhibitory action on 5-HT release via delta opioid receptors.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
- DAMGO
- DPDPE
- 5
- 7-dihydroxytryptamine
- 5-hydroxytryptamine
- ICI-174
- 864
- met-enkephalin
- naloxonazine
- nor-binaltorphimine
- opioid receptors
- spinal cord slices (ventral)
- (-)-trans-(1S
- 2S)-U-50488
- PHARMACY
- FARMACI
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Nylander, IngridDepartment of Clinical Neuroscience, Alcohol and Drug Dependence Research Section, Karolinska Hospital,Pharmacology(Swepub:uu)iny08577 (author)
- Rosen, AnnikaKarolinska Institutet (author)
- Karolinska InstitutetDepartment of Clinical Neuroscience, Alcohol and Drug Dependence Research Section, Karolinska Hospital (creator_code:org_t)
Related titles
- In:Neuropharmacology: Elsevier BV35:6, s. 743-7490028-39081873-7064
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